Malaria is a life-threatening disease caused by the parasite. It could be a major public health problem in Pakistan due to poor hygienic conditions; malnutrition borne non-defensive immunity system. The purpose of study was to examine possible changes in electrolytes level of patients with malaria. Serum electrolytes were determined by using appropriate techniques. The result showed a significant elevation in the levels of sodium (Na) and potassium (K), whereas, chloride decreases statistically in malarial patients compared to those of controls. The blood serum electrolyte level obtained for sodium was 135.55 ppm, potassium was 4.044 ppm, and for chloride was 10.33 ppm and those for the controls determined to be 130.88 ppm, 3.98 ppm and 104.5 ppm respectively.The concentration of serum electrolytes was in range of abnormal level which could lead our study towards the conclusion that the increased levels of sodium and potassium can be maintained by giving supplement.