Malignant peritoneal mesothelioma as a rare cause of ascites: a case report

Ahmed, Iftikhar; Koulaouzidis, Anastasios; Iqbal, Javaid; Tan, Wong C

doi:10.1186/1752-1947-2-121

Cited by 16 publications

(14 citation statements)

References 3 publications

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“…However, CT did not show multiple nodules in the omentum and serosa of the abdominal organs located in the cranial and middle abdomen. “Omental cake” is a specific CT finding indicative of omental infiltration [14, 15]. Our results indicate the difficulty in CT visualization of the serosal lesions due to poor image quality associated with the respiratory motion of the examined animal.…”

Section: Discussionmentioning

confidence: 85%

“…In addition, our technique, in which the biopsy needle was percutaneously inserted into the abdomen through a part different from the trocar, is not a simple method for intra-abdominal introduction of a biopsy needle. Centesis associated with needle and port sites can facilitate tumor dissemination [14]. This can be minimized using a one-port assisted core-needle biopsy technique, in which a biopsy forceps is introduced into the channel of the operating endoscope [29].…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic efficacy of imaging and biopsy methods for peritoneal mesothelioma in a calf

et al. 2019

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BackgroundPeritoneal mesothelioma is a rare abdominal disease; that occasionally occurs congenitally in younger calves. Cytologic examination of peritoneal effusion (PE) was utilized to diagnose this disease, and was not diagnostic. Diagnostic accuracy has been elevated by recent use of ultrasonography (US), despite most diagnoses have been obtained post-mortem in slaughter houses or during clinical necropsy. In humans, ante-mortem diagnosis is highly associated with clinical use of computed tomography (CT) and laparoscopy together with imaging-assisted biopsy. The present report evaluates the diagnostic applicability of CT and laparoscopy as well as US via the practical application of these imaging modalities in an affected calf, and compares the cytologic and histologic findings among in PE, and specimens obtained from fine-needle aspiration and core-needle biopsy. In addition, the present results were reviewed in comparison with those of previous bovine and human reports.Case presentationA 58-day-old male Japanese black calf presented first with scrotal swelling, followed by progressive abdominal distention. Abnormalities of the case included: 1) accumulation of anechoic PE inside the swollen scrotum and abdomen; 2) formation of multiple echogenic nodules within the peritoneal membrane based on US images; 3) presence of hyper-dense spots (suspected calcification) along the margins of the nodules; 4) anatomic connections between intra-abdominal nodular lesions and the swollen tunica vaginalis via the inguinal region based on CT images; 5) serosanguineous-colored and less-turbid characteristics of PE; and 6) formation of multiple nodules over all of the serosa of the rumen as well as the peritoneal wall based on laparoscopic views. Fine-needle aspiration and core-needle biopsy were successfully performed under US and laparoscopic observations, respectively. Histology findings of the core-needle biopsy specimen appeared more indicative (characterization of tubular structures comprised of cubical or columnar abnormal mesothelial cell linings) diagnostically of peritoneal mesothelioma than did findings of the fine-needle aspiration specimen.ConclusionsTo the best of our knowledge, this report is the first description of clinical applications of CT and laparoscopy to diagnose peritoneal mesothelioma in a calf. Laparoscopy enhanced the diagnostic accuracy due to clear gross visualization of the intra-abdominal abnormalities and applicability to imaging-guided core-needle biopsy.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Diagnostic efficacy of imaging and biopsy methods for peritoneal mesothelioma in a calf

et al. 2019

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“…Malignant peritoneal mesothelioma (MPM) is a rare disease that typically demonstrates a poor prognosis, with an average survival time of 6–12 months (1). The incidence in the United States is 200–400 novel cases annually (2).…”

Section: Introductionmentioning

confidence: 99%

The diagnostic utility of PAX8 immunostaining of malignant peritoneal mesothelioma presenting as serous ovarian carcinoma: A single-center report of two cases

et al. 2016

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Malignant peritoneal mesotheliomas (MPMs) are rare and progressive tumors, which may present similarly to primary peritoneal carcinoma or ovarian carcinoma (OC). The current study reports two cases of MPM that initially presented with the features of OC, for which paired box 8 (PAX8) immunostaining was found to be useful for diagnosis. The two patients were women, aged 58 and 56 years, respectively. The primary presenting symptoms and clinical findings included prolonged abdominal pain, abdominal swelling and cough. The two cases were initially diagnosed as OC and were treated with primary debulking surgery. The patient in case 1 had no history of asbestos exposure, while the patient in case 2 did. Final diagnoses were determined based on histological and immunohistochemical results, which included negative PAX8 immunostaining, and which were consistent with MPM. The present cases demonstrated that PAX8 negativity may be a useful diagnostic biomarker for differentiating MPM from OC.

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“…Malignant peritoneal mesothelioma is an uncommon disease and has a very poor prognosis with an average survival time between 5 and 12 months [ 1 ]. Inadequate and delayed treatment is the main reason for this short survival time.…”

Section: Introductionmentioning

confidence: 99%

Malignant Peritoneal Mesothelioma: Clinicopathological Characteristics of Two Cases

Algın

Yaylak

Bayhan

et al. 2014

Case Reports in Surgery

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Introduction. Peritoneal mesothelioma is a rare tumor, presenting difficulties in diagnosis and treatment. Peritoneum is the second most common area of the mesothelioma after pleura, and even synchronous pleural and peritoneal mesotheliomas are observed in 30–45% of all cases. The diagnosis may be difficult due to lack of specific symptoms and clinical findings. In addition, a delay in the diagnosis is not rare especially in the absence of previous asbestos exposure. Here we report two cases of malignant peritoneal mesotheliomas. The diagnostic and therapeutic approaches for these rare neoplasms are discussed. Case Presentation. The cases were two men (one aged 54 years old and the other 40 years old). Prolonged abdominal pain and swelling were the primary presentation symptoms and findings. The mesotheliomas were developed in the right upper quadrant of abdomen in both of the cases. Both cases were treated with surgical resection. Final diagnosis were possible with histological and immunohistochemical documentation of tumor characteristics, which were consistent with dictating a mesothelial origin. No history of asbestos exposure was reported. Conclusion. Peritoneal mesotheliomas are rare clinical entities. However, patients with prolonged abdominal pain and abdominal masses should be considered to have atypical pathologies such as peritoneal mesotheliomas.

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Malignant peritoneal mesothelioma as a rare cause of ascites: a case report

Cited by 16 publications

References 3 publications

Diagnostic efficacy of imaging and biopsy methods for peritoneal mesothelioma in a calf

Diagnostic efficacy of imaging and biopsy methods for peritoneal mesothelioma in a calf

The diagnostic utility of PAX8 immunostaining of malignant peritoneal mesothelioma presenting as serous ovarian carcinoma: A single-center report of two cases

Malignant Peritoneal Mesothelioma: Clinicopathological Characteristics of Two Cases

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