Magnetic Polyamide Nanocomposites for the Microextraction of Benzophenones from Water Samples

Ghambari, Hoda; Reyes-Gallardo, Emilia M.; Lucena, Rafael; Saraji, Mohammad; Cárdenas, Soledad

doi:10.3390/molecules24050953

Cited by 6 publications

(4 citation statements)

References 32 publications

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“…Possible surface modification opens the doorway for various applications and smart construction production [19,58]. Nylon 6 is a frequently used polyamide for nanocomposite synthesis [58][59][60][61][62][63][64]. Due to high biocompatibility, stability, and toughness, nylon 6 is used for medical plastic material production and nanoparticle coating [58,[65][66][67].…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin-Loaded Silica Nanocomposites for Cancer Treatment

et al. 2023

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Silica nanoparticles (SiNPs) are a promising material for nanomedicine technology. SiNPs are considered a powerful tool for drug delivery, functional coatings and films, and biomolecule separation due to their stability, biocompatibility, and accessible surface modification. Herein, the synthesis of SiNPs and SiNPs nylon 6 (SiNPs-Nylon) coated nanocomposites was proposed. Transmission electron microscopy (TEM) and dynamic light scattering (DLS) were used for morphology, size, and stability analysis. Anticancer drug doxorubicin (DOX) loading to the nanocomposites and pH-dependent release experiments are presented. DOX-loaded nanocomposites with high drug capacities of up to 258 μg/mg (DOX/SiNPs) and 493 μg/mg (DOX/SiNPs-Nylon) show effective inhibition of A549 and HEK 293FT cell lines. The IC50 values were 0.08 ± 0.01 µM in terms of DOX amount and recalculated as 0.31 ± 0.04 µg/mL in terms of the concentration of SiNPs for the HEK 293FT cells. Therefore, silica nanocomposites have a high potential for cancer treatment.

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Section: Introductionmentioning

confidence: 99%

Doxorubicin-Loaded Silica Nanocomposites for Cancer Treatment

et al. 2023

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“…Magnetic nanoparticles (MNPs) have broad application prospects in various molecule loading and separation applications due to their unique properties [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. MNPs represent a significant doorway for biomolecules such as proteins, nucleic acids (NA), and metabolites separation and detection [2,[14][15][16][17][18][20][21][22][23][24][25][26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

“…However, for specific NA capture, the surface coating is required [17,18,28,33]. Nylon 6 (Ny6) is a frequently used polyamide polymer for various composites synthesis [13,[42][43][44][45][46]. Ny6 is a high-toughness, chemically stable, low-density, easily prepared by typical materials, and biocompatible polymer [47].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Nylon 6 Nanocomposites for the Microextraction of Nucleic Acids from Biological Samples

2022

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Magnetic Fe3O4 nanoparticles (MNPs) have great potential for nucleic acid separation, detection, and delivery. MNPs are considered a valuable tool in biomedicine due to their cost-effectiveness, stability, easy surface functionalization, and the possibility of the manipulations under a magnetic field. Herein, the synthesis of magnetic nylon 6 nanocomposites (MNPs@Ny6) was investigated. Transmission electron microscopy (TEM) was used for morphology and size analysis. A new method of UV-induced immobilization of oligonucleotides on MNPs@Ny6 for nucleic acid magnetic separation was proposed. MNPs@Ny6 shows a high oligonucleotide binding capacity of 2.2 nmol/mg with 73.3% loading efficiency. The proposed system has been applied to analyze model mixtures of target RNA on the total yeast RNA background. The RNA target isolation efficiency was 60% with high specificity. The bind RNA release was 88.8% in a quantity of 0.16 nmol/mg. The total RNA capture efficiency was 53%. Considering this, the MNPs@Ny6 is an attractive candidate for nucleic acids-specific magnetic isolation.

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“…Therefore, polyamide polymer can be used as an extraction medium in sample preparation. Until now, polyamide polymers have been used to fabricate sorptive phase in several formats including electrospun fibers [8][9][10], paperbased sorptive phases [11], and magnetic nanocomposites [12]. However, these reported formats always required complicated synthesis procedures, which was difficult to achieve in a general laboratory.…”

Section: Introductionmentioning

confidence: 99%

Application of a novel nylon needle filter‐based solid‐phase extraction device to determination of 1‐hydroxypyrene in urine

Yue

Zhou

Peng

et al. 2022

J of Separation Science

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In this work, a simple and miniaturized solid‐phase extraction device was constructed by connecting a commercial nylon needle filter to a syringe, which was applied for extracting 1‐hydroxypyrene from a urine sample via hydrophobic and hydrogen bond interactions. The nylon membrane in the needle filter acted as the solid‐phase extraction adsorbent, meanwhile, it filtered the particles in the urine sample. To obtain high extraction efficiency, key parameters influencing extraction recovery were investigated. The entire pretreatment process was accomplished within 5 min under the optimal conditions. By coupling high‐performance liquid chromatography–ultraviolet, a rapid, low‐cost, and convenient nylon needle filter‐based method was established for the analysis of 1‐hydroxypyrene in a complex urine matrix. Within the linearity range of 0.2–1000 μg/L, the method exhibited a satisfactory correlation coefficient (R = 0.9999). The limit of detection was 0.06 μg/L, and the recoveries from urine sample spiked with three concentrations (5, 20, and 100 μg/L) ranged from 105.8% to 113.1% with the relative standard deviations less than 6.7% (intra‐day, n = 6) and 8.9% (inter‐day, n = 4). Finally, the proposed method was successfully applied for detecting 1‐hydroxypyrene in urine samples from college students, smokers, gas station workers, and chip factory workers. The detected concentration in actual urine samples ranged from 0.46 to 5.26 μg/L. Taken together, this simple and cost‐effective nylon needle filter‐based solid‐phase extraction device showed an excellent application potential for pretreating hydrophobic analytes from aqueous samples.

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Magnetic Polyamide Nanocomposites for the Microextraction of Benzophenones from Water Samples

Cited by 6 publications

References 32 publications

Doxorubicin-Loaded Silica Nanocomposites for Cancer Treatment

Doxorubicin-Loaded Silica Nanocomposites for Cancer Treatment

Magnetic Nylon 6 Nanocomposites for the Microextraction of Nucleic Acids from Biological Samples

Application of a novel nylon needle filter‐based solid‐phase extraction device to determination of 1‐hydroxypyrene in urine

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