Malignant Squamous Cell Thymoma in a Horse

Whiteley, Laurence O.; Leininger, Joel R.; Wolf, Charles; Ames, Trevor R.

doi:10.1177/030098588602300514

Cited by 23 publications

(9 citation statements)

References 6 publications

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“…Thymoma, a neoplasm of thymic epithelial cells, is reported uncommonly in a variety of domesticated animals [2–5] and rarely in the horse [6–8]. Although thymomas appear benign histologically, clinically they are characterized as benign or malignant, according to their invasive behaviour.…”

Section: Case Reportmentioning

confidence: 99%

“…Thymic epithelial tumor is rarely reported in horses [6–8] and most other animal species. Goats are the exception with a significantly higher reported incidence [2, 5, 13].…”

Section: Case Reportmentioning

confidence: 99%

“…Goats are the exception with a significantly higher reported incidence [2, 5, 13]. Of the limited number of reported equine thymic epithelial neoplasms, two cases in Japan were behaviorally benign with no metastases, [7] and only two cases of thymic carcinoma were reported in horses with metastases to lung, thyroid, rib, kidney and lymph nodes [6, 8]. …”

Section: Case Reportmentioning

confidence: 99%

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Thymic Epithelial Tumor with Heart Metastasis in a Horse

Shahriar

Moore

2010

Veterinary Medicine International

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Thymic malignancy is rare in horses. Thymic epithelial tumor was diagnosed in an 18-year-old mare with invasion and metastasis to the pericardium and heart. At necropsy, the cranial thoracic cavity was obliterated by a large mass located in the thymic region and the right atrium was also expanded and effaced by a similar mass. Histologically, the neoplasm was composed of sheets of spindle cells with intraparenchymal Hassall's corpuscles and formation of pseudorosettes around blood vessels compatible with type A thymic epithelial tumor according to World Health Organization classification. The neoplastic cells were diffusely immunoreactive for cytokeratin and negative for vimentin, S100, neuron specific enolase, glial fibrillar acidic protein, chromogranin A, synaptophysin, CD3 and CD79a markers. To the authors' knowledge, cardiac invasion and distinct histological pattern of pseudorosette formation have not been described in equine thymic epithelial tumors previously.

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Section: Case Reportmentioning

confidence: 99%

“…Thymic epithelial tumor is rarely reported in horses [6–8] and most other animal species. Goats are the exception with a significantly higher reported incidence [2, 5, 13].…”

Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

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Thymic Epithelial Tumor with Heart Metastasis in a Horse

Shahriar

Moore

2010

Veterinary Medicine International

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“…An adenocarcinoma variant of thymic carcinoma, however, was reported in a dog [1], and feline [6] and equine [21] squamous cell carcinomas of the thymus were characterized, respectively, by keratinization and structures resembling Hassall's corpuscles. Human thymic carcinomas with squamous differentiation may show keratinization [18] or glandular differentiation [12].…”

mentioning

confidence: 99%

“…In the thymus of a calf, the epithelialreticular cells frequently showed cytoplasmic staining for thymosin. Thymic carcinoma is rare in domestic animals, but has been reported in dogs [1,2], cats [3,6], a horse [21], and a cow [13]. Although squamous cell carcinoma or lymphoepithelioma-like carcinoma predominates in human thymic carcinomas, mucoepidermoid carcinoma [18], adenosquamous carcinoma [17] and adenocarcinoma [4] have been observed.…”

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confidence: 99%

Thymic Carcinoma of the Thymic Hormone Secretory Type in a Cow.

et al. 1999

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ABSTRACT. An 8-year-old Holstein cow had tumor nodules and enlarged lymph nodes in the mediastinum, and metastatic tumor masses in the pelvic cavity. The neoplastic cells were characterized by squamous features and intracytoplasmic vacuoles carrying microvilli, some of which contained periodic acid Schiff-positive globular cores, but tubular structures or goblet cells were absent. Many neoplastic cells stained positively for keratin, and occasional cells were positive for thymosin. The presence of secretory granules in the cytoplasm was confirmed by electron microscopy. This neoplasm was considered to be of thymic hormone-secreting epithelial cell origin.-KEY WORDS: bovine, thymic carcinoma, thymosin.

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