Mammary Blood Flow and Glucose Uptake in Lactating Cows Given Dexamethasone

Hartmann, PE; Kronfeld, D. S.

doi:10.3168/jds.s0022-0302(73)85274-9

Cited by 50 publications

(38 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The proportional decrease in milk yield, and the latency period before milk yield decreased in the present study was similar to those observed in ACTH-and dexamethasone-treated cows [5,20]. The latency period and the rather slow recovery in milk yield following injection of material with a short biological half-live such as dexamethasone suggest that its effect was inductive and not direct.…”

Section: Discussionsupporting

confidence: 66%

See 1 more Smart Citation

Effect of dexamethasone on milk yield and composition in dairy cows

et al. 2000

View full text Add to dashboard Cite

-Dexamethasone was injected in dairy cows in order to get a better insight into the effects of corticosteroids on milk secretion and composition. A single intramuscular dose of 40 mg dexamethasone caused a 45% reduction in milk yield after 24 h; full recovery took 5 d. The secretion of fat, casein and magnesium was not affected by the treatment. Consequently, the concentration of fat, total protein, total casein, magnesium and phosphorus increased then decreased in direct proportion to the changes in milk yield. The secretion of total protein, calcium and phosphorus decreased as a result of the treatment. The concentration of lactose and the monovalent ions (sodium, potassium, and chlorine) was unaffected, and as a result their secretion decreased and returned to pretreatment level in direct inverse proportion to the changes in milk yield. Whey protein secretion decreased for 48 h and was responsible for the decrease in total protein secretion for 48 h. The most profound effect of dexamethasone is the reduction in the secretion of the osmotic components. milk yield / dairy cows / stress / corticosteroids Résumé -Effet de la dexaméthasone sur la production et la composition du lait chez les vaches laitières. La dexaméthasone a été injectée à des vaches laitières afin de mieux comprendre les effets des corticostéroïdes sur la sécrétion et la composition du lait. Une dose unique intramusculaire de 40 mg de dexaméthasone a réduit de 45 % la production de lait après 24 h ; le retour total à la production antérieure a pris 5 jours. La sécrétion des lipides, des caséines et du magnésium n'a pas été affectée par le traitement. En conséquence, la concentration des lipides, des protéines totales, des caséines totales, du magnésium et du phosphore a augmenté puis a diminué proportionnellement aux changements de production laitière. La sécrétion des protéines totales, du calcium et du phosphore a diminué à la suite du traitement. La concentration du lactose et des ions monovalents (sodium, potassium et chlore) est restée inchangée ; leur sécrétion a diminué et est revenue au niveau initial dans une proportion inverse aux modifications de la production laitière. La sécrétion des protéines du lactoserum a diminué pendant 48 h et a été responsable de la diminution de la sécrétion des protéines totales

show abstract

Section: Discussionsupporting

confidence: 66%

“…An adrenocorticotropin hormone (ACTH)-induced elevation in corticosteroids has been reported to negatively affect milk secretion in dairy cows [2][3][4]20]. The decrease in milk secretion is most likely related to the elevation of blood corticosteroids [1,5].…”

Section: Introductionmentioning

confidence: 99%

Effect of dexamethasone on milk yield and composition in dairy cows

et al. 2000

View full text Add to dashboard Cite

show abstract

“…In dairy cattle, it was demonstrated that parenteral administration of glucocorticoids results in greater blood glucose values (Braun et al 1970;Hartmann and Kronfeld 1971;Wierda et al 1987), and a study by Braun et al (1970) indicated that glucocorticoids causing the largest decrease in milk yield also increased concentrations of blood glucose the most. Braun et al (1970) also showed that the uptake of glucose from the blood to the mammary gland was decreased during treatment with glucocorticoids.…”

mentioning

confidence: 99%

“…The volume of dexamethasone used ranged from 2 to 15 mL and 85.1% of sows received between 4 and 10 mL. In dairy cattle, injection of glucocorticoids including dexamethasone has been shown to decrease milk production by 20-50% in the days following administration (Braun et al 1970;Hartmann and Kronfeld 1971;Anderson and Olsson 1984;Wierda et al 1987). It is not known if treatment with glucocorticoids reduces milk yield in lactating sows, and subsequently the growth of their suckling piglets.…”

mentioning

confidence: 99%

“…We did not measure blood glucose concentrations in this study, but it is likely that the reduction in milk production in sows could be at least partially explained by decreased glucose uptake and metabolism in the mammary glands, as is the case in cattle (Hartmann and Kronfeld 1971). Milk yield in sows varies with litter size and the suckling frequency (Špinka et al 1997).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Repeated injections with dexamethasone in healthy lactating sows and the effect on growth rate of their suckling piglets

Norby

Straw

Bartlett³

et al. 2001

Can. J. Anim. Sci.

View full text Add to dashboard Cite

K. 2001. Repeated injections with dexamethasone in healthy lactating sows and the effect on growth rate of their suckling piglets. Can. J. Anim. 81: 593-596. Twelve lactating sows were given two doses of 14 mg of dexamethasone and 12 controls were given two doses (7.0 mL) of physiological saline. During the treatment period, total litter weight gain in litters of dexamethasone-treated sows was significantly less (P = 0.02) than weight gain of control litters.

show abstract

Introduction: Secretory Activation: From the Past to the Future

Neville

Mather

2007

J Mammary Gland Biol Neoplasia

View full text Add to dashboard Cite

This issue of the Journal of Mammary Gland Biology brings a synthesis of the historical data leading to our understanding of the physiology of lactation up to about 1980 with the new technologies and understanding resulting from the molecular revolution in the late 20th century. We focus specifically on the activation of secretion at parturition, and show that the field is ripe for new investigation.

show abstract

Mammary Blood Flow and Glucose Uptake in Lactating Cows Given Dexamethasone

Cited by 50 publications

References 19 publications

Effect of dexamethasone on milk yield and composition in dairy cows

Effect of dexamethasone on milk yield and composition in dairy cows

Repeated injections with dexamethasone in healthy lactating sows and the effect on growth rate of their suckling piglets

Introduction: Secretory Activation: From the Past to the Future

Contact Info

Product

Resources

About