Male rats with the testicular feminization mutation of the androgen receptor display elevated anxiety-related behavior and corticosterone response to mild stress

Zuloaga, Damian G.; Poort, Jessica E.; Jordan, Cynthia L.; Breedlove, S. Marc

doi:10.1016/j.yhbeh.2011.07.008

Cited by 58 publications

(50 citation statements)

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“…Alternatively, measures of anxiety on a third indicator of rodent anxiety, the light-dark box task, agree across rats and mice with both species displaying higher anxiety-like behaviour in TFM males compared to wild-type males (Figure 1) (Zuloaga et al, 2011a;Zuloaga et al, 2008;Zuloaga et al, 2011b). Overall, male TFM rats consistently displayed higher levels of anxiety-like behaviours compared to wild-type control males, while the effects of androgen insensitivity in male TFM mice is less consistent.…”

Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 91%

“…Inconsistencies were apparent as well in terms of the TFM rodent model. Though both rats and mice exhibited increased anxiety on the light-dark box, differences between rats and mice were apparent on other anxiety tasks and measures of anhedonic depression (Hamson et al, 2014;Zuloaga et al, 2011a;Zuloaga et al, 2008;Zuloaga et al, 2011b). In…”

Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 91%

“…Studies document higher anxiety-like behaviour on the elevated plus maze in TFM rats (Hamson et al, 2014;Zuloaga et al, 2011b), a behavioural difference that was not apparent in mice with the same mutation (Zuloaga et al, 2008). Similarly, on another task of anxiety, TFM rats displayed higher anxiety-like behaviour compared to their wild type counterparts, on the open-field task (Zuloaga et al, 2011a;Zuloaga et al, 2011b), an effect that again Hormonal contribution to affective psychopathologies across species 22…”

Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 93%

“…In this model, TFM rats or mice carry a genetic mutation of the androgen receptor, resulting in insensitivity to androgens. Investigations of the affective behaviours characteristic of TFM male rodents compared to their wild-type counterparts revealed higher anxiety-like behaviours in TFM animals (Hamson et al, 2014;Rizk et al, 2005;Zuloaga et al, 2011a;Zuloaga et al, 2011b). Studies document higher anxiety-like behaviour on the elevated plus maze in TFM rats (Hamson et al, 2014;Zuloaga et al, 2011b), a behavioural difference that was not apparent in mice with the same mutation (Zuloaga et al, 2008).…”

Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 96%

“…Investigations of the affective behaviours characteristic of TFM male rodents compared to their wild-type counterparts revealed higher anxiety-like behaviours in TFM animals (Hamson et al, 2014;Rizk et al, 2005;Zuloaga et al, 2011a;Zuloaga et al, 2011b). Studies document higher anxiety-like behaviour on the elevated plus maze in TFM rats (Hamson et al, 2014;Zuloaga et al, 2011b), a behavioural difference that was not apparent in mice with the same mutation (Zuloaga et al, 2008). Similarly, on another task of anxiety, TFM rats displayed higher anxiety-like behaviour compared to their wild type counterparts, on the open-field task (Zuloaga et al, 2011a;Zuloaga et al, 2011b), an effect that again Hormonal contribution to affective psychopathologies across species 22…”

Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 99%

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Assessing gonadal hormone contributions to affective psychopathologies across humans and animal models

Mueller

Grissom

Dohanich

2014

Psychoneuroendocrinology

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Despite increasing acknowledgement of hormonal contributions to mood and anxiety disorders, the underlying mechanisms by which gonadal hormones influence psychopathology-related behaviours remain unknown. This review focuses on recent research that examines the influence of gonadal steroid hormones, including androgens, estrogens, and progesterone, on mood and anxiety-related behaviours in human health and disease. To this aim, the literature was surveyed for studies that assess conditions with suspected underlying hormonal imbalances in otherwise healthy participants (e.g., Premenstrual Dysphoric Disorder, Postmenopausal Depression,) as well as conditions linked to congenital endocrine abormalities (e.g., Turner Syndrome, Klinefelter Syndrome, Polycystic Ovary Syndrome, Congenital Adrenal Hyperplasia, Familial Male Precocious Puberty, Androgen Insensitivity Syndrome). Furthermore, to better inform clinical work and to create a translational bridge, a second goal was to set human psychopathologies and animal models of these conditions side-by-side. In the second part of the review, based on consistencies revealed in the existing literature across conditions, a new model for the impact of gonadal hormones on anxious and depressed behavioural states is proposed. Finally, we conclude by proposing directions for future research, including the development of specific tasks suitable for cross-species comparisons to increase our knowledge of the role of gonadal hormones in mood and anxiety.

