Major Liver Resections Synchronous with Colorectal Surgery

Capussotti, Lorenzo; Ferrero, Alessandro; Viganò, Luca; Ribero, Dario; Tesoriere, Roberto Lo; Polastri, Roberto

doi:10.1245/s10434-006-9055-3

Cited by 180 publications

(164 citation statements)

References 26 publications

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“…Liver pedicle clamping can lead to an increased risk of anastomotic leakage because of the onset of intestinal edema (15,16). By laparoscopy, simultaneous resection for RCLM does not require occlusion of the whole hepatic inflow using hemihepatic vascular occlusion (17). Furthermore, the present series provided delayed coloanal anastomosis for patients with middle and low rectal tumor or poor general condition, who have a high prevalence of anastomotic leakage, while avoiding a prophylactic ileostomy.…”

Section: Discussionmentioning

confidence: 92%

“…Otherwise, left or right hemi-hepatectomy is another option. Recently, many studies (13,14,17) demonstrated that laparoscopic resection for rectal cancer, combined with synchronous resection of liver metastases, is a safe and feasible procedure in selected patients. With regard to liver metastases that are very difficult to resect with laparoscopy, the simultaneous open operation for liver metastasis is also a good option (16,18).…”

Section: Discussionmentioning

confidence: 99%

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The preliminary experience in simultaneous treatment of rectal cancer and synchronous liver metastases with laparoscopy

Zhu¹,

Tan²,

Tan³

et al. 2013

Turk J Gastroenterol

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

The preliminary experience in simultaneous treatment of rectal cancer and synchronous liver metastases with laparoscopy

Zhu¹,

Tan²,

Tan³

et al. 2013

Turk J Gastroenterol

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“…El índice de resecabilidad global fue de 77,6%, menor que en otras series de nuestro entorno y tal vez por eso, unido a que las intervenciones hepáticas fueron realizadas por el mismo cirujano, la morbilidad global es menor y no hemos tenido complicaciones mayores ni diferencias entre ambos grupos 4,7,12,15,[21][22][23]27,28 (Tabla 3), a pesar de que tenemos 46 pacientes ASA 3, por lo que no creemos que el status preoperatorio deba influir para elegir una u otra estrategia.…”

Section: Supervivenciaunclassified

Metástasis Hepáticas De Origen Colorrectal Sincrónicas: ¿intervención Simultánea O Secuencial?

et al. 2015

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simultaneous or sequential treatment of liver metastases of colon cancer? experience in 76 patientsBackground: Synchronous liver metastases of colon cancer can be managed with sequential or simultaneous surgical management of the primary tumor and the metastases. aim: To compare the evolution of patients whose liver metastases were treated sequentially or simultaneously. Material and Methods: Retrospective analysis of 76 patients aged 63 ± 11 years (67% males). In 25, metastases were managed simultaneously and in 51 there were treated sequentially after a period of chemotherapy. All interventions were performed by the same surgeon. results: Patients treated sequentially had a higher number of metastases and more lymph nodes involved than their counterparts treated simultaneously. The overall resectability index was 78%. Eighteen major and 28 minor hepatic resections were carried out. Significantly more major resections were carried out in the sequential treatment group. Mean hospital stay was 11 days and 20% of patients had complications, with no differences between groups. Survival at one, three and five years was 75, 45 and 36% in the simultaneous treatment and 76, 49 and 29% in the sequential treatment group (with no significant differences between groups). conclusions: In this group of patients no differences in complications or survival were observed when liver metastases were treated simultaneously or sequentially. However groups were not homogeneous.

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“…A systematic review of 16 controlled trials showed that the 5-year survival rates in patients with staged and synchronous resections are similar; however, the groups are not directly comparable and there are no randomized data [80]. Synchronous surgery has traditionally been limited to right-sided primaries and those with less extensive hepatic disease, but Capussotti et al [81] challenged this view with a report of safe and effective major hepatectomies for left-sided and rectal tumors. In that study of 79 patients, they found that the overall morbidity rate was higher (56.3% versus 32.6%; p ϭ .0369) and hospital stay was longer (20.5 days versus 13.9 days; p ϭ .00001) in the delayed surgery group when both procedures were considered together.…”

Section: What Is the Optimal Timing Of Liver Resection?mentioning

confidence: 99%

Curative Strategies for Liver Metastases from Colorectal Cancer: A Review

et al. 2012

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After completing this course, the reader will be able to:1. Among patients with liver metastases from colorectal cancer, determine which would benefit from liver resection, the timing for surgery, and an appropriate perioperative chemotherapy regimen.2. Determine which patients are candidates for perioperative chemotherapy and the appropriate timing of chemotherapy, and describe the relevant toxicities and their impact on morbidity and mortality.This article is available for continuing medical education credit at CME.TheOncologist.com. CME CME ABSTRACTColorectal cancer is a very common malignancy and frequently manifests with liver metastases, often without other systemic disease. Margin-negative (R0) resection of limited metastatic disease, in conjunction with systemic antineoplastic agents, is the primary treatment strategy, leading to long survival times for appropriately selected patients. There is debate over whether the primary tumor and secondaries should be removed at the same time or in a staged manner. Chemotherapy is effective in converting some unresectable liver metastases into resectable disease, with a correspondingly better survival outcome. However, the ideal chemotherapy with or without biological agents and when it should be administered in the course of treatment are uncertain. The role of neoadjuvant chemotherapy in initially resectable liver metastases is controversial. Local delivery of chemotherapy, with and without surgery, can lead to longer disease-free survival times, but it is not routinely used with curative intent. This review focuses on methods to maximize the disease-free survival interval using chemotherapy, surgery, and local methods. The Oncologist 2012;17:201-211

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Major Liver Resections Synchronous with Colorectal Surgery

Abstract: Major hepatectomies can be safely performed at the same time as colorectal surgery in selected patients with synchronous metastases with similar short-term results, even in the presence of rectal cancer.

Cited by 180 publications

References 26 publications

The preliminary experience in simultaneous treatment of rectal cancer and synchronous liver metastases with laparoscopy

The preliminary experience in simultaneous treatment of rectal cancer and synchronous liver metastases with laparoscopy

Metástasis Hepáticas De Origen Colorrectal Sincrónicas: ¿intervención Simultánea O Secuencial?

Curative Strategies for Liver Metastases from Colorectal Cancer: A Review

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