Malakoplakia of the large intestine found incidentally at necropsy

Chaudhry, A P; Saigal, Krishna P.; Intengan, Marilyn; Nickerson, Peter A.

doi:10.1007/bf02586764

Cited by 28 publications

(14 citation statements)

References 37 publications

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“…1 Within these histiocytes are the hallmark "targetlike" structures-basophilic, periodic acid-Schiff (PAS)-positive, diastase-resistant and von Kossa-positive calcospherules, known as Michaelis-Gutmann bodies-which are found both intra-and extracellularly. 2 The calcospherules are remnants of defective phagolysosomes in macrophages that are unable to completely degrade bacteria and eventually become mineralized by calcium phosphate crystals.…”

mentioning

confidence: 99%

Rectal and Cutaneous Malakoplakia in an Orthotopic Cardiac Transplant Recipient

Teeters

Betts

Ryan

et al. 2007

The Journal of Heart and Lung Transplantation

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mentioning

confidence: 99%

Rectal and Cutaneous Malakoplakia in an Orthotopic Cardiac Transplant Recipient

Teeters

Betts

Ryan

et al. 2007

The Journal of Heart and Lung Transplantation

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“…It has also been established that EET metabolites of AA produced by the endothelium are potent vasodilators and natriuretic agents and are proposed as endotheliumderived hyperpolarizing factors 39 . Degradation of these metabolites by sEH led to more research interest towards inhibiting this enzyme as an avenue to increase EETs levels and prevent progression of hypertension 40 .…”

Section: Discussionmentioning

confidence: 99%

Modulation of Arachidonic Acid Metabolism in the Rat Kidney by Resveratrol: Implications for Regulation of Blood Pressure

Elbarbry¹,

Vermehren²,

Rao³

2015

Pharmacologia

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Background and Objective:The objective of this study was to investigate the effects of resveratrol (RES) on Arachidonic acid (AA) metabolism in the kidney and its effect on arterial blood pressure, using spontaneously hypertensive rats (SHR) as a model system. Methods: Rats were exposed to either drinking water alone (control) or RES (20 or 40 mg kgG 1 ) added to drinking water for 7 weeks. Mean Arterial Pressure (MAP) was measured at 7-day intervals throughout the study. At the end of treatment, rats were euthanized, followed by preparation of kidney microsomes to measure enzymes involved in regulation of vasoactive metabolites: CYP4A, the key enzyme in the formation of 20-hydroxyeicosatetraenoic acid and the soluble epoxide hydrolase, which is responsible for the degradation of the vasodilator metabolites such as epoxyeicosatetraenoic acids. Effect of RES on kidney expression of CYP4A was also investigated by immunoblotting. Results: Treatment with RES resisted the progressive rise in MAP in the developing SHR in a dose-dependent manner. Consistent with these data, RES treatment led to significant reductions in both, the expression and activity of renal CYP4A isozymes, as well as the activity of soluble epoxide hydrolase (sEH). Conclusion: The presented studies show that RES modulates the metabolism of AA by both P450 enzymes and sEH in SHR rats, which may represent a novel mechanism by which RES protects SHR rats against the progressive rise in blood pressure.

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“…In addition to the 3 cases of colonic malakoplakia described Kuzma, 1967;Rwylin, Ravel and Hurwitz, 1969;Blackshear, 1970;DiSilvio and Bartlett, 1971;Dockerty, 1972;Filotico and Renda, 1971;Birkenstock and Louw, 1972;Ranchod and Kahn, 1972;Wilkey and Rubel, 1972;De La Garza et al, 1973;Galian et al, 1973;Lou and Teplitz, 1973;Lewin et al, 1974;Robert, Lagace and Delage, 1974;Sanusi and Tio, 1974;Clarke, Korbel and Maher, 1975;Scheiner et al, 1975;Sinclair-Smith, Kahn and Cywes, 1975;Taghinia and Amiri, 1976;Joyeuse et al, 1977;Boixeda, Hernandez Ranz and Moreira, 1978;MacKay, 1978;Nakabayashi et al, 1978;Chaudhry et al, 1979). The presented data on each case are of variable completeness.…”

Section: Review Of the Literature And Discussionmentioning

confidence: 99%

“…'Reticulum cell sarcoma' (Galian et al, 1973) and diffuse lymphocytic lymphoma (Lewin et al, 1974) were each known to be present in one case and the clinical impression was that of involvement of the gastrointestinal tract by these diseases. Alcoholic cirrhosis with bleeding oesophageal varices were suspected in one case (Chaudhry et al, 1979), In only one instance was malakoplakia diagnosed by biopsy before major therapeutic intervention.…”

Section: Review Of the Literature And Discussionmentioning

confidence: 99%

Malakoplakia of the gastrointestinal tract

McClure

1981

Postgraduate Medical Journal

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Summary The clinical and pathological features of 3 cases of colonic malakoplakia are documented thereby bringing to 34 the total of recorded cases of malakoplakia involving the gastrointestinal tract. This is therefore the most common site of involvement outside the urogenital tract. A comprehensive review of the world literature on gastrointestinal malakoplakia has been made and the characteristic features of the condition have been delineated. There was a bimodal age incidence with a small cluster of cases occurring in childhood and associated with significant additional systemic disease. In the adult cases the average age was 57 years with a slight excess of males. The most commonly involved part of the gastrointestinal tract was the colon and colonic carcinoma was the most common associated disease.

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Malakoplakia of the large intestine found incidentally at necropsy

Cited by 28 publications

References 37 publications

Rectal and Cutaneous Malakoplakia in an Orthotopic Cardiac Transplant Recipient

Rectal and Cutaneous Malakoplakia in an Orthotopic Cardiac Transplant Recipient

Modulation of Arachidonic Acid Metabolism in the Rat Kidney by Resveratrol: Implications for Regulation of Blood Pressure

Malakoplakia of the gastrointestinal tract

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