Malondialdehyde Levels in Oral Sub Mucous Fibrosis: A Clinicopathological and Biochemical Study

Shetty, Shishir Ram; Babu, Subhas; Kumari, Suchetha; Rao, Vaman C.; Vijay, Rahul; Karikal, Arvind

doi:10.4103/1947-2714.93887

Cited by 22 publications

(21 citation statements)

References 11 publications

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“…in 2012 in their study establish that there is significantly augmented plasma levels of MDA in patients with oral submucous fibrosis when compared to that of controls group. [1623] In our observations, there is elevation in serum MDA levels in patients with oral submucous fibrosis when compared with controls and MDA level was increased when the clinical stage increases.…”

Section: Discussionsupporting

confidence: 52%

Oral submucous fibrosis: A quantitative assessment of serum malondialdehyde, superoxide dismutase and correlation with clinical staging

Bale¹,

Kattappagari

Vidya

et al. 2017

J Oral Maxillofac Pathol

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Background:Oral submucous fibrosis (OSMF) is a progressive disorder affecting the oral mucosa. OSMF predominantly seen in South-east Asian countries. There are some biochemicals parameters which are modify in oral submucous fibrosis; this alteration can be used as a tool for diseases progress and avert malignant transformation.Aims and Objectives:The aim of this study is to evaluate the serum malondialdehyde (malondialdehyde [MDA]), and Superoxide dismutase (SOD) in oral sub mucous fibrosis cases and compare clinical stages.Materials and Methods:Thirty cases of clinical and histopathological established oral submucous fibrosis and thirty cases of nonsymptomatic features of oral submucous fibrosis preferred as controls. Venous blood was collected and separation of serum for estimation of MDA and SOD levels was done using an ultraviolet spectrophotometer.Statistical Analysis:Data were analyzed using SPSS software using Student's t-test and Kruskal–Wallis ANOVA test.Results:Serum MDA levels were elevated when clinical staging increases, where as SOD levels were decreased when clinical stage increases when compared with control cases and it showed stastically significant.Conclusion:Estimation of serum MDA and SOD in patients with OSMF, we can assess the degree of oxidative damage of the disease. This can be used as an early diagnostic tool for preventing malignant transformation of oral submucous fibrosis.

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Section: Discussionsupporting

confidence: 52%

Oral submucous fibrosis: A quantitative assessment of serum malondialdehyde, superoxide dismutase and correlation with clinical staging

Bale¹,

Kattappagari

Vidya

et al. 2017

J Oral Maxillofac Pathol

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“…There are numerous biological pathways involved in the above processes and, it is likely that the normal regulatory mechanisms are either down regulated or up regulated at different stages of the disease. [20][21][22] Though consumption of areca nut preparation is common in Nepalgunj but OSMF is not seen in all consumers of these preparations in our clinical experience. A good case control study is required to establish it.…”

Section: Discussionmentioning

confidence: 99%

Clinical profile and oral sub mucous fibrosis

Bhatta

Pyakurel

2017

Nepalese J ENT Head Neck Surg

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Objectives: Oral submucous fibrosis (OSMF) is an insidious precancerous disease mostly seen in the Southeast Asia. This paper aims to study on clinical profile of patients with OSMFMaterial and Methods: This cross sectional study was done in department of ENT and HNS, Nepalgunj Medical College and Teaching Hospital. In outpatient department patients with OSMF were ask to fill up a questionnaire that included identification of patient, occupation, their symptoms and habit of taking betel quid or paan, gutkha, etc. Oral cavity was examined and lesion along with its extent and severity was noted. Intra lesional steroid and antioxidant and physiotherapy were main stay of treatment.Results: There were total 136 patients (98 male and 38 female) from 15th Dec 2013 to 15th Jan 2015. Age of patient ranged from 16 years to 53 years and average being 25.6years. Most common preparation taken was gutkha 131(96.3%) followed by betel nut, betel quid etc. Only 24(17.6%) were taking these preparations for less than 1 year. Common presenting complaints were difficulty in opening mouth followed by burning sensation and dryness of mouth. Clinically, the extent of fibrous band was found to be more commonly involving soft palate, pillars and buccal mucosa. Isolated involvement of different region of oropharynx or oral cavity was less common. Correlation of grade of trismus and average duration of taking these different preparations was highly significant. (p=0.008)Conclusions: Oral submucous fibrosis is commonly associated with intake of gutkha having dose dependent relationship with trismus. Further studies are required why only a small fraction of those using betel quid develop the disease.

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“…Areca nut has a high copper content; accordingly, the role of copper in the pathogenesis of oral submucous fibrosis has been investigated by a wide array of studies . Lysyl oxidase is a copper‐activated enzyme critical for collagen cross‐linking and organization of extracellular matrix …”

Section: Pathogenesismentioning

confidence: 99%

Oral submucous fibrosis: A global challenge. Rising incidence, risk factors, management, and research priorities

Ray

Chatterjee

Chaudhuri

2019

Periodontology 2000

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Oral submucous fibrosis is a potentially malignant disorder of the oral cavity, with a high rate of malignant transformation. It is very common among habitual areca nut chewers. The pathogenesis of oral submucous fibrosis is not well established, but it is believed to be a disease of multifactorial origin, including areca nut chewing, ingestion of chilies, genetic factors, immunologic processes and nutritional deficiencies. Genetically susceptible individuals when exposed to areca nut chewing develop this disease over a variable period of time. Oral submucous fibrosis is considered to be a disease of collagen metabolism. Several genetic factors are reported but there is no consensus about the exact mechanism of disease initiation. Variations in histopathological presentation are noted among oral submucous fibrosis patients with habitual areca nut chewing in different forms and other additive agents, eg betel quid, pan masala and gutkha, together with a variety of tobacco habits. The role of epigenetic modifications, such as miRNA regulation, and DNA methylation is also being reported as part of the pathogenesis of oral submucous fibrosis. A combined approach, including analysis of genetic and epigenetic regulations with different habits, might be helpful to better understand the contributory factors and pathogenesis of this serious disorder.

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Malondialdehyde Levels in Oral Sub Mucous Fibrosis: A Clinicopathological and Biochemical Study

Cited by 22 publications

References 11 publications

Oral submucous fibrosis: A quantitative assessment of serum malondialdehyde, superoxide dismutase and correlation with clinical staging

Oral submucous fibrosis: A quantitative assessment of serum malondialdehyde, superoxide dismutase and correlation with clinical staging

Clinical profile and oral sub mucous fibrosis

Oral submucous fibrosis: A global challenge. Rising incidence, risk factors, management, and research priorities

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