Male infertility is the problem of the XXI century

Khayrutdinov, K. N.; Ситдыкова, М. Э.; Zubkov, A. Yu.

doi:10.32000/2072-1757-2018-16-6-185-189

Cited by 7 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, active clinical pathophysiological studies of autoimmunity as a mechanistic factor contributing to the formation of male infertility began after 1965 [ 35 , 36 ]. In recent decades, an immunological form of infertility has attracted more attention due to the establishment of the role of ASAs as a direct cause of infertility, since higher levels and incidence of ASAs were diagnosed in infertile men compared to healthy ones [ 13 , 37 , 38 , 39 , 40 , 41 ]. Nowadays, there is an opinion that a pathologically enhanced autoreactive immune response to the antigens of the reproductive system can lead to infertility, and ASAs are valid immunological markers valid for the assessment of impaired male fertility [ 29 , 39 , 40 , 41 ].…”

Section: Sperm Antigens and Antisperm Antibodies (Asas): Past And Pre...mentioning

confidence: 99%

“…Nowadays, there is an opinion that a pathologically enhanced autoreactive immune response to the antigens of the reproductive system can lead to infertility, and ASAs are valid immunological markers valid for the assessment of impaired male fertility [ 29 , 39 , 40 , 41 ]. ASAs is determined in 10% of infertile men, and the frequency of the immunological form of infertility is 4.5–15% in various populations [ 2 , 7 , 13 , 41 , 42 , 43 , 44 , 45 ].…”

Section: Sperm Antigens and Antisperm Antibodies (Asas): Past And Pre...mentioning

confidence: 99%

“…The reproductive potential of the world male population is declining steadily and there is no tendency for improvement [ 7 , 8 , 9 , 10 , 11 ]. The etiology of male infertility is still a matter of debate among various specialists, but the influence of both exogenous and endogenous factors is noticed, combining negative effects on spermatogenesis and various stages of the fertilization [ 12 , 13 ]. Hence, male infertility is a multifactorial syndrome that includes a wide range of disorders, affecting not only the reproductive system, but also the immunoneuroendocrine apparatus [ 10 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine, and Endocrine Dysregulation

Черешнев

Pichugova

Beikin³

et al. 2021

Pathophysiology

View full text Add to dashboard Cite

According to global data, there is a male reproductive potential decrease. Pathogenesis of male infertility is often associated with autoimmunity towards sperm antigens essential for fertilization. Antisperm autoantibodies (ASAs) have immobilizing and cytotoxic properties, impairing spermatogenesis, causing sperm agglutination, altering spermatozoa motility and acrosomal reaction, and thus preventing ovum fertilization. Infertility diagnosis requires a mandatory check for the ASAs. The concept of the blood–testis barrier is currently re-formulated, with an emphasis on informational paracrine and juxtacrine effects, rather than simple anatomical separation. The etiology of male infertility includes both autoimmune and non-autoimmune diseases but equally develops through autoimmune links of pathogenesis. Varicocele commonly leads to infertility due to testicular ischemic damage, venous stasis, local hyperthermia, and hypoandrogenism. However, varicocelectomy can alter the blood–testis barrier, facilitating ASAs production as well. There are contradictory data on the role of ASAs in the pathogenesis of varicocele-related infertility. Infection and inflammation both promote ASAs production due to “danger concept” mechanisms and because of antigen mimicry. Systemic pro-autoimmune influences like hyperprolactinemia, hypoandrogenism, and hypothyroidism also facilitate ASAs production. The diagnostic value of various ASAs has not yet been clearly attributed, and their cut-levels have not been determined in sera nor in ejaculate. The assessment of the autoimmunity role in the pathogenesis of male infertility is ambiguous, so the purpose of this review is to show the effects of ASAs on the pathogenesis of male infertility.

show abstract

Section: Sperm Antigens and Antisperm Antibodies (Asas): Past And Pre...mentioning

confidence: 99%

Section: Sperm Antigens and Antisperm Antibodies (Asas): Past And Pre...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine, and Endocrine Dysregulation

Черешнев

Pichugova

Beikin³

et al. 2021

Pathophysiology

View full text Add to dashboard Cite

show abstract

“…But active clinical pathophysiological studies of autoimmunity as a mechanistic factor contributing to the formation of male infertility began after 1965 [35,36]. In recent decades, immunological form of infertility attracted more attention due to establishment of the role of ASAs as a direct cause of infertility, since a higher levels and incidence of ASAs were diagnosed in infertile men compared to healthy ones [13,[37][38][39][40][41]. Nowadays there is an opinion that pathologically enhanced autoreactive immune response to the antigens of reproductive system can lead to infertility, and ASAs are the immunological markers valid for assessment of impaired male fertility [29,[39][40][41].…”

