Maintenance of hematopoietic stem cell dormancy: yet another role for the macrophage

Gustafsson, Karin; Welsh, Michael J.

doi:10.21037/sci.2016.08.10

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Infiltrating Bone Marrow-derived Mps1

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2019

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“…As an example, in the bone marrow itself, MPs are required for correct hematopoiesis. Their depletion affects the HSC niche and induces HSC mobilization in the blood (Winkler et al, 2010;Gustafsson and Welsh, 2016). Moreover, MPs are also required to be in direct contact with erythroblasts in the bone marrow for proper erythropoiesis .…”

Section: Infiltrating Bone Marrow-derived Mpsmentioning

confidence: 99%

The origins and non-canonical functions of macrophages in development and regeneration

2019

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The discovery of new non-canonical (i.e. non-innate immune) functions of macrophages has been a recurring theme over the past 20 years. Indeed, it has emerged that macrophages can influence the development, homeostasis, maintenance and regeneration of many tissues and organs, including skeletal muscle, cardiac muscle, the brain and the liver, in part by acting directly on tissue-resident stem cells. In addition, macrophages play crucial roles in diseases such as obesity-associated diabetes or cancers. Increased knowledge of their regulatory roles within each tissue will therefore help us to better understand the full extent of their functions and could highlight new mechanisms modulating disease pathogenesis. In this Review, we discuss recent studies that have elucidated the developmental origins of various macrophage populations and summarize our knowledge of the non-canonical functions of macrophages in development, regeneration and tissue repair.

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Section: Infiltrating Bone Marrow-derived Mpsmentioning

confidence: 99%