Malignant Hyperthermia: A Review

Incidence of malignant hyperthermia reactions in 2,214 patients undergoing muscle biopsy

“…A small biopsy was also frozen in liquid carbon dioxide and then analyzed as described previously. 3 At the completion of surgery, all anaesthetic drugs were discontinued and 100% oxygen was administered. Upon arrival in the recovery room, axillary and nasal temperature sites, heart rate, respiratory rate and blood pressure were monitored for at least four to six hours.…”

Malignant hyperthermia

“…An electronic axillary temperature probe is installed before induction and a nasal temperature probe is inserted immediately after induction. 3'6-s'11, 13,24,25 Before commencement of anaesthesia, a blood pressure cuff and oximeter are attached to the patient and blood for muscle enzymes, electrolytes and venous blood gases are taken. Venous blood gases are more valuable than arterial blood gases, because blood coming from muscle alters first, rather than blood coming from the lungs.…”

Effects of midazolam on directly stimulated muscle biopsies from control and malignant hyperthermia positive patients

“…7 We wished to determine if any interactions exist between midazolam and halothane in muscle biopsies from control patients. There were no detectable interactions of these two agents on our muscle preparation.…”