Magnetic transducers in biosensors and bioassays

Larsson, Karin; Kriz, K; Kriz, Dario

doi:10.1051/analusis:1999270617

Cited by 33 publications

(15 citation statements)

References 22 publications

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“…Therefore, some interesting transduction methods in magnetic biosensing use magnetic remanence and/or relaxation [173,174,175,176], mixed excitation frequency response [177,178], cantilever movements (e.g. force amplified biological sensor, FABS) [179], inductance [180,181], induced current [182] or magnetoresistance, such as giant magnetoresistance (GMR) [183,184,185,186]. From these, the magnetoresistive techniques will be highlighted here due to the frequent combination of this technique with electrochemistry in biosensing.…”

Section: Magnetic Biosensorsmentioning

confidence: 99%

Electrochemical Biosensors - Sensor Principles and Architectures

Grieshaber

MacKenzie

Vörös

et al. 2008

Sensors

854

636

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Quantification of biological or biochemical processes are of utmost importance for medical, biological and biotechnological applications. However, converting the biological information to an easily processed electronic signal is challenging due to the complexity of connecting an electronic device directly to a biological environment. Electrochemical biosensors provide an attractive means to analyze the content of a biological sample due to the direct conversion of a biological event to an electronic signal. Over the past decades several sensing concepts and related devices have been developed. In this review, the most common traditional techniques, such as cyclic voltammetry, chronoamperometry, chronopotentiometry, impedance spectroscopy, and various field-effect transistor based methods are presented along with selected promising novel approaches, such as nanowire or magnetic nanoparticle-based biosensing. Additional measurement techniques, which have been shown useful in combination with electrochemical detection, are also summarized, such as the electrochemical versions of surface plasmon resonance, optical waveguide lightmode spectroscopy, ellipsometry, quartz crystal microbalance, and scanning probe microscopy. The signal transduction and the general performance of electrochemical sensors are often determined by the surface architectures that connect the sensing element to the biological sample at the nanometer scale. The most common surface modification techniques, the various electrochemical transduction mechanisms, and the choice of the recognition receptor molecules all influence the ultimate sensitivity of the sensor. New nanotechnology-based approaches, such as the use of engineered ion-channels in lipid bilayers, the encapsulation of enzymes into vesicles, polymersomes, or polyelectrolyte capsules provide additional possibilities for signal amplification. In particular, this review highlights the importance of the precise control over the delicate interplay between surface nano-architectures, surface functionalization and the chosen sensor transducer principle, as well as the usefulness of complementary characterization tools to interpret and to optimize the sensor response.

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Section: Magnetic Biosensorsmentioning

confidence: 99%

Electrochemical Biosensors - Sensor Principles and Architectures

Grieshaber

MacKenzie

Vörös

et al. 2008

Sensors

854

636

View full text Add to dashboard Cite

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“…Their size is typically between I and 10 J..lm. These materials normally contain metals such as iron, nickel or cobalt [27]. The use of monosized magnetic beads gives the convenience of magnetic separation.…”

Section: Introductionmentioning

confidence: 99%

An Overview to Magnetic Beads Used in Electrochemical DNA Biosensors

Wang

Erdem

2003

Nanostructured Materials and Coatings for Biomedical and Sensor Applications

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Nucleic acid layers combined with electrochemical or optical tr~msducers produce a new kind of affmity biosensors such as "DNA Biosensor" or "Ge:nosensor" for small molecular weight molecules. Electrochemical DNA biosensors are attractive devices for converting the hybridization event into an analytical signal for obtaining sequencespecific information in connection with clinical, environmental or forensic investigations. DNA hybridization biosensors, based on electrochemical transduction of hybridization, couple the high specificity of hybridization reactions with the excellent sensitivity and portability of electrochemical transducers. The ultimate goal in all research is to design DNA biosensors for preparing a basis for the future DNA microarray system. Recently, there has been an interest in magnetic beads for designing of new electrochemical DNA biosensor approaches resulting in efficient magnetic separation. Attractive features of this technology include simple approach, rapid results, multi-analyte detection, low-cost per measurument, stable, and nonhazardous reagents, and reduced waste handling. Some of these new approaches and applications of the electrochemical DNA biosensors based on magnetic beads are described and discussed.

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“…MMUNOMAGNETIC biosensors based on the use of superparamagnetic particles (MPs) as the biological markers have received strong interest for the detection and quantification of biological substances [1]- [3]. This interest is motivated by their potential for the development of systems with very high sensitivity, low cost, and high specificity.…”

mentioning

confidence: 99%

“…This interest is motivated by their potential for the development of systems with very high sensitivity, low cost, and high specificity. Among the different sensor strategies, different groups have proposed the use of inductive-based devices, where sensing is determined by the changes in the inductance of a solenoid due to the presence of the MPs in the sample under analysis [1], [4]- [6]. In relation to other magnetic immunoassays, these biosensors are characterized by their very high simplicity, since in this case, the application of permanent magnetic fields is not necessary for sensor operation.…”

mentioning

confidence: 99%

“…However, for very high-sensitivity applications, this approach is compromised by the stability required for the oscillator circuit. This has lead Kriz et al [1], [4] to use a modified Maxwell bridge in their sensor configuration. This is based on the measurement of the magnetic permeability of a sample formed by silica particles, which wear MPs that are immobilized on their surface through antigen-antibody-antigen sandwich complexes involving the analyte.…”

mentioning

confidence: 99%

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Microinductive Signal Conditioning With Resonant Differential Filters: High-Sensitivity Biodetection Applications

Baglio

Pérez-Rodrı́guez

Martı́nez

et al. 2007

IEEE Trans. Instrum. Meas.

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Abstract-Inductive-based devices integrated with Si technology for biodetection applications are characterized, using simple resonant differential filter configurations. This has allowed the corroboration of the viability of the proposed circuits, which are characterized by their very high simplicity, for microinductive signal conditioning in high-sensitivity sensor devices. The simulation of these simple circuits predicts sensitivities of the differential output voltage which can achieve values in the range of 0.1-1 V/nH, depending on the coil parameters. These very high-sensitivity values open the possibility for the experimental detection of extremely small inductance changes in the devices. For real microinductive devices, both series resistance and parasitic capacitive components contribute to the decrease of the differential circuit sensitivity. Nevertheless, measurements performed using microcoils fabricated with relatively high series resistance and coupling parasitic effects have allowed detection of changes in the range of 2 nH, which are compatible with biodetection applications with estimated detection limits below the picomolarity range.

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Magnetic transducers in biosensors and bioassays

Cited by 33 publications

References 22 publications

Electrochemical Biosensors - Sensor Principles and Architectures

Electrochemical Biosensors - Sensor Principles and Architectures

An Overview to Magnetic Beads Used in Electrochemical DNA Biosensors

Microinductive Signal Conditioning With Resonant Differential Filters: High-Sensitivity Biodetection Applications

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