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Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 91%

Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 91%

Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 93%

Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 96%

Section: Hormonal Contribution To Affective Psychopathologies Across mentioning

confidence: 99%

See 3 more Smart Citations

Assessing gonadal hormone contributions to affective psychopathologies across humans and animal models

Mueller

Grissom

Dohanich

2014

Psychoneuroendocrinology

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Sex Differences in the HPA Axis

Goel

Workman

Lee

et al. 2014

Comprehensive Physiology

342

198

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The hypothalamic-pituitary-adrenal (HPA) axis is a major component of the systems that respond to stress, by coordinating the neuroendocrine and autonomic responses. Tightly controlled regulation of HPA responses is critical for maintaining mental and physical health, as hyper- and hypo-activity have been linked to disease states. A long history of research has revealed sex differences in numerous components of the HPA stress system and its responses, which may partially form the basis for sex disparities in disease development. Despite this, many studies use male subjects exclusively, while fewer reports involve females or provide direct sex comparisons. The purpose of this article is to present sex comparisons in the functional and molecular aspects of the HPA axis, through various phases of activity, including basal, acute stress, and chronic stress conditions. The HPA axis in females initiates more rapidly and produces a greater output of stress hormones. This review focuses on the interactions between the gonadal hormone system and the HPA axis as the key mediators of these sex differences, whereby androgens increase and estrogens decrease HPA activity in adulthood. In addition to the effects of gonadal hormones on the adult response, morphological impacts of hormone exposure during development are also involved in mediating sex differences. Additional systems impinging on the HPA axis that contribute to sex differences include the monoamine neurotransmitters norepinephrine and serotonin. Diverse signals originating from the brain and periphery are integrated to determine the level of HPA axis activity, and these signals are, in many cases, sex-specific.

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Mad men, women and steroid cocktails: a review of the impact of sex and other factors on anabolic androgenic steroids effects on affective behaviors

Onakomaiya

Henderson

2016

Psychopharmacology

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Rationale For several decades, elite athletes and a growing number of recreational consumers have used anabolic androgenic steroids (AAS) as performance enhancing drugs. Despite mounting evidence that illicit use of these synthetic steroids has detrimental effects on affective states, information available on sex-specific actions of these drugs is lacking. Objectives The focus of this review is to assess information to date on the importance of sex and its interaction with other environmental factors on affective behaviors, with an emphasis on data derived from non-human studies. Methods The PubMed database was searched for relevant studies in both sexes. Results Studies examining AAS use in females are limited, reflecting the lower prevalence of use in this sex. Data, however, indicate significant sex-specific differences in AAS effects on anxiety-like and aggressive behaviors, interactions with other drugs of abuse, and the interplay of AAS with other environmental factors such as diet and exercise. Conclusions Current methods for assessing AAS use have limitations that suggest biases of both under- and over-reporting, which may be amplified for females who are poorly represented in self-report studies of human subjects and are rarely used in animal studies. Data from animal literature suggest that there are significant sex-specific differences in the impact of AAS on aggression, anxiety, and concomitant use of other abused substances. These results have relevance for human females who take these drugs as performance enhancing substances and for transgender XX individuals who may illicitly self-administer AAS as they transition to a male gender identity.

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Male rats with the testicular feminization mutation of the androgen receptor display elevated anxiety-related behavior and corticosterone response to mild stress

Cited by 58 publications

References 78 publications

Assessing gonadal hormone contributions to affective psychopathologies across humans and animal models

Assessing gonadal hormone contributions to affective psychopathologies across humans and animal models

Sex Differences in the HPA Axis

Mad men, women and steroid cocktails: a review of the impact of sex and other factors on anabolic androgenic steroids effects on affective behaviors

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