Malignant peripheral primitive neuroectodermal tumor‐peripheral neuroepithelioma of the head and neck: A clinicopathologic study of five cases and review of the literature

Nikitakis, Nikolaos G.; Salama, Andrew; O’Malley, Bert W.; Ord, Robert A.; Papadimitriou, John C.

doi:10.1002/hed.10260

Cited by 45 publications

(49 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In general, the gender distribution of patients with PNET varies among different studies. 1,3,6 We found that women slightly predominate, as distinct from the previously maxillary PNET cases reported by Shah et al in 2014 (male/female ratio of 9:10) ( Table 1). 1 As in our case, there was either as a soft tissue mass or swelling in the most of the reported cases of PNETs of the maxilla in Table 1.…”

Section: Discussionsupporting

confidence: 63%

See 1 more Smart Citation

Imaging Features of Primitive Neuroectodermal Tumor in the Maxilla: A Case Report and Literature Review

Bozdemir¹,

Fındık²,

Bilgir³

et al. 2016

Turkiye Klinikleri J Dental Sci Cases

View full text Add to dashboard Cite

106rimitive neuroectodermal tumor (PNET) is a term used to describe a group of highly rare and malignant neoplasms composed of undifferentiated round cell tumors of neuroectodermal origin with variable cell differentiation. PNET generally occurs in the central nervous system (CNS); peripheral PNET occurring outside the CNS has also been reported. Peripheral PNET is commonly related to Ewing's sarcoma (ES). However, it exhibits a more aggressive clinical behavior than ES, with extremely rapid metastasis. PNET has a poor prognosis and is commonly seen in children and young adults.1 Because this tumor presents aggressive biological behavior and tends toward loco-regional and systemic metastases, it is a tumor with an extremely poor survival rate.2 The incidence of head and neck PNET Imaging Features of Primitive Neuroectodermal Tumor in the Maxilla: A Case Report and Literature Review A AB BS S T TR RA AC CT T Primitive neuroectodermal tumor (PNET) is a term used to describe a group of highly malignant neoplasms composed of undifferentiated round cell tumors of neuroectodermal origin with variable cell differentiation. PNET generally occurs in the central nervous system (CNS), but peripheral PNET occurring outside the CNS has also been reported. The most common location of PNET in head and neck region is the orbit, followed by the neck and the parotid gland. PNET of the maxilla is rare. The aims of this report are to present the case of a 41-year-old female diagnosed with PNET tumor of the maxilla after detailed clinical, radiological, and histopathological examinations and to review the previously reported cases of PNET of the maxilla in the literature.K Ke ey y W Wo or rd ds s: : Neuroectodermal tumors, primitive, peripheral; maxilla; diagnosis; cone-beam computed tomography Ö ÖZ ZE ET T Primitif nöroektodermal tümör (PNET), nöroektodermal kökenli farklılaşmamış yuvarlak hücreli tümörlerden oluşan son derece malign tümörlerin bir grubunu tanımlamak için kullanılan bir terimdir. PNET genellikle santral sinir sisteminde meydana gelir fakat santral sinir sistemi dışında ortaya çıkan periferal PNET olguları da rapor edilmiştir. Baş-boyun bölgesinde en fazla gözde görülür. Gözden sonra en sık boyun ve parotis bezinde görülür. Maksilladaki PNET nadirdir. Bu raporun amacı detaylı klinik, radyolojik ve histopatolojik incelemeden sonra maksillada PNET tanısı koyulan 41 yaşında kadın hastayı sunmak ve literatürde daha önce rapor edilen maksilladaki PNET vakalarını incelemektir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Nöroektodermal tümörler, primitif, periferik; maksilla; tanı; konik ışınlı bilgisayarlı tomografi T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i J J D De en nt ta al l S Sc ci i C Ca as se es s 2 20 01 16 6; ;2 2( (3 3) ): :1 10 06 6--1 12 2

show abstract

Section: Discussionsupporting

confidence: 63%

“…3 The most common location of PNET in the head and neck region is the orbit; followed by the neck and the parotid gland. 4 However, peripheral PNET has also been reported in the temporal region, paranasal sinuses, skull and masseter muscle in the head and neck region.…”

mentioning

confidence: 99%

Imaging Features of Primitive Neuroectodermal Tumor in the Maxilla: A Case Report and Literature Review

