Malakoplakia

Wd, Biggar; Keating, Amy K.; Ra, Bear

doi:10.1097/00007890-198102000-00003

Cited by 56 publications

(5 citation statements)

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“…Another observation that is worth mentioning is that malakoplakia has been linked to a concurrent diagnosis of malignancy. Reported cases include urothelial carcinoma, bladder tumors, colon and prostate adenocarcinoma [11,12].…”

Section: Discussionmentioning

confidence: 99%

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Acute kidney injury secondary to obstructive bladder malakoplakia: a case report

et al. 2023

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Background Malakoplakia is a rare granulomatous inflammatory condition that can affect immunosuppressed patients. The genitourinary system is the most involved organ. We present a case of kidney failure caused by obstructing bladder lesions, clinically suspicious for malignancy and pathologically proven to be malakoplakia. Case presentation A 70-year-old woman presented with acute kidney injury and Escherichia coli (E.coli) bacteremia. Investigation showed bilateral hydronephrosis with thickening of the renal pelvises suggestive of urothelial malignancy. Cystourethroscopy revealed multiple bladder lesions completely obliterating both ureteral orifices. Pathology of the resected lesions confirmed the diagnosis of malakoplakia. Patient was treated with a prolonged antibiotic course over 6 months with recovery of her kidney function. Conclusion Malakoplakia can mimic invasive tumors, and the diagnosis is only attained through histopathology which uniquely demonstrates the pathognomonic Michaelis–Gutmann inclusions inside sheets of histiocytes. Treatment is largely dependent on prolonged antibiotics therapy that must cover the most common isolated pathogen, E.coli.

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Section: Discussionmentioning

confidence: 99%

“…Ultimately, the accumulated bacterial fragments in the lysosomes get mineralized by iron and calcium depositions, forming the characteristic pathognomonic Michaelis-Gutmann bodies [4,13]. This most likely explains why malakoplakia is more seen in immunocompromised patients, due to their altered immune system [12].…”

Section: Discussionmentioning

confidence: 99%

Acute kidney injury secondary to obstructive bladder malakoplakia: a case report

et al. 2023

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“…In conclusion, the diagnosis of malacoplakia is based on a combination of clinical presentation; imaging studies, such as ultrasound; and histological examination of affected tissues. Endometrial malacoplakia typically presents with postmenopausal bleeding, abnormal uterine bleeding in menstruating women, or a suspicious uterine mass [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. Our case is the first of malacoplakia presenting with abundant vaginal sero-hematic secretions months after surgery for a cesarean section.…”

Section: Table 1: Summary Of the Previous Cases Reported In Literatur...mentioning

confidence: 99%

“…This is likely due to defective lysosomal function, leading to the formation of von Hansemann cells, a characteristic histological finding in malakoplakia [3][4][5][6][7][8][9][10][11][12][13][14]. Involvement of the female genital tract is rare, with less than 40 cases reported to date, of which only 15 cases of endometrium malacoplakia [4][5][6][7][8][9][10][11][12][13][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Tracking Endometrial Malacoplakia Through the Evolution of 2D and 3D Ultrasound and Histopathological Features

Vimercati,

Cirignaco,

De Nola

et al. 2024

Cureus

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Malacoplakia is an uncommon disease characterized by chronic and granulomatous inflammation, which rarely involves the female genital tract. We describe the ecographic and histological evolution of the first case of a patient developing endometrial malacoplakia as a complication after a cesarean section. The patient, a 43-year-old woman, presented with pelvic pain one month after delivering by cesarean section and the initial suspicion was of retention of placental rests. We discuss the diagnostic challenges for this rare disease, highlighting the importance of considering endometrial malacoplakia as a possible diagnosis in patients with similar clinical presentations and the important role of 2D and 3D ultrasound in the diagnostic pathway. In literature, ultrasound findings in cases of endometrial malacoplakia are represented by hypoechoic thickening of the endometrial lining; hyperechoic thickening of the myometrium, and the presence of masses, nodules, cystic areas, or anechoic fluid within the endometrium. For the first time, we describe the evolution of endometrial malacoplakia through both ultrasound, 2D and 3D, and histopathological findings, from the acute to chronic stage of the disease.

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“…inappropriate blame and political cynicism." 23 At the same time, when governments are unable to secure the rights of their citizens, Biggar allows that they should still be upheld as "ideals of maximal security against risks to important freedoms, to which fragile governments, with aid from international partners, should approximate as circumstances allow." If rights are conditional upon their feasibility, though, then this concession to "ideals" seems to fall prey to Biggar's criticisms of rights-as-abstractions.…”

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confidence: 99%