Male contribution in the constitution of the Brazilian Centro-Oeste population estimated by Y-chromosome binary markers

Barcelos, R.S.S.; Ribeiro, Gustavo Lins; Silva, W.; Abe‐Sandes, Kiyoko; Godinho, Neide M. O.; Marinho-Neto, F.; Gigonzac, Marc Alexandre Duarte; Klautau-Guimarães, M. N.; Oliveira, Silviene Fabiana de

doi:10.1016/j.ics.2005.11.109

Cited by 7 publications

(3 citation statements)

References 4 publications

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“…Marrero et al (14) also reported evidence of admixture in Native American populations, showing the presence of non-Amerindian haplotypes in Kaingang and Guarani peoples (14). Finally, numerous studies analyzing Y-chromosome haplogroups reinforce the miscegenation addressed in this article, pointing to European, Amerindian, African and Asian haplogroups in different ethnicities and population groups from different Brazilian regions (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28).…”

Section: Introduction Genetic Aspects Of the Brazilian Populationsupporting

confidence: 60%

CCR5Δ32 in Brazil: Impacts of a European Genetic Variant on a Highly Admixed Population

Kulmann-Leal

Ellwanger

2021

Front. Immunol.

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The genetic background of Brazilians encompasses Amerindian, African, and European components as a result of the colonization of an already Amerindian inhabited region by Europeans, associated to a massive influx of Africans. Other migratory flows introduced into the Brazilian population genetic components from Asia and the Middle East. Currently, Brazil has a highly admixed population and, therefore, the study of genetic factors in the context of health or disease in Brazil is a challenging and remarkably interesting subject. This phenomenon is exemplified by the genetic variant CCR5Δ32, a 32 base-pair deletion in the CCR5 gene. CCR5Δ32 originated in Europe, but the time of origin as well as the selective pressures that allowed the maintenance of this variant and the establishment of its current frequencies in the different human populations is still a field of debates. Due to its origin, the CCR5Δ32 allele frequency is high in European-derived populations (~10%) and low in Asian and African native human populations. In Brazil, the CCR5Δ32 allele frequency is intermediate (4-6%) and varies on the Brazilian States, depending on the migratory history of each region. CCR5 is a protein that regulates the activity of several immune cells, also acting as the main HIV-1 co-receptor. The CCR5 expression is influenced by CCR5Δ32 genotypes. No CCR5 expression is observed in CCR5Δ32 homozygous individuals. Thus, the CCR5Δ32 has particular effects on different diseases. At the population level, the effect that CCR5Δ32 has on European populations may be different than that observed in highly admixed populations. Besides less evident due to its low frequency in admixed groups, the effect of the CCR5Δ32 variant may be affected by other genetic traits. Understanding the effects of CCR5Δ32 on Brazilians is essential to predict the potential use of pharmacological CCR5 modulators in Brazil. Therefore, this study reviews the impacts of the CCR5Δ32 on the Brazilian population, considering infectious diseases, inflammatory conditions, and cancer. Finally, this article provides a general discussion concerning the impacts of a European-derived variant, the CCR5Δ32, on a highly admixed population.

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Section: Introduction Genetic Aspects Of the Brazilian Populationsupporting

confidence: 60%

CCR5Δ32 in Brazil: Impacts of a European Genetic Variant on a Highly Admixed Population

Kulmann-Leal

Ellwanger

2021

Front. Immunol.

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“…The Brazilian population is very mixed, primarily as a result of five centuries of interethnic crosses among Europeans, Africans and Amerindians. This three-hybrid genetic admixture has been demonstrated by genetic and historical studies ( Callegari-Jacques and Salzano, 1999 ; Alves-Silva et al , 2000 ; Carvalho-Silva et al , 2001 ; Mendes-Junior and Simões, 2001 ; Callegari-Jacques et al , 2003 ; Barcelos et al , 2006a , b ; Suarez-Kurtz et al , 2007 ; Godinho et al , 2008 ). Haptoglobin is one of the genetic markers used to describe the genetic constitution of populations.…”

Section: Introductionmentioning

confidence: 69%

Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities

et al. 2009

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Haptoglobin is a plasma hemoglobin-binding protein that limits iron loss during normal erythrocyte turnover and hemolysis, thereby preventing oxidative damage mediated by iron excess in the circulation. Haptoglobin polymorphism in humans, characterized by the Hp*1 and Hp *2 alleles, results in distinct phenotypes known as Hp1-1, Hp2-1 and Hp2-2, whose frequencies vary according to the ethnic origin of the population. The Hp*1 allele has two subtypes, Hp *1F and Hp *1S , that also vary in their frequencies among populations worldwide. In this work, we examined the distribution frequencies of haptoglobin subtypes in three Brazilian population groups of different ethnicities. The haptoglobin genotypes of Kayabi Amerindians (n = 56), Kalunga Afro-descendants (n = 70) and an urban population (n = 132) were determined by allele-specific PCR. The Hp*1F allele frequency was highest in Kalunga (29.3%) and lowest in Kayabi (2.6%). The Hp*1F/Hp*1S allele frequency ratios were 0.6, 1.0 and 0.26 for the Kayabi, Kalunga and urban populations, respectively. This variation was attributable largely to the Hp*1F allele. However, despite the large variation in Hp*1F frequencies, results of F ST (0.0291) indicated slight genetic differentiation among subpopulations of the general Brazilian population studied here. This is the first Brazilian report of variations in the Hp*1F and Hp*1S frequencies among non-Amerindian Brazilians.

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“…In 1960, the capital of Brazil was relocated from Rio de Janeiro to Federal District, in the Middle-West region. Due to the recent migration, the Federal District is considered as the population that mostly represents Brazilian population as a whole [5].…”

Section: Introductionmentioning

confidence: 99%

DRD2TaqI haplotypes in three urban Brazilian populations

Arcanjo

Dalton

Godinho³

et al. 2009

Forensic Science International: Genetics Supplement Series

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Male contribution in the constitution of the Brazilian Centro-Oeste population estimated by Y-chromosome binary markers

Cited by 7 publications

References 4 publications

CCR5Δ32 in Brazil: Impacts of a European Genetic Variant on a Highly Admixed Population

CCR5Δ32 in Brazil: Impacts of a European Genetic Variant on a Highly Admixed Population

Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities

DRD2TaqI haplotypes in three urban Brazilian populations

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