Magnetic Resonance Imaging–Guided versus Surrogate-Based Motion Tracking in Liver Radiation Therapy: A Prospective Comparative Study

Paganelli, Chiara; Seregni, Matteo; Fattori, Giovanni; Summers, Paul; Bellomi, Massimo; Baroni, Guido; Riboldi, Marco

doi:10.1016/j.ijrobp.2014.12.013

Cited by 44 publications

(51 citation statements)

References 44 publications

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“…Cine MRI images may be useful when treating without respiratory management particularly in patients with unreliable 4D CT imaging . Among other factors, the absence of ionizing radiation using MRI has facilitated the application of cine MRI for the development of motion models in several different treatment sites including the abdomen, thorax, liver, breast, and rectum among other sites. The emergence of online MRI‐guided radiation delivery has also permitted the increased utilization of cine MRI techniques for real‐time motion assessment and the construction of motion models …”

Section: Motion In Radiation Therapymentioning

confidence: 99%

Motion management strategies and technical issues associated with stereotactic body radiotherapy of thoracic and upper abdominal tumors: A review from NRG oncology

et al. 2017

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The efficacy of stereotactic body radiotherapy (SBRT) has been well demonstrated. However, it presents unique challenges for accurate planning and delivery especially in the lungs and upper abdomen where respiratory motion can be significantly confounding accurate targeting and avoidance of normal tissues. In this paper we review the current literature on SBRT for lung and upper abdominal tumors with particular emphasis on addressing respiratory motion and its affects. We provide recommendations on strategies to manage motion for different, patient specific situations. Some of the recommendations will potentially be adopted to guide clinical trial protocols.

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Section: Motion In Radiation Therapymentioning

confidence: 99%

Motion management strategies and technical issues associated with stereotactic body radiotherapy of thoracic and upper abdominal tumors: A review from NRG oncology

et al. 2017

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“…Paganelli et al. compared magnetic resonance imaging‐guided versus surrogate‐based motion tracking in liver radiation therapy . In Fig.…”

Section: Motion Monitoring Image Guided Particle Therapymentioning

confidence: 99%

Motion management in particle therapy

Mori¹,

Knopf

Umegaki

2018

Medical Physics

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In this review article, we introduced the importance of “motion management” in advanced particle therapy. Several publications have reported that organ motion causes dose distribution disturbances due to interplay and blurring effects. Furthermore, motion can result in target dose miss and unwanted dose to healthy structures around the target. To avoid these problems, motion should be assessed and monitored prior and during treatment. In this review article, we give an overview about clinically available motion monitoring systems. Based on the acquired motion information an adequate motion mitigation technique should be chosen. This article reviews the clinical status of motion mitigation techniques like rescanning, gating and tracking. A limited number of centers have now started the treatment of targets in the thorax and abdomen using scanned particle beams. Therefore, the establishment of guidelines for motion monitoring and motion mitigation will be essential in the coming years.

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“…Common motion management strategies currently used in radiotherapy include respiration gating, real-time tumor tracking, and breath-hold techniques where external or internal surrogates are typically used to derive the patient and tumor position [1-4]. While these methods may yield an improved treatment with reduced margins, they have inherent limitations.…”

Section: Introductionmentioning

confidence: 99%

“…There have been studies to track tumor motion with 2D cine MR images [4, 9, 10]. However, only a few groups have analyzed the correlation between the tumor motion and surrogate using 2D dynamic MR imaging techniques [4, 10], and none of them directly imaged the tumor and the external surrogate simultaneously.…”

Section: Introductionmentioning

confidence: 99%

“…However, only a few groups have analyzed the correlation between the tumor motion and surrogate using 2D dynamic MR imaging techniques [4, 10], and none of them directly imaged the tumor and the external surrogate simultaneously. In this study, we propose a method to simultaneously track the 3D position of the tumor and external surrogates with dynamic MRI, which allows us to evaluate the correlation between the tumor motion and external surrogate signal for radiation therapy.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of lung tumor motion management in radiation therapy with dynamic MRI

Park

Farah

Shea³

et al. 2017

SPIE Proceedings

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Surrogate-based tumor motion estimation and tracing methods are commonly used in radiotherapy despite the lack of continuous real time 3D tumor and surrogate data. In this study, we propose a method to simultaneously track the tumor and external surrogates with dynamic MRI, which allows us to evaluate their reproducible correlation. Four MRI-compatible fiducials are placed on the patient's chest and upper abdomen, and multi-slice 2D cine MRIs are acquired to capture the lung and whole tumor, followed by two-slice 2D cine MRIs to simultaneously track the tumor and fiducials, all in sagittal orientation. A phase-binned 4D-MRI is first reconstructed from multi-slice MR images using body area as a respiratory surrogate and group-wise registration. The 4D-MRI provides 3D template volumes for different breathing phases. 3D tumor position is calculated by 3D-2D template matching in which 3D tumor templates in 4D-MRI reconstruction and the 2D cine MRIs from the two-slice tracking dataset are registered. 3D trajectories of the external surrogates are derived via matching a 3D geometrical model to the fiducial segmentations on the 2D cine MRIs. We tested our method on five lung cancer patients. Internal target volume from 4D-CT showed average sensitivity of 86.5% compared to the actual tumor motion for 5 min. 3D tumor motion correlated with the external surrogate signal, but showed a noticeable phase mismatch. The 3D tumor trajectory showed significant cycle-to-cycle variation, while the external surrogate was not sensitive enough to capture such variations. Additionally, there was significant phase mismatch between surrogate signals obtained from fiducials at different locations.

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Magnetic Resonance Imaging–Guided versus Surrogate-Based Motion Tracking in Liver Radiation Therapy: A Prospective Comparative Study

Cited by 44 publications

References 44 publications

Motion management strategies and technical issues associated with stereotactic body radiotherapy of thoracic and upper abdominal tumors: A review from NRG oncology

Motion management strategies and technical issues associated with stereotactic body radiotherapy of thoracic and upper abdominal tumors: A review from NRG oncology

Motion management in particle therapy

Evaluation of lung tumor motion management in radiation therapy with dynamic MRI

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