Malignancy arising in cystic ovarian teratomas.

Stamp, Gordon; McConnell, E. M.

doi:10.1111/j.1471-0528.1983.tb09289.x

Cited by 107 publications

(70 citation statements)

References 15 publications

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“…Puede ser clasificado como primario o secundario (metastásico). El tipo primario se asocia con algunos tumores de ovario como el teratoma quístico maduro, tumor de Brenner, cistoadenoma mucinoso y con focos de endometriosis ovárica (2,4,5). La gran mayoría corresponden a carcinomas escamosos originados de un teratoma quístico maduro que ha presentado transformación maligna de la estirpe escamosa (3), proceso que es reportado en la literatura con una frecuencia de aproximadamente 2% (6).…”

Section: Discussionunclassified

“…Se puede clasificar como primario o secundario, siendo el primer grupo el más frecuente, en particular, aquellos derivados de un teratoma quístico maduro (2). La frecuencia de transformación maligna en este tipo de tumores ocurre en alrededor del 2% de los casos, correspondiendo la estirpe escamosa la lí-nea germinal más frecuentemente afectada (3).…”

Section: Introductionunclassified

See 1 more Smart Citation

Carcinoma Escamoso Ovárico Bilateral

Z¹,

P²,

F³

et al. 2006

Rev. chil. obstet. ginecol.

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RESUMENSe presenta un caso clínico de carcinoma escamoso de ovario bilateral, derivado de un teratoma quístico maduro de ovario derecho, en paciente de 41 años, que ingresó de urgencia por dolor y aumento de volumen pélvico. Se efectuó histerectomía total más salpingooforectomía bilateral, omentectomía infracólica, apendicectomía, citología líquido peritoneal y resección parcial de tumor en fondo de saco de Douglas que comprometía el recto. Fue derivada a centro oncológico, se efectuó nueva cirugía y quimioterapia complementaria. Fallece a los 7 meses de su cirugía inicial. PALABRAS CLAVES: Carcinoma escamoso de ovario, teratoma quístico maduro SUMMARYA clinical case of bilateral ovarian squamous cell carcinoma, derived from a mature cystic teratoma of righ ovary in a patient of 41 years old that entered to the gynecoloy service by pain and pelvic mass. Total hysterectomy and bilateral salpingo-oophorectomy, infracolic omentectomy, appendectomy, peritoneal fluid cytology was practiced and partial extraction of the tumour that invades rectum. Patient continued control and a new surgery plus chemotherapy was carried out, dying to the seven months of inicial surgery.KEY WORDS: Squamous cell carcinoma of the ovary, mature cystic teratoma Casos Clínicos INTRODUCCIÓNEl carcinoma ovárico de estirpe escamosa o espinocelular es poco frecuente (1). Se puede clasificar como primario o secundario, siendo el primer grupo el más frecuente, en particular, aquellos derivados de un teratoma quístico maduro (2). La frecuencia de transformación maligna en este tipo de tumores ocurre en alrededor del 2% de los casos, correspondiendo la estirpe escamosa la lí-nea germinal más frecuentemente afectada (3). Se presenta el caso clínico de una paciente que desarrolló un carcinoma escamoso bilateral de ovario, originado en un teratoma quístico maduro. CASO CLÍNICO

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Section: Discussionunclassified

Section: Introductionunclassified

Carcinoma Escamoso Ovárico Bilateral

Z¹,

P²,

F³

et al. 2006

Rev. chil. obstet. ginecol.

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“…A malignant tumor that arises in a pre-existing mature teratoma is called teratoma with malignant transformation (3). Malignant transformation occurs in 1-3% of all mature teratomas (4). Squamous cell carcinoma is the most common form of transformation (5).…”

Section: Introductionmentioning

confidence: 99%

Carcinoid tumor arising in a mature cystic teratoma: A case report

et al. 2015

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Abstract. Mature cystic teratomas are common benign tumors of the ovary. The most common form of malignant transformation is squamous cell carcinoma, however, malignant transformation is rarely observed and cases are usually asymptomatic. Carcinoid tumors are rare tumors of the neuroendocrine system. A number of the carcinoids result in clinical syndromes due to the secretion of vasoactive substances produced by the tumor. A 75-year-old woman suffering from groin pain was admitted to the Faculty of Medicine at Bezmialem Vakıf University (Istanbul, Turkey). An adnexal mass was detected during the physical examination. Magnetic resonance imaging scans exhibited an 8x7-cm mass in the right ovary. Surgical excision of the mass was performed and histopathological examination revealed a mature cystic teratoma with three germ layers. An area consisting of nests and trabeculae was evident in the cyst wall. The pathological diagnosis was of an insular and trabecular variant of carcinoid tumor arising in a mature cystic teratoma. The patient did not present with carcinoid syndrome, and no recurrence was observed after 11 months of follow-up examinations.

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“…In contrast, the malignant transformation of mature cystic teratoma, usually present as a squamous cell carcinoma, occurs only in 1-2% of the cases (3)(4)(5)(6). It is well known that clinically advanced cases with squamous cell carcinoma arising from mature cystic teratoma have poor prognosis partly because of its poor response to chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Malignant transformation of mature cystic teratoma of the ovary including three cases occurring during follow-up period

Yamaguchi

Mandai²,

Fukuhara³

et al. 2008

Oncol Rep

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Abstract. The aim of this study was to seek for factors which lead to the early diagnosis of malignant transformation from mature cystic teratoma. Fourteen patients with malignant transformation from mature cystic teratoma of the ovary were analyzed retrospectively for precise clinicopathology and prognosis. The results demonstrated that although all the patients with stage Ia disease were disease-free, only 2 out of 7 patients were stage Ic to IV and disease-free in the follow-up period. Pre-operative imaging correctly diagnosed tumors as malignant in all stage Ic to IV cases, but only in 2 out of 4 stage Ia cases with magnetic resource and none of the 2 cases with computed tomography, respectively. In malignant cases, elevation of the serum SCC and CEA was observed in 90.9 and 88.9%, respectively. On the other hand, in benign cases, a false positive elevation of the serum SCC and CEA was observed in 23.5 and 14.3%, which turned out to be normal in 40 and 52.9% cases in the repeated study, respectively. In conclusion neither imaging analysis nor tumor markers including SCC and CEA accurately diagnose malignant transformation of mature cystic teratoma in its early stage, suggesting that a combination of diagnostic means is important. In the followup cases, repeated measurement of serum markers proved useful in ruling out false positive cases.

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Malignancy arising in cystic ovarian teratomas.

Cited by 107 publications

References 15 publications

Carcinoma Escamoso Ovárico Bilateral

Carcinoma Escamoso Ovárico Bilateral

Carcinoid tumor arising in a mature cystic teratoma: A case report

Malignant transformation of mature cystic teratoma of the ovary including three cases occurring during follow-up period

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