With respect to bionomical concerns and energy security, the performance of refrigeration systems should be enriched, which can be done by improving the characteristics of working liquids. Nanoliquids have attracted interest in the fields of engineering and industry due to their prominent thermophysical characteristics. Researchers have used nanoliquids as working liquids and noticed significant fluctuations in thermal execution. In this study, our prime aim was to study the impact of thermal radiation and varying thermal conductivity on a cross‐nanofuid with the addition of a nonuniform heat sink–source, chemical process, and activation energy (AE) together with effects of assisting and opposing buoyancy. Furthermore, the relationship of zero‐mass flux together with the mechanism of thermophoresis and Brownian motion is considered. Traditionalistic transformations gave the ordinary differential equations (ODEs), which are further dealt with the approach of the Shooting Scheme to change the boundary value problem (BVP) into an initial value problem (IVP) and a numerical comparison is made with the Matlab solver package bvp4c. Bvp4c is based upon a collocation scheme, which yields numeric outcomes for nonlinear ODEs with IVP. Impacts of the involved parameters on mass transfer profile, heat, and momentum fields are shown through graphs. Mass transfer of the cross nanofluid increases with increasing values of AE parameter. Values of physical quantities like drag forces, rate of transport of heat and mass in the case of assisting/opposing flow are tabulated. The drag force magnitudes are greater for enhancing values of M, a, and n, while on the other hand, the opposing tendency is seen for We1 and We2. The magnitude of the rate of heat transport (Nusselt number) falls for greater values of m, σ, δ, and Nt, but in contrast, it accelerates for E, Pr, and n.