Magnolol and honokiol from Magnolia officinalis enhanced antiviral immune responses against grass carp reovirus in Ctenopharyngodon idella kidney cells

Chen, Xiaohui; Hu, Yang; Shan, Li-Peng; Yu, Xiaobo; Hao, Kai; Wang, Gao‐Xue

doi:10.1016/j.fsi.2017.02.020

Cited by 77 publications

(40 citation statements)

References 47 publications

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“…Our previous study proved that Mor was efficient to restrain the viral proliferation and safe to host cells (Yu, Chen, Ling, et al, ; Yu, Chen, Shan, et al, ). Particularly, this medicine has better antiviral efficacy than some others herbal medicines and pure compounds to CIK cells (Chen et al, ; Yu, Liu, et al, ). Nevertheless, the in vivo antiviral activity of Mor and the response of grass carp remain unknown in the treatment of GCRV‐inducing haemorrhagic disease.…”

Section: Discussionmentioning

confidence: 99%

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In vivo antiviral efficacy of moroxydine hydrochloride against grass carp reovirus and the drug safety assessment

Hao

Ling

et al. 2020

Aquac Res

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Our previous studies have verified that moroxydine hydrochloride (Mor) could inhibit replication of grass carp reovirus (GCRV) and suppress apoptosis of Ctenopharyngodon idella kidney cells, but be lack of information whether exists on antiviral activity in vivo. The paper was undertaken to explore the antiviral response of Mor against GCRV in grass carp and investigate the safety of drug for aquatic organisms. The results showed that injection treatment of Mor could more effectively inhibit GCRV replication than immersion administration. All the RNA systheses of vp3 and vp6 on day 7 in head kidney, gill, hepatopancreas and dorsal muscle in the Mor injection group were lesser than 0.07‐fold than that of in control group. And the GCRV‐inducing grass carp mortality was effectively controlled within 7 days post Mor injection therapy. Additionally, the reduction of superoxide dismutase activity, total antioxidant capacity and catalase activity in serum was effectively controlled by Mor. Moreover, drug safety assessment results showed that 500 mg/L of Mor was safe to C. idella, Bacillus subtilis, Chlorella vulgaris and Tetrahymena thermophila, which was far higher than the therapeutic concentration. The present study proved Mor as harmless formulations or products had potential value in the control of GCRV in aquaculture, with the advantage of super in vivo antiviral activity and environmental safety.

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Section: Discussionmentioning

confidence: 99%

“…Particularly, this medicine has better antiviral efficacy than some others herbal medicines and pure compounds to CIK cells (Chen et al, 2017;Yu, Liu, et al, 2014). Nevertheless, the in vivo antiviral activity of Mor and the response of grass carp remain unknown in the treatment of GCRV-inducing haemorrhagic disease.…”

Section: Discussionmentioning

confidence: 99%

In vivo antiviral efficacy of moroxydine hydrochloride against grass carp reovirus and the drug safety assessment

Hao

Ling

et al. 2020

Aquac Res

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“…Remarkably, the application of natural compounds to control viral disease in aquaculture has attracted increasing attention due to their demonstrable efficacy and low environmental hazard. Chen et al (2017) (Butt and Kanwal, 2011;Yau and Yoshida, 2014;Debing et al, 2014), including aquatic animal virus (Yu et al, 2016;Zhu et al, 2015). However, antiviral agent against SVCV is still scarce until now (Shao et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Evaluation on the antiviral activity of arctigenin against spring viraemia of carp virus

et al. 2018

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A B S T R A C TSpring viraemia of carp virus (SVCV) causes high morality in several economically important cyprinid fishes, but there is no approved therapy up to now. To address the urgent need for therapeutics to combat SVCV infection, we investigated the anti-SVCV activities of 12 natural compounds and 7 common antiviral agents using epithelioma papulosum cyprini (EPC) cells in this study. From the 19 compounds, we identified arctigenin (ARG) has the highest inhibition on SVCV replication, with maximum inhibitory percentage on SVCV > 90%. And the 48 h half maximal inhibitory concentrations (IC 50 ) of ARG on SVCV glycoprotein and nucleoprotein were 0.29 (0.22-0.39) and 0.35 (0.29-0.41) mg/L respectively. In addition, ARG significantly reduced SVCV-induced apoptosis and recovered SVCV-activated caspase-3/8/9 activity. Further, cellular morphological damage induced by SVCV was blocked by ARG treatment. Mechanistically, ARG did not affect SVCV infectivity. Moreover, ARG could not induce reactive oxygen species (ROS) generation, which plays an antiviral role on SVCV. Interestingly, SVCV-induced autophagy which is necessary for virus replication was inhibited by ARG treatment. These results indicated that the inhibition of ARG on SVCV replication was, at least in part, via blocking SVCVinduced autophagy. Taken together, ARG has the potential to work as an agent for protecting economically important fishes against SVCV.

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“…[ 27 ] The active ingredients of Magnolia officinalis Rehd. et Wils can strengthen innate immune signaling responses and modulate inflammation [ 28 , 29 ] ; whereas, the active ingredients of Poria cocos (Schw.) Wolf can regulate mammalian immune cells, with potential for use in treating Th2-mediated immune disorders.…”

Section: Introductionmentioning

confidence: 99%

Effects of Shuganjianpihuatanxingqi decoction on mild subclinical hypothyroidism

et al. 2018

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Introduction:Mild subclinical hypothyroidism (SCH) can cause depression, fatigue, cognitive dysfunction, or other hypothyroid symptoms, and even progress to hypothyroidism. The treatment of mild SCH is controversial. Shuganjianpihuatanxingqi decoction (SD) is a frequently prescribed Chinese herbal medicine in patients with mild SCH. However, scientific evidence is needed to confirm the therapeutic effect of SD.Methods and analysis:This study is a randomized, double-blind, and controlled clinical trial. A total of 228 participants with the diagnosis of mild SCH will be randomly assigned to the SD or placebo group in a ratio of 1:1. Participants will receive treatment for 12 weeks and undergo 12-month follow-up. The primary outcome measure is the thyroid-stimulating hormone level, and secondary outcomes will be the differences in the results of Thyroid-related Quality of Life Questionnaire, blood lipids, and Traditional Chinese Medicine Symptom Score Scale between baseline and at 12 weeks after intervention.Ethics and dissemination:The study has been approved by Guang’anmen Hospital of China Academy of Chinese Medical Sciences (no.2018-005-ky-01). The trial results will be published via peer-reviewed journals and the Clinical Research Information Service.Trial registration number:ChiCTR1800015781 (approval date: 20 April 2018).

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Magnolol and honokiol from Magnolia officinalis enhanced antiviral immune responses against grass carp reovirus in Ctenopharyngodon idella kidney cells

Cited by 77 publications

References 47 publications

In vivo antiviral efficacy of moroxydine hydrochloride against grass carp reovirus and the drug safety assessment

In vivo antiviral efficacy of moroxydine hydrochloride against grass carp reovirus and the drug safety assessment

Evaluation on the antiviral activity of arctigenin against spring viraemia of carp virus

Effects of Shuganjianpihuatanxingqi decoction on mild subclinical hypothyroidism

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