Major selected monoterpenes α-pinene and 1,8-cineole found in<i>Salvia lavandulifolia</i>(Spanish sage) essential oil as regulators of cellular redox balance

Porres-Martínez, María; González-Burgos, Elena; Carretero, M.E.; Gómez-Serranillos, M. Pilar

doi:10.3109/13880209.2014.950672

Cited by 75 publications

(53 citation statements)

References 32 publications

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“…This data is consistent with previous studies indicating that a-pinene suppresses ROS-induced lipid peroxidation in neuronal cell culture. [15] The attenuating effect of a-pinene on tissue levels of NO provides further evidence supporting the neuroprotective effect of a-pinene. NO is an indispensable reactive species which is mainly generated by inducible NOS enzyme in pathologic conditions, particularly in ischaemic stroke.…”

Section: Figurementioning

confidence: 84%

“…Accordingly, it can be indicated that the attenuating effect of α‐pinene on neuronal injury in the vulnerable regions of the brain could arise from improvement of the activity of antioxidant enzymes. These data are similar to those of Porres‐Martínez et al . who reported the protective effect of α‐pinene against H 2 O 2 ‐mediated oxidative stress in neuronal cell culture through restoring the function of antioxidant enzymes.…”

Section: Discussionmentioning

confidence: 99%

“…Based on the attained results, the administration of α‐pinene notably attenuated lipid peroxidation which was evident by a significant reduction in the concentration of MDA. This data is consistent with previous studies indicating that α‐pinene suppresses ROS‐induced lipid peroxidation in neuronal cell culture …”

Section: Discussionmentioning

confidence: 99%

“…For instance, it has been shown that treatment by α‐pinene enhances total antioxidant capacity of neurons in cell culture and lowers total oxidative stress levels in human lymphocytes . Recent studies have shown that α‐pinene attenuates ROS‐induced lipid peroxidation, while raise the protein expression of antioxidant enzymes including GPx, SOD and catalase . The inhibitory effect of α‐pinene on NO production has also been reported …”

Section: Introductionmentioning

confidence: 94%

“…[14] Recent studies have shown that a-pinene attenuates ROS-induced lipid peroxidation, while raise the protein expression of antioxidant enzymes including GPx, SOD and catalase. [15] The inhibitory effect of a-pinene on NO production has also been reported. [16,17] There is also evidence indicating that a-pinene function as an anti-inflammatory agent.…”

Section: Introductionmentioning

confidence: 99%

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Attenuating effect of α-pinene on neurobehavioural deficit, oxidative damage and inflammatory response following focal ischaemic stroke in rat

Khoshnazar

Bigdeli

Parvardeh

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives Oxidative stress and inflammation have a critical role in the pathogenesis of ischaemic stroke. Alpha‐pinene is a monoterpenoid molecule with anti‐inflammatory and antioxidant properties. The nobility of the present study was to evaluate the neuroprotective effect of α‐pinene in ischaemic stroke. Methods Ischaemic stroke was induced by transient middle cerebral artery occlusion followed by 24 h reperfusion in male Wistar rats. Alpha‐pinene (25, 50 and 100 mg/kg, i.p.) was administered in the beginning of reperfusion. Then, the neurobehavioural function, infarct volume, brain oedema, antioxidant enzyme activity and the concentration of malondialdehyde (MDA), nitric oxide (NO) and interleukin‐6 (IL‐6) were evaluated by different methods in the brain. Key findings Alpha‐pinene (50 and 100 mg/kg) elicited a significant decrease in the brain oedema and infarct size as well as an improvement in the neurobehavioural function. Besides, α‐pinene (100 mg/kg) restored the function of superoxide dismutase, catalase and glutathione peroxidase and reduced the concentration of MDA, NO and IL‐6 in the hippocampus, cortex and striatum. Conclusions It was ultimately attainted that α‐pinene exerts neuroprotective effect in ischaemic stroke in rat through the restoration of antioxidant enzymes activity, attenuation of lipid peroxidation and reduction of inflammation in the ischaemic brains.

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Section: Figurementioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Attenuating effect of α-pinene on neurobehavioural deficit, oxidative damage and inflammatory response following focal ischaemic stroke in rat

Khoshnazar

Bigdeli

Parvardeh

et al. 2019

Journal of Pharmacy and Pharmacology

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Profiling of Compositions of Essential Oils and Volatiles of Salvia limbata Using Traditional and Advanced Techniques and Evaluation for Biological Activities of Their Extracts

Mohammadhosseini

Akbarzadeh

Flamini

2017

Chemistry & Biodiversity

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In the present work, the essential oils and volatiles from flowers, leaves, and stems of Salvia limbata obtained using microwave-assisted hydrodistillation, solvent-free microwave extraction, headspace-assisted analysis, and headspace-solid phase microextraction have been characterized for the first time. The results have been also compared with those from traditional separation techniques involving hydrodistillation and steam distillation. Regardless of some common compounds in all of the profiles, some dissimilarities were noted due to the use of different extracting approaches. Taking into account the chemical categories, sesquiterpene hydrocarbons were found as the most represented group of natural compounds contributing to the chemical profiles. It was also noted that the methanol extracts obtained from the flowers of Sal. limbata showed a desirable antioxidant activity, comparable to the standard antioxidant butylated hydroxytoluene. Furthermore, using the disc diffusion and broth microdilution methods, all the tested bacteria demonstrated weak to moderate and moderate to strong sensibilities to the MeOH extracts obtained from different plant parts of Sal. limbata.

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Natural Monoterpenes: Much More than Only a Scent

Wojtunik-Kulesza

Kasprzak

Oniszczuk

et al. 2019

Chemistry & Biodiversity

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Terpenes are a widespread group of secondary metabolites that can be found in various family plants such as the Lamiaceae. In view of their numerous valuable biological activities, the industrial production of concrete terpenes and essential oils rich in the substances is intensively studied. Monoterpenes constitute a significant part of the whole group of the aforementioned secondary metabolites. This is due to their numerous biological activities and their ability to permeate the skin. Despite the fact that these substances have gain popularity, they are not comprehensively characterized. The presented review is based on studies of the biological activities of the most important monoterpenes and the essential oils rich in these compounds. The authors focused attention on antioxidant activity, inhibition towards acetyl-and butyrylcholinesterase, and α-amylase and α-glucosidase, antifungal, hepatoprotective, sedative properties, and their skin permeation enhancement.

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Major selected monoterpenes α-pinene and 1,8-cineole found inSalvia lavandulifolia(Spanish sage) essential oil as regulators of cellular redox balance

Cited by 75 publications

References 32 publications

Attenuating effect of α-pinene on neurobehavioural deficit, oxidative damage and inflammatory response following focal ischaemic stroke in rat

Attenuating effect of α-pinene on neurobehavioural deficit, oxidative damage and inflammatory response following focal ischaemic stroke in rat

Profiling of Compositions of Essential Oils and Volatiles of Salvia limbata Using Traditional and Advanced Techniques and Evaluation for Biological Activities of Their Extracts

Natural Monoterpenes: Much More than Only a Scent

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