Magnetic Resonance-Guided Laser Interstitial Thermal Therapy for Brain Tumors

Canney, Michael; Carpentier, Alexandre

doi:10.1007/978-94-007-2019-0_20

Cited by 2 publications

(3 citation statements)

References 25 publications

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“…This treatment profile is more representative of the symmetric kill zones observed after laser photothermal heating of tissue [67, 68] as compared to the asymmetric temperature and kill zones typically observed using cell monolayers culture models [19]. The treatment zone also corresponds with the shape of light propagation predicted by Monte Carlo simulations [9, 69].…”

Section: Discussionmentioning

confidence: 84%

3D viability imaging of tumor phantoms treated with single-walled carbon nanohorns and photothermal therapy

Whitney¹,

DeWitt²,

Whited³

et al. 2013

Nanotechnology

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Objective A new image analysis method called the Spatial Phantom Evaluation of Cellular Thermal Response in Layers (SPECTRL) is presented for assessing spatial viability response to nanoparticle enhanced photothermal therapy in tissue representative phantoms. Materials and Methods Sodium alginate phantoms seeded with MDA-MB-231 breast cancer cells and single walled nanohorns were laser irradiated with an ytterbium fiber laser at a wavelength of 1064 nm and irradiance of 3.8 watts/cm2 for 10–80 seconds. SPECTRL quantitatively assessed and correlated 3D viability with spatiotemporal temperature. Results and Conclusions Based on this analysis, kill and transition zones increased from 3.7 mm3 and 13 mm3 respectively to 44.5 mm3 and 44.3 mm3 as duration was increased from 10–80 seconds. SPECTRL provides a quantitative tool for measuring precise spatial treatment regions, providing information necessary to tailor therapy protocols.

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Section: Discussionmentioning

confidence: 84%

3D viability imaging of tumor phantoms treated with single-walled carbon nanohorns and photothermal therapy

Whitney¹,

DeWitt²,

Whited³

et al. 2013

Nanotechnology

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“…1 Neuroablative procedures targeting different pain centers have been investigated by neurosurgeons to alleviate the suffering of patients with intractable cancer pain. One such recently investigated procedure is MRI-guided laser interstitial thermal therapy (LITT) 2 that targets the cingulum (pain center in the brain), and may offer measurable advantages for cancer pain management over existing ad-hoc treatment options, such as radio-frequency ablation 3 which only provides temporary pain relief. One of the major advantages enjoyed by LITT is its compatibility with MRI, allowing for high resolution in vivo imaging to be used in LITT procedures.…”

Section: Introductionmentioning

confidence: 99%

“…Further, multi-parametric MRI (MP-MRI) offers the ability to precisely ablate the cingulum via MRI guidance to avoid damage to critical neighboring structures. 2 Although LITT is highly promising for pain management, very little is known about specific early treatment changes caused due to thermal ablation or indeed the accuracy of this procedure in targeting the cingulum and the impact to surrounding tissues. 4 …”

Section: Introductionmentioning

confidence: 99%

Identifying MRI markers to evaluate early treatment-related changes post-laser ablation for cancer pain management

Tiwari

Danish²,

Madabhushi

2014

SPIE Proceedings

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Laser interstitial thermal therapy (LITT) has recently emerged as a new treatment modality for cancer pain management that targets the cingulum (pain center in the brain), and has shown promise over radio-frequency (RF) based ablation which is reported to provide temporary relief. One of the major advantages enjoyed by LITT is its compatibility with magnetic resonance imaging (MRI), allowing for high resolution in vivo imaging to be used in LITT procedures. Since laser ablation for pain management is currently exploratory and is only performed at a few centers worldwide, its short-, and long-term effects on the cingulum are currently unknown. Traditionally treatment effects are evaluated by monitoring changes in volume of the ablation zone post-treatment. However, this is sub-optimal since it involves evaluating a single global parameter (volume) to detect changes pre-, and post-MRI. Additionally, the qualitative observations of LITT-related changes on multi-parametric MRI (MP-MRI) do not specifically address differentiation between the appearance of treatment related changes (edema, necrosis) from recurrence of the disease (pain recurrence). In this work, we explore the utility of computer extracted texture descriptors on MP-MRI to capture early treatment related changes on a per-voxel basis by extracting quantitative relationships that may allow for an in-depth understanding of tissue response to LITT on MRI, subtle changes that may not be appreciable on original MR intensities. The second objective of this work is to investigate the efficacy of different MRI protocols in accurately capturing treatment related changes within and outside the ablation zone post-LITT. A retrospective cohort of studies comprising pre- and 24-hour post-LITT 3 Tesla T1-weighted (T1w), T2w, T2-GRE, and T2-FLAIR acquisitions was considered. Our scheme involved (1) inter-protocol as well as inter-acquisition affine registration of pre- and post-LITT MRI, (2) quantitation of MRI parameters by correcting for intensity drift in order to examine tissue-specific response, and (3) quantification of MRI maps via texture and intensity features to evaluate changes in MR markers pre- and post-LITT. A total of 78 texture features comprising of non-steerable and steerable gradient and second order statistical features were extracted from pre- and post-LITT MP-MRI on a per-voxel basis. Quantitative, voxel-wise comparison of the changes in MRI texture features between pre-, and post-LITT MRI indicate that (a) steerable and non-steerable gradient texture features were highly sensitive as well as specific in predicting subtle micro-architectural changes within and around the ablation zone pre- and post-LITT, (b) FLAIR was identified as the most sensitive MRI protocol in identifying early treatment changes yielding a normalized percentage change of 360% within the ablation zone relative to its pre-LITT value, and (c) GRE was identified as the most sensitive MRI protocol in quantifying changes outside the ablation zone post-LITT. Our preliminary results...

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Magnetic Resonance-Guided Laser Interstitial Thermal Therapy for Brain Tumors

Cited by 2 publications

References 25 publications

3D viability imaging of tumor phantoms treated with single-walled carbon nanohorns and photothermal therapy

3D viability imaging of tumor phantoms treated with single-walled carbon nanohorns and photothermal therapy

Identifying MRI markers to evaluate early treatment-related changes post-laser ablation for cancer pain management

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