Management and Outcome of Recurrent Well-Differentiated Thyroid Carcinoma

Abstract

Background:The AMES (age, distant metastasis, tumor extent, and size), AGES (age, tumor size, histologic grade, tumor extent, distant metastasis), and MACIS (distant metastasis, age, completeness of primary tumor resection, local invasion, and tumor size) prognostic systems for welldifferentiated thyroid carcinoma (WDTC) are well known. The development of disease recurrence is associated with a poor outcome; however, the prognostic importance of multiple treatment failures has not been clearly reported.Objectives: To identify patient, tumor, and treatment factors that may be associated with the development of multiple recurrences in WDTC.Design and Setting: All patients treated for residual or recurrent WDTC were retrospectively identified from the thyroid cancer database at the Department of Otolaryngology-Head and Neck Surgery, Mount Sinai Hospital, Toronto, Ontario (1963-2000. Data on relevant patient, tumor, and treatment factors were collected. Main Outcome Measures: Patient, tumor, and treatment factors predicting the development of multiple treatment failures, disease-specific survival, and overall survival.Results: A total of 574 patients (115 male, 459 female; median age, 42 years [range, 9-92 years]) were identified, whose final histopathologic diagnosis was papillary carcinoma in 468, follicular carcinoma in 76, and ORIGINAL ARTICLE

Well-differentiated thyroid cancer: the Philippine General Hospital experience

“…The mean age at presentation of 44 years and female predominance were also consistent with findings from different international studies [16][17][18]. In contrast, the mean duration of the goiter before initial consult of 6 years and larger mean tumor size reflect the limited access to medical care typical of most patients seen at our institution.…”

Association between prognostic factors and clinical outcome of well-differentiated thyroid carcinoma: A retrospective 10-year follow-up study

“…Although WDTC is the most common type of thyroid carcinoma, it is the only type of this carcinoma with a low mortality rate (15)(16)(17) and increased survival rate; the current study found a rate of mortality of 4% for this condition. However, a number of studies have reported a mortality rate of ≤10% (5,18).…”

Disease Free Survival of Well Differentiated Thyroid Cancer: 20 years Experience at a tertiary care center in Lebanon

“…This is in line with other reports. Palme et al reported that male sex, advanced initial stage, and presence of extra-thyroidal spread were independent predictors of multiple recurrences of DTC [23]. In a retrospective review of papillary micro-carcinoma (≤1cm), Mercante et al found that capsular invasion, extra-thyroidal tumor extension, and neck lymph node metastasis at presentation were the only independent risk factors for the persistence or recurrence of disease [24].…”