Management and control of yellow fever virus: Brazilian outbreak January-April, 2018

Callender, David

doi:10.1080/17441692.2018.1512144

Cited by 10 publications

(12 citation statements)

References 18 publications

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“…One key driver of emergence is the amplification of rare zoonotic and vector-borne diseases in densely populated regions where infrastructure needs are outpaced by rapid urban developments. This leads to the formation of slums, favorable conditions for viral disease vectors, disparity in access to clean water, sanitation and healthcare, and an increase in close human-animal interaction due to deforestation 13 , 14 . The advantage of using sewage-based surveillance is that it represents the entire population of the catchment area, sample collection is straightforward, and the anonymization by default makes it less challenging to use than patient-based surveillance regarding privacy laws.…”

Section: Introductionmentioning

confidence: 99%

Setting a baseline for global urban virome surveillance in sewage

Nieuwenhuijse¹,

Munnink²,

Phan³

et al. 2020

Sci Rep

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The rapid development of megacities, and their growing connectedness across the world is becoming a distinct driver for emerging disease outbreaks. Early detection of unusual disease emergence and spread should therefore include such cities as part of risk-based surveillance. A catch-all metagenomic sequencing approach of urban sewage could potentially provide an unbiased insight into the dynamics of viral pathogens circulating in a community irrespective of access to care, a potential which already has been proven for the surveillance of poliovirus. Here, we present a detailed characterization of sewage viromes from a snapshot of 81 high density urban areas across the globe, including in-depth assessment of potential biases, as a proof of concept for catch-all viral pathogen surveillance. We show the ability to detect a wide range of viruses and geographical and seasonal differences for specific viral groups. Our findings offer a cross-sectional baseline for further research in viral surveillance from urban sewage samples and place previous studies in a global perspective.

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Section: Introductionmentioning

confidence: 99%

Setting a baseline for global urban virome surveillance in sewage

Nieuwenhuijse¹,

Munnink²,

Phan³

et al. 2020

Sci Rep

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“…Currently, YFV is majorly persevered in jungle environments with sporadic human outbreaks in South America and sub-Saharan Africa. The present risk of emergence and transmission of the disease is being primarily controlled by wide coverage of vulnerable populations with vaccinations [ 45 , 46 ].…”

Section: Flaviviruses and Ocular Complicationsmentioning

confidence: 99%

Ocular Manifestations of Emerging Flaviviruses and the Blood-Retinal Barrier

Singh

Kumar

2018

Viruses

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Despite flaviviruses remaining the leading cause of systemic human infections worldwide, ocular manifestations of these mosquito-transmitted viruses are considered relatively uncommon in part due to under-reporting. However, recent outbreaks of Zika virus (ZIKV) implicated in causing multiple ocular abnormalities, such as conjunctivitis, retinal hemorrhages, chorioretinal atrophy, posterior uveitis, optic neuritis, and maculopathies, has rejuvenated a significant interest in understanding the pathogenesis of flaviviruses, including ZIKV, in the eye. In this review, first, we summarize the current knowledge of the major flaviviruses (Dengue, West Nile, Yellow Fever, and Japanese Encephalitis) reported to cause ocular manifestations in humans with emphasis on recent ZIKV outbreaks. Second, being an immune privilege organ, the eye is protected from systemic infections by the presence of blood-retinal barriers (BRB). Hence, we discuss how flaviviruses modulate retinal innate response and breach the protective BRB to cause ocular or retinal pathology. Finally, we describe recently identified infection signatures of ZIKV and discuss whether these system biology-predicted genes or signaling pathways (e.g., cellular metabolism) could contribute to the pathogenesis of ocular manifestations and assist in the development of ocular antiviral therapies against ZIKV and other flaviviruses.

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“…The risk of outbreak is primarily controlled via vaccination coverage of vulnerable human populations [13]. In Brazil, the vaccination programs have long been restricted to the North and Central regions.…”

Section: Introductionmentioning

confidence: 99%

The Usefulness of a Duplex RT-qPCR during the Recent Yellow Fever Brazilian Epidemic: Surveillance of Vaccine Adverse Events, Epizootics and Vectors

et al. 2021

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From 2016 to 2018, Brazil faced the biggest yellow fever (YF) outbreak in the last 80 years, representing a risk of YF reurbanization, especially in megacities. Along with this challenge, the mass administration of the fractionated YF vaccine dose in a naïve population brought another concern: the possibility to increase YF adverse events associated with viscerotropic (YEL-AVD) or neurological disease (YEL-AND). For this reason, we developed a quantitative real time RT-PCR (RT-qPCR) assay based on a duplex TaqMan protocol to distinguish broad-spectrum infections caused by wild-type yellow fever virus (YFV) strain from adverse events following immunization (AEFI) by 17DD strain during the vaccination campaign used to contain this outbreak. A rapid and more accurate RT-qPCR assay to diagnose YFV was established, being able to detect even different YFV genotypes and geographic strains that circulate in Central and South America. Moreover, after testing around 1400 samples from human cases, non-human primates and mosquitoes, we detected just two YEL-AVD cases, confirmed by sequencing, during the massive vaccination in Brazilian Southeast region, showing lower incidence than AEFI as expected.

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Management and control of yellow fever virus: Brazilian outbreak January-April, 2018

Cited by 10 publications

References 18 publications

Setting a baseline for global urban virome surveillance in sewage

Setting a baseline for global urban virome surveillance in sewage

Ocular Manifestations of Emerging Flaviviruses and the Blood-Retinal Barrier

The Usefulness of a Duplex RT-qPCR during the Recent Yellow Fever Brazilian Epidemic: Surveillance of Vaccine Adverse Events, Epizootics and Vectors

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