Magnetic nanoparticles coated with dimercaptosuccinic acid: development, characterization, and application in biomedicine

Ruiz, Amalia; Morais, P.C.; Azevedo, Ricardo Bentes; Lacava, Z.G.M.; Villanueva, Ángeles; Morales, M.P.

doi:10.1007/s11051-014-2589-6

Cited by 43 publications

(34 citation statements)

References 81 publications

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“…Coating of NPs is a strategy to prevent or reduce toxicity and undesired toxic side effects . Nevertheless, biofunctionalization of magnetic NPs is not only directed to improve the biocompatibility with cells, but also to modify the cell interaction processes, pharmacokinetics, and biodistribution of the NPs . For instance, the residence time of circulating iron oxide NPs can be doubled by simple functionalization with “stealth” polymer, polyethylene glycol (PEG), while at the same time, the particle accumulation in different organs can be reduced .…”

Section: Magnetic Npsmentioning

confidence: 99%

Advances in Magnetic Nanoparticles for Biomedical Applications

Cardoso

Francesko

Ribeiro

et al. 2017

Adv Healthcare Materials

550

330

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Magnetic nanoparticles (NPs) are emerging as an important class of biomedical functional nanomaterials in areas such as hyperthermia, drug release, tissue engineering, theranostic, and lab-on-a-chip, due to their exclusive chemical and physical properties. Although some works can be found reviewing the main application of magnetic NPs in the area of biomedical engineering, recent and intense progress on magnetic nanoparticle research, from synthesis to surface functionalization strategies, demands for a work that includes, summarizes, and debates current directions and ongoing advancements in this research field. Thus, the present work addresses the structure, synthesis, properties, and the incorporation of magnetic NPs in nanocomposites, highlighting the most relevant effects of the synthesis on the magnetic and structural properties of the magnetic NPs and how these effects limit their utilization in the biomedical area. Furthermore, this review next focuses on the application of magnetic NPs on the biomedical field. Finally, a discussion of the main challenges and an outlook of the future developments in the use of magnetic NPs for advanced biomedical applications are critically provided.

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Section: Magnetic Npsmentioning

confidence: 99%

Advances in Magnetic Nanoparticles for Biomedical Applications

Cardoso

Francesko

Ribeiro

et al. 2017

Adv Healthcare Materials

550

330

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show abstract

“…co-precipitation or thermal composition. 26 , 27 , 29 When exploited for industrial applications the multi-layered SPION has to comply with easy, clean and cost effective synthetic processes, and therefore in many cases ruling out methods in non-aqueous media. 30 Following the multilayer concept development process for biomedical application the most advantageous characteristic of iron oxide nanoparticles is the possibility to visualize them in the body using magnetic resonance imaging (MRI).…”

Section: Multilayer Conceptmentioning

confidence: 99%

Magnetic Nanoparticles in Cancer Theranostics

Gobbo¹,

Sjaastad²,

Radomski³

et al. 2015

Theranostics

416

237

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In a report from 2008, The International Agency for Research on Cancer predicted a tripled cancer incidence from 1975, projecting a possible 13-17 million cancer deaths worldwide by 2030. While new treatments are evolving and reaching approval for different cancer types, the main prevention of cancer mortality is through early diagnosis, detection and treatment of malignant cell growth. The last decades have seen a development of new imaging techniques now in widespread clinical use. The development of nano-imaging through fluorescent imaging and magnetic resonance imaging (MRI) has the potential to detect and diagnose cancer at an earlier stage than with current imaging methods. The characteristic properties of nanoparticles result in their theranostic potential allowing for simultaneous detection of and treatment of the disease. This review provides state of the art of the nanotechnological applications for cancer therapy. Furthermore, it advances a novel concept of personalized nanomedical theranostic therapy using iron oxide magnetic nanoparticles in conjunction with MRI imaging. Regulatory and industrial perspectives are also included to outline future perspectives in nanotechnological cancer research.

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“…14 Besides providing SPION stability in physiological conditions, DMSA offers the further benet of two functional groups (COOH and SH), which both can be exploited for the covalent bonding of a variety of organic molecules. 15 To perform the ligand exchange we used a literature methodology 16 (see Scheme 1), modied by the use of sonication during the reaction, which allowed a signicant shortening of the exchange time (40 min vs. 12-24 h of the literature procedures), while maintaining the quasi-quantitative recovery of the water-dispersed SPION.…”

Section: Synthesis Of the Iron Oxide Nanoparticlesmentioning

confidence: 99%