Making headway towards understanding how epigenetic mechanisms contribute to early-life effects

Vukić, Maja; Wu, Haoyu; Daxinger, Lucia

doi:10.1098/rstb.2018.0126

Cited by 14 publications

(10 citation statements)

References 99 publications

(108 reference statements)

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“…SoC effect attenuation could also explain the lack of replication of SoC associations at the majority of CpGs from the discovery set. Importantly, this would have implications for detecting the effect of periconceptional exposures on DNAm in samples collected beyond the neonatal and early childhood periods, an important consideration for epigenetic epidemiological studies since non-persisting methylation differences could still have a significant impact on early developmental trajectories with life-long consequences 34,35 .…”

Section: Discussionmentioning

confidence: 99%

Environmentally sensitive hotspots in the methylome of the early human embryo

Silver

Saffari

Kessler

et al. 2019

Preprint

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In humans, DNA methylation marks inherited from sperm and egg are largely erased immediately following conception, prior to construction of the embryonic methylome. Exploiting a natural experiment of cyclical seasonal variation including changes in diet and nutritional status in rural Gambia, we replicated 134 loci with a common season-ofconception methylation signature in two independent child cohorts. These robust candidates for sensitivity to early environment were highly enriched for metastable epialleles, parent-of-origin specific methylation and regions hypomethylated in sperm. They tended to co-locate with endogenous retroviral (ERV1, ERVK) elements. Identified loci were influenced but not determined by measured genetic variation, notably through geneenvironment interactions. To the extent that early methylation changes impact gene expression, environmental sensitivity during genomic remethylation in the very early embryo could thus constitute a sense-record-adapt mechanism linking early environment to later phenotype. RESULTS Association of DNA methylation with Gambian season of conception

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Section: Discussionmentioning

confidence: 99%

Environmentally sensitive hotspots in the methylome of the early human embryo

Silver

Saffari

Kessler

et al. 2019

Preprint

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“…Continuing with this integrative approach, the issue then moves on to review the mechanisms that underlie the relationship between an environmental stimulus in early life and its long-term phenotypic consequences: in this context, Vukic et al [19] review how DNA methylation, histone modification and non-coding RNAs are the major epigenetic mechanisms that mediate gene regulation changes in response to environmental exposures. While the majority of these modifications are reset either during the development of the primordial germ cells or during early embryonal development [41], some modifications can survive this reprogramming stage, potentially paving the way for long-term inheritance (e.g.…”

Section: Overview Of the Issuementioning

confidence: 99%

“…Vukic et al [19], Baxter & Drake [20] and Groothuis et al [43] review findings where parents influence the phenotypes of their offspring or later descendants through epigenetic royalsocietypublishing.org/journal/rstb Phil. Trans.…”

Section: Overview Of the Issuementioning

confidence: 99%

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Developing differences: early-life effects and evolutionary medicine

Kuijper

Hanson

Vitikainen

et al. 2019

Phil. Trans. R. Soc. B

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Variation in early-life conditions can trigger developmental switches that lead to predictable individual differences in adult behaviour and physiology. Despite evidence for such early-life effects being widespread both in humans and throughout the animal kingdom, the evolutionary causes and consequences of this developmental plasticity remain unclear. The current issue aims to bring together studies of early-life effects from the fields of both evolutionary ecology and biomedicine to synthesise and advance current knowledge of how information is used during development, the mechanisms involved, and how early-life effects evolved. We hope this will stimulate further research into early-life effects, improving our understanding of why individuals differ and how this might influence their susceptibility to disease. This article is part of the theme issue ‘Developing differences: early-life effects and evolutionary medicine’.

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“…Figure 1 shows another epigenetic mechanism, histone acetylation, a permissive transcriptional mark that is regulated by histone acetyltransferases and deacetylases. 22,23 Major epigenomic features can now be interrogated comprehensively by combining molecular, cellular, and biochemical techniques exploring, for example, the mechanisms that enable host cells to react to environmental risk factors, and also the magnitude of the host response in the presence of bacterial biofilm challenge. 24 Thus, epigenetic variations have been proposed to contribute to personalized periodontal disease.…”

Section: Introductionmentioning

confidence: 99%

Epigenetic reprogramming in periodontal disease: Dynamic crosstalk with potential impact in oncogenesis

Barros

Fahimipour

Tarran

et al. 2019

Periodontology 2000

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Periodontitis is a chronic multifactorial inﬂammatory disease associated with microbial dysbiosis and characterized by progressive destruction of the periodontal tissues. Such chronic infectious inflammatory disease is recognized as a major public health problem worldwide with measurable impact in systemic health. It has become evident that the periodontal disease phenotypes are not only determined by the microbiome effect, but the extent of the tissue response is also driven by the host genome and epigenome patterns responding to various environmental exposures. More recently there is mounting evidence indicating that epigenetic reprogramming in response to combined intrinsic and environmental exposures, might be particularly relevant due its plasticity and potential application towards precision health. The complex epigenetic crosstalk is reflected in the prognosis and progress of periodontal diseases and may also lead to a favorable landscape for cancer development. This review discusses epigenomics modifications focusing on the role of DNA methylation and pathways linking microbial infection and inflammatory pathways, which are also associated with carcinogenesis. There is a more clear vision whereas 'omics' technologies applied to unveil relevant epigenetic factors could play a significant role in the treatment of periodontal disease in a personalized mode, evidencing that public health approach should coexist with precision individualized treatment.

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Making headway towards understanding how epigenetic mechanisms contribute to early-life effects

Cited by 14 publications

References 99 publications

Environmentally sensitive hotspots in the methylome of the early human embryo

Environmentally sensitive hotspots in the methylome of the early human embryo

Developing differences: early-life effects and evolutionary medicine

Epigenetic reprogramming in periodontal disease: Dynamic crosstalk with potential impact in oncogenesis

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