Magnetic Seizure Therapy of Major Depression

Lisanby, Sarah H.; Schläepfer, Thomas E.; Fisch, Hans-Ulrich; Sackeïm, Harold A.

doi:10.1001/archpsyc.58.3.303

Cited by 205 publications

(103 citation statements)

References 18 publications

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“…Therefore targeting seizures to focal cortical areas, such as regions of the prefrontal cortex, may reduce some of the side effects of convulsive treatment. Magnetic seizure therapy (MST) has now been tested in proof of concept studies both in nonhuman primates and patients (Lisanby et al, 2001b) and preliminary results on cognitive side effects of the treatment compared to those of ECT have been obtained (Lisanby et al, 2001a). Much additional research is obviously needed to evaluate the putative clinical efficacy of this approach and to determine if it has significant advantages over ECT.…”

Section: Effects On Major Depressionmentioning

confidence: 99%

Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Affective Disorders

Schläepfer

Kosel²,

Nemeroff

2002

Neuropsychopharmacol

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Transcranial magnetic stimulation (TMS) is a relatively noninvasive technique to interfere with the function of small cortical areas through currents induced by alternating magnetic fields emanating from a handheld coil placed directly above the targeted area. This technique has clear effects on a whole range of measures of brain function and has become an important research tool in neuropsychiatry. More recently, TMS has been studied in psychiatry mainly to assess its putative therapeutic effects in treatment refractory major depression. Most studies indicate that both low-frequency TMS and higher (20 Hz) frequency repetitive TMS may have some antidepressant properties. However, definite therapeutic effects of clinical significance still remain to be demonstrated.

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Section: Effects On Major Depressionmentioning

confidence: 99%

Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Affective Disorders

Schläepfer

Kosel²,

Nemeroff

2002

Neuropsychopharmacol

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“…In 2001 ' magnetic seizure therapy ' was used for the fi rst time on a human subject in a course of four sessions which were well tolerated and led to improvement on the Hamilton Rating Scale for Depression, without any change to cognition (Lisanby et al, 2001b). A randomized study by Lisanby et al investigated the safety and effi cacy of MST compared to ECT in 10 patients (Lisanby et al, 2003a) using a pulse frequency of 40 -60 Hz, with train duration of 0.5 -8.0 s at maximal stimulator output (400 pulses).…”

Section: What Progress Has Been Made Towards Clinical Use Of Mst?mentioning

confidence: 99%

“…Though studies in humans are based on individual case reports or small (less than 20 participants) groups there is growing evidence that MST is associated with few subjective and objective cognitive side effects (Hoy & Fitzgerald, 2010b;Kayser et al, 2011;Kosel et al, 2003;Lisanby et al, 2003a;Lisanby et al, 2001b), as well as rapid recovery of orientation after treatment compared with ECT (Kirov et al, 2008;White et al, 2006). Though more studies are needed, the neuropsychological profi le is likely to be superior to ECT.…”

Section: What Are the Effects On Cognition?mentioning

confidence: 99%

The Use of ECT and MST in treating depression

Allan

Ebmeier

2011

International Review of Psychiatry

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Electroconvulsive therapy (ECT) has been used clinically since 1938. Its most common use is in the treatment of depression: fi rst line treatment where rapid recovery is a priority, but more frequently as an effective treatment for patients who do not respond to pharmacological and psychological approaches. Whilst it is widely hailed as an effective treatment, concerns about its effect on cognition remain. The development of magnetic seizure therapy (MST) over the past decade has attempted to devise a therapy with comparable effi cacy to ECT, but without the associated cognitive side effects. The rationale for this is that MST uses magnetic fi elds to induce seizures in the cortex, without electrical stimulation of brain structures involved with memory. MST has been used successfully in the treatment of depression, yet there is a dearth of literature in comparison with ECT. We present a systematic review of the literature on ECT (from 2009ECT (from -2011 and MST (from 2001MST (from -2011.

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“…The first patient to receive MST was a 20 year-old female, with a history of a 3-year episode of depression, refractory to multiple antidepressant trials. 59 MST was administered three times per week, under the same general anesthetic regimen as used for ECT. MST generated generalized tonic-clonic seizures, and after the fourth treatment the patient presented with a 35% reduction on the HRSD score, with no reduction in the patient's mini mental examination.…”

Section: Magnetic Seizure Therapymentioning

confidence: 99%

Terapias somáticas para transtornos psiquiátricos resistentes ao tratamento

Braga

Petrides²

2007

Rev. Bras. Psiquiatr.

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A b s t r a c t Objective: This paper reviews the current knowledge of somatic treatment in psychiatry, with a focus on treatment-resistant psychiatric disorders. Method: A computerized search of the literature was conducted on Medline using the words "electroconvulsive therapy", "transcranial magnetic stimulation", "vagus nerve stimulation", "deep brain stimulation", and "magnetic seizure therapy". References from each paper were also screened. Results: The development of new non-pharmacological psychiatric interventions in the past decades has renewed the clinical and research interest in somatic therapies. Although electroconvulsive therapy remains the only somatic treatment with undisputed efficacy; transcranial magnetic stimulation, vagus nerve stimulation and deep brain stimulation all offer potential as novel means of psychiatric treatment. Conclusions: New treatment modalities still have an insufficient body of data. Notwithstanding, biological strategies continue to hold promise as a safer and more effective approach to psychiatric treatment. Descriptors: Brain diseases; Electroconvulsive therapy; Transcranial magnetic stimulation; Vagus nerve; Deep brain stimulationResumo Objetivo: O presente artigo é uma revisão do conhecimento atual relativo às terapias somáticas em psiquiatria, com foco em transtornos psiquiátricos resistentes ao tratamento usual. Método: Foi realizada uma pesquisa computadorizada da literatura no Medline utilizando as palavras "eletroconvulsoterapia", "estimulação magnética transcraniana ", "terapia magnética convulsiva", "estimulação do nervo vago" e "estimulação cerebral profunda", com todos os termos traduzidos para o idioma inglês. Referên-cias listadas em cada artigo foram também analisadas. Resultados: O desenvolvimento de novos tratamentos psiquiátricos não farmacológicos nas últimas décadas renovou o interesse em terapias somáticas. A despeito de a eletroconvulsoterapia continuar a ser o único tratamento somático com eficácia estabelecida, a estimulação magnética transcraniana, a terapia magnética convulsiva, a estimulação do nervo vago e a estimulação cerebral profunda são potencialmente novas modalidades de tratamento psiquiátrico. Conclusões: Novas modalidades de tratamento ainda padecem de falta de conhecimento cientifico adequado. Entretanto, estratégias somáticas ainda representam uma promessa como formas mais eficazes e seguras de tratamento psiquiátrico.

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Magnetic Seizure Therapy of Major Depression

Cited by 205 publications

References 18 publications

Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Affective Disorders

Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Affective Disorders

The Use of ECT and MST in treating depression

Terapias somáticas para transtornos psiquiátricos resistentes ao tratamento

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