Bozdemir¹,

Fındık²,

Bilgir³

et al. 2016

Turkiye Klinikleri J Dental Sci Cases

View full text Add to dashboard Cite

show abstract

“…3,6 It is thought that the NEDT comes from the neoplastic transformation of primitive neuroepithelial cells. The fact that such cells may remain anywhere in the nervous system may explain the diverse origins of this tumor.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 The peripheral NEDT on the head and neck is extremely rare, and in a recent literature review we did not see any publication of such tumor involving the temporal bone and the facial nerve canal. 3 Our goal with the present paper is to report on a patient who presented peripheral facial paralysis as initial manifestation of the peripheral NEDT involving the temporal bone. Following that, we ordered a brain and skull base MRI study; the patient returned after three weeks with a normal brain MRI and additional complaints (back pain and lower limb paresis), being admitted to the Neurosurgery department.…”

Section: Introductionmentioning

confidence: 99%

Tumor neuroectodérmico primitivo periférico: caso raro de paralisia facial periférica

Tiago

Pio

Silva

et al. 2007

Rev. Bras. Otorrinolaringol.

View full text Add to dashboard Cite

“…a Pituitary hormones and/or pituitary transcription factors, but may include or peptides and hormones (ADH, oxytocin). Based on data aggregate in part from Bahrami et al, 36 Bell et al, 51 Bishop et al, 74 Bourne et al, 143 Chapman-Fredricks et al, 88 Folpe et al, 151 Hafezi et al, 150 Hicks et al, 30 Nikitakis et al, 166 Thompson et al, 7 Thompson et al, 124 Thompson et al, 159 and Wooff et al 57 …”

Section: Melanomamentioning

confidence: 99%

Small round blue cell tumors of the sinonasal tract: a differential diagnosis approach

Thompson

2017

Modern Pathology

View full text Add to dashboard Cite

One of the most challenging diagnostic categories within tumors of the sinonasal tract is the small round blue cell tumors. Biopsies are usually small and limited, resulting in considerable diagnostic difficulty for practicing surgical pathologists. These tumors share several overlapping histologic and immunophenotypic findings while also showing considerable variation within and between cases. Specific tumor site of origin, imaging findings, and clinical findings must be combined with the histology and pertinent ancillary studies if the correct diagnosis is to be reached. Discrimination between neoplasms is critical as there are significant differences in therapy and overall outcome. It is important to have a well developed differential diagnosis for this category of tumors, where each of the diagnoses is considered, evaluated, and either confirmed or excluded from further consideration. In an undifferentiated tumor, showing a small round blue cell morphology, using the mnemonic 'MR SLEEP' helps to highlight tumors to consider: melanoma, mesenchymal chondrosarcoma, rhabdomyosarcoma, sinonasal undifferentiated carcinoma, squamous cell carcinoma (including NUT carcinoma), small cell osteosarcoma, lymphoma, esthesioneuroblastoma (olfactory neuroblastoma), Ewing sarcoma/primitive neuroectodermal tumor, pituitary adenoma, and plasmacytoma. A panel of pertinent immunohistochemistry studies, histochemistries and/or molecular tests should aid in reaching a diagnosis, especially when taking the pattern and intensity of reactions into consideration.

show abstract

Malignant peripheral primitive neuroectodermal tumor‐peripheral neuroepithelioma of the head and neck: A clinicopathologic study of five cases and review of the literature

Abstract: Malignant pPNET-peripheral neuroepithelioma should be included in the differential diagnosis of small, round, blue cell tumors of head and neck. A combination of multiple diagnostic modalities is essential for correct diagnosis, and multimodality treatment offers the best outcome.

Cited by 45 publications

References 38 publications

Imaging Features of Primitive Neuroectodermal Tumor in the Maxilla: A Case Report and Literature Review

Imaging Features of Primitive Neuroectodermal Tumor in the Maxilla: A Case Report and Literature Review

Tumor neuroectodérmico primitivo periférico: caso raro de paralisia facial periférica

Small round blue cell tumors of the sinonasal tract: a differential diagnosis approach

Contact Info

Product

Resources

About