Malignant phyllodes tumor of the breast: review of the literature and case report of stromal overgrowth

Guerrero, Marlon A.; Ballard, Billy R.; Grau, Ana M.

doi:10.1016/s0960-7404(03)00005-7

Cited by 126 publications

(160 citation statements)

References 43 publications

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“…Breast tumor is still a major health burden for Chinese women, especially in urban areas (1,2), among them, phyllodes tumors of the breast (PTB) is a clinically rare type of breast tumor, accounting for 2.0-3.0% of breast fibroepithelial tumors and only 0.3-1.0% of all breast tumors (3)(4)(5). PTB has a propensity to occur in females Original Article Diagnostic performance of core needle biopsy in identifying breast phyllodes tumors 35-55 years old (6), exhibits diverse biological behaviors, and has a high rate of local recurrence (5,7,8).…”

Section: Introductionmentioning

confidence: 99%

“…PTB has a propensity to occur in females Original Article Diagnostic performance of core needle biopsy in identifying breast phyllodes tumors 35-55 years old (6), exhibits diverse biological behaviors, and has a high rate of local recurrence (5,7,8).…”

Section: Introductionmentioning

confidence: 99%

“…There are tremendous controversies regarding the nomenclature, classification (5)(6)(7)(8)(9)(10), and biological traits of PTB. There are over 60 terms for this type of tumor in the literature, including phyllodes tumor, pseudosarcoma adenoma, mucus gland tumor, breast mixed tumor, and pseudo-sarcoma.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic performance of core needle biopsy in identifying breast phyllodes tumors

Zhou¹,

Wang²,

Sun³

et al. 2016

J. Thorac. Dis.

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Background: A retrospective analysis of diagnoses was performed in patients with phyllodes tumors of the breast (PTB) who received preoperative core needle biopsy (CNB) and had breast surgery at Fudan University Shanghai Cancer Center from January 1, 2002 to April 1, 2013. The resulting data allowed us to compare the accordance between CNB and excision diagnoses of PTB patients and evaluate the accuracy of CNB in preoperative diagnosis. Methods:Data from 128 patients with PTB who had undergone preoperative CNB and breast surgery were retrospectively analyzed. We reviewed the medical history, clinical follow-up data, and CNB diagnostic data. A diagnostic test was used to evaluate the sensitivity and specificity of CNB in diagnosing benign, borderline, and malignant phyllodes tumors.Results: The accuracy of CNB for diagnosing PTB was 13.3% (17/128). Of the remaining patients, 98(75.5% of the PTB patients) were diagnosed with fibroadenoma or fibroepithelial lesions. The sensitivity of CNB at diagnosing benign, borderline, and malignant phyllodes tumors were 4.9% (2/41), 4.2% (3/71), and 25.0% (4/16), respectively, whereas the corresponding specificity were 92.0%, 98.2%, and 100%, respectively. Some clinical features, such as large tumor size, rapid growth, or surgical history of fibroadenomas, were indicative of an increased possibility of PTB.Conclusions: CNB provides a pathological basis for the preoperative diagnosis of PTB, but it has a poor accuracy and offers limited guidance for surgical decisions. Considering CNB along with multiple histologic features may improve the ability to accurately diagnose PTB. An integrated assessment using CNBs in combination with clinical data and imaging features is suggested as a reliable strategy to assist PTB diagnosis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diagnostic performance of core needle biopsy in identifying breast phyllodes tumors

Zhou¹,

Wang²,

Sun³

et al. 2016

J. Thorac. Dis.

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“…Fibroepithelial tumors of the breast are essentially comprised of fibroadenomas (FAs) and phyllodes tumors (PTs) (1). FAs are the most common type, constituting a benign entity formed by stromal overgrowth with an epithelial component from the terminal duct.…”

Section: Introductionmentioning

confidence: 99%

Stromal and epithelial cells react differentially to c-kit in fibroepithelial tumors of the breast

et al. 2008

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“…Osteosarcomatous differentiation of a malignant phyllodes tumor of the breast is extremely rare. There are no predisposing factors and the etiology of a phyllodes tumor is unknown (5). Although there is no proven benefit of either radiotherapy or chemotherapy, radiotherapy can be used (6).…”

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confidence: 99%

Malignant Phyllodes Tumor of the Breast With Osteosarcomatous Differentiation

Küçük¹,

Bayol²,

Etıt³

et al. 2013

J Breasth Health

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Malignant phyllodes tumor of the breast: review of the literature and case report of stromal overgrowth

Cited by 126 publications

References 43 publications

Diagnostic performance of core needle biopsy in identifying breast phyllodes tumors

Diagnostic performance of core needle biopsy in identifying breast phyllodes tumors

Stromal and epithelial cells react differentially to c-kit in fibroepithelial tumors of the breast

Malignant Phyllodes Tumor of the Breast With Osteosarcomatous Differentiation

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