Magnetic Resonance Image-Guided Radiotherapy (MRIgRT): A 4.5-Year Clinical Experience

Henke, Lauren E.; Contreras, J.; Green, O.L.; Cai, Bin; Kim, H.; Roach, Michael C.; Olsen, Jeffrey R.; Fischer‐Valuck, Benjamin W.; Mullen, D.; Kashani, Rojano; Thomas, Maria; Huang, Jiayi; Zoberi, Imran; Yang, Deshan; Rodriguez, Vivian; Bradley, J.D.; Robinson, Clifford G.; Parikh, Parag J.; Mutic, Sasa; Michalski, Jeff M.

doi:10.1016/j.clon.2018.08.010

Cited by 114 publications

(117 citation statements)

References 31 publications

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“…According to a previous publication by Washington University, they reported 94 patients with SBRT (30%), 76 patients (24%) with 3D conformal RT, and 146 patients (46%) with IMRT in 316 patient series [8]. Two years later they reported their updated results with 666 courses of MRIgRT including 266 SBRT (39.9%), 240 IMRT (36%) and 160 3D conformal RT plans [9]. In our institution, we mostly use MR-linac for radiosurgery purposes.…”

Section: Discussionmentioning

confidence: 99%

First 500 Fractions Delivered with a Magnetic Resonance-guided Radiotherapy System: Initial Experience

Sahin¹,

Mustafayev²,

Güngör³

et al. 2019

Cureus

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Improved soft-tissue visualization, afforded by magnetic resonance imaging integrated into a radiation therapy linear accelerator-based radiation delivery system (MR-linac) promises improved image-guidance. The availability of MR-imaging can facilitate on-table adaptive radiation planning and enable real-time intra-fraction imaging with beam gating without additional exposure to radiation. However, the novel use of magnetic resonance-guided radiation therapy (MRgRT) in the field of radiation oncology also potentially poses challenges for routine clinical implementation. Herein the early experience of a single institution, implementing the first MRgRT system in the country is reported. We aim to describe the workflow and to characterize the clinical utility and feasibility of routine use of an MR-linac system.

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Section: Discussionmentioning

confidence: 99%

First 500 Fractions Delivered with a Magnetic Resonance-guided Radiotherapy System: Initial Experience

Sahin¹,

Mustafayev²,

Güngör³

et al. 2019

Cureus

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“…Cine-MRI during treatment enables advanced motion management based on real-time soft tissue anatomic feedback such as treatment beam gating [11,16,17]. This eliminates the need for invasive implantation of fiducial markers as well as the application of internal target volumes (ITV) in order to account for intrafractional motion, and thereby offers the potential for margin reduction and hence a lower risk of ensuing toxicity [18].…”

Section: Introductionmentioning

confidence: 99%

First prospective clinical evaluation of feasibility and patient acceptance of magnetic resonance-guided radiotherapy in Germany

et al. 2020

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Purpose Magnetic resonance-guided radiotherapy (MRgRT) has recently been introduced in our institution. As MRgRT requires high patient compliance compared to conventional techniques and can be associated with prolonged treatment times, feasibility and patient tolerance were prospectively assessed using patient-reported outcome questionnaires (PRO-Q). Materials and methods Forty-three patients were enrolled in a prospective observational study and treated with MRgRT on a low-field hybrid Magnetic Resonance Linear Accelerator system (MR-Linac) between April 2018 and April 2019. For assistance in gated breath-hold delivery using cine-MRI, a video feedback system was installed. PRO-Qs consisted of questions on MR-related complaints and also assessed aspects of active patient participation. Results The most commonly treated anatomic sites were nodal metastases and liver lesions. The mean treatment time was 34 min with a mean beam-on time of 2:17 min. Gated stereotactic body radiotherapy (SBRT) was applied in 47% of all patients. Overall, patients scored MRgRT as positive or at least tolerable in the PRO-Q. Almost two thirds of patients (65%) complained about at least one item of the PRO-Q (score ≥4), mainly concerning coldness, paresthesia, and uncomfortable positioning. All patients reported high levels of satisfaction with their active role using the video feedback system in breath-hold delivery. Conclusion MRgRT was successfully implemented in our clinic and well tolerated by all patients, despite MR-related complaints and complaints about uncomfortable immobilization. Prospective clinical studies are in development for further evaluation of MRgRT and for quantification of the benefit of MR-guided on-table adaptive radiotherapy.

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“…The commercial availability of combined magnetic resonance imaging (MRI) and radiotherapy units has fuelled pursuit of the clinical applications of magnetic resonance image guided radiotherapy (MRgRT) [1][2][3][4][5][6]. MRI provides superior soft tissue contrast compared to standard onboard X-ray based imaging without the additional ionising radiation risk [7].…”

Section: Introductionmentioning

confidence: 99%

Feasibility of magnetic resonance guided radiotherapy for the treatment of bladder cancer

Hunt

Hanson

Dunlop

et al. 2020

Clinical and Translational Radiation Oncology

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Magnetic Resonance Image-Guided Radiotherapy (MRIgRT): A 4.5-Year Clinical Experience

Cited by 114 publications

References 31 publications

First 500 Fractions Delivered with a Magnetic Resonance-guided Radiotherapy System: Initial Experience

First 500 Fractions Delivered with a Magnetic Resonance-guided Radiotherapy System: Initial Experience

First prospective clinical evaluation of feasibility and patient acceptance of magnetic resonance-guided radiotherapy in Germany

Feasibility of magnetic resonance guided radiotherapy for the treatment of bladder cancer

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