Section: Sperm Antigens and Antisperm Antibodies (Asas): Past And Presentmentioning

confidence: 99%

“…The reproductive potential of the world male population is declining steadily and there is no tendency to improvement [7][8][9][10][11]. The etiology of male infertility is still a matter of debate among various specialists, but influence of both exogenous and endogenous factors is noticed, combining negative effects on spermatogenesis and various stages of the fertilization [12,13]. Hence, male infertility is a multifactorial syndrome that includes a wide range of disorders, affecting not only the reproductive system, but also the immunoneuroendocrine apparatus [10,14,15].…”

Section: Introductionmentioning

confidence: 99%

Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine and Endocrine Deregulation

Черешнев¹,

Pichugova²,

Beikin³

et al. 2021

Preprint

View full text Add to dashboard Cite

According to global data, there is a male reproductive potential decrease. Pathogenesis of male infertility often is associated with autoimmunity towards sperm antigens essential for fertilization. Antisperm autoantibodies (ASAs) have immobilizing and cytotoxic properties, impairing spermatogenesis, causing sperm agglutination, altering spermatozoa motility and acrosomal reaction, thus preventing ovum fertilization. Infertility diagnosis requires mandatory check for the ASAs. The concept of blood-testis barrier currently is re-formulated with emphasis of informational paracrine and juxtacrine effects, rather than simple anatomical separation. Aetiology of male infertility includes both autoimmune and non-autoimmune diseases, but equally develops through autoimmune links of pathogenesis. Varicocele commonly leads to infertility due to testicular ischemic damage, venous stasis, local hyperthermia, and hypoandrogenism. However, varicocelectomy can alter blood-testis barrier facilitating ASAs production as well. There are contradictory data on the role of ASAs in pathogenesis of varicocele-related infertility. Infection and inflammation both promote ASAs production due to “danger concept” mechanisms and because of antigen mimicry. Systemic pro-autoimmune influences like hyperprolactinemia, hypoandrogenism and hypothyroidism also facilitate ASAs production. Diagnostic value of various ASAs was not yet clearly attributed, and their cut-levels not agreed neither in sera nor in ejaculate. The assessment of the autoimmunity role in pathogenesis of male infertility is ambiguous.

show abstract

Evaluation of cytokine profile of ejaculate in adolescents with varicocele

2023

View full text Add to dashboard Cite

Varicocele is a vascular disease characterized by abnormal tortuosity and dilation of the veins in pampiniform plexus that drains the testis. Due to difficult outflow of blood via the altered veins, the intratesticular blood flow becomes impaired, leading to pathological changes in the testicular tissue caused by hyperthermia, ischemia, hypoxia and development of inflammatory reaction. Seminal plasma contains numerous proteins, molecules, a wide range of cytokines, chemokines, growth factors. Their properties and levels largely determine the stages of post-testicular maturation of spermatozoa. At the same time, cytokines are an integral part of the inflammatory effect and are synthesized by various immunocompetent cells present in the male reproductive tract. Increased cytokine levels in ejaculate may act as a marker of local inflammatory process, being a significant factor of male infertility. The purpose of our study was to assess cytokine profile of ejaculate in adolescents with varicocele.The level of cytokines IL-1β, IL-6, IL-8, TNFα, IL-4, IL-10, VEGF was determined in ejaculate of adolescents aged 17 years. The main group consisted of 100 adolescents with II-III degree varicocele; the comparison group included 30 adolescents without varicocele.Adolescents with varicocele have statistically higher levels of all studied pro-inflammatory cytokines, except of IL-8 and IL-10, which may suggest presence of a local inflammatory process. We did not find significant differences in the levels of cytokines between groups with grade II and III varicocele. However, the levels of pro-inflammatory IL-1β, IL-6 cytokines in ejaculate proved to be increased in the patients with grade III varicocele. When comparing the results between both groups, depending on the period after varicocelectomy and in the comparison group, statistically higher levels of IL-1β, IL-6, TNFα were detected in patients with more recent surgical correction and IL-10 levels in both subgroups with varicocele. This finding, given the progressive course of this disease, may be considered an unfavorable factor, since the pro-inflammatory status of testicular tissue returned, at later terms after surgery.In adolescentswith varicocele, increased levels of pro-inflammatory cytokineswere revealed in the ejaculate. There were no statistically significant differences in the level of cytokines in ejaculate of the patients with II and III degrees of varicocele. At the longer postsurgical period, an increased level of pro-inflammatory cytokines was revealed in the ejaculate samples.

show abstract

Male infertility is the problem of the XXI century

Cited by 7 publications

References 0 publications

Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine, and Endocrine Dysregulation

Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine, and Endocrine Dysregulation

Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine and Endocrine Deregulation

Evaluation of cytokine profile of ejaculate in adolescents with varicocele

Contact Info

Product

Resources

About