Management Comprehensive Multidisciplinary of Malignant Ovarian Germ Cell Tumors and Feto - Maternal Outcome: A Case Series Report and Literature Review

Abstract

BACKGROUND: Malignant Ovarian Germ Cell Tumors (MOGCT) most commonly occur in young women in the reproductive age group. Timely antenatal diagnosis and treatment of the tumour to enhance maternal and perinatal outcomes are the main challenges confronting the obstetrician and the gyne-oncologist.
 CASE PRESENTATION: Here we present three cases of pregnancy complicated with MOGCTs. The first case (immature teratoma) was complicated by maternal psychological symptoms consistent with stress and histopathological examination confirmed the diagnosis of premature ovarian failure (POF). The second case (dysgerminoma) preterm labour occurred as an obstetric complication, but the baby was born in good condition without IUGR. The third case (yolk sac tumour) treated with docetaxel (brexel)-carboplatin chemotherapy administration there was no maternal or fetal complication. At the end of the pregnancy and delivery, complete surgical staging and cytoreduction were performed, and no metastases were found.
 CONCLUSION: Optimal management strategies centre on a multi-disciplinary comprehensive team approach is critical resulting in better outcomes for the mother and the baby by avoiding complications.

The Effect of Application of Audit Digitalization on Auditor Performance With Professional Ethics as a Moderation Variable

“…This means that as the application of audit digitization increases, the performance of auditors also improves. These findings align with previous studies conducted by Luh et al (2019), which also demonstrate a significant impact of information technology on auditor performance. However, these results contradict the research conducted by Sangkala et al (2021), which suggests that the use of information technology does not significantly affect auditor performance.…”

“…The better the utilization of information technology by auditors, the higher their performance is expected to be. Previous research by Sangkala et al (2021) indicated no significant effect of information technology on auditor performance, while studies by Luh et al (2019) found a significant positive effect. Hypothesis 1 (H1): The application of audit digitization has a significant effect on auditor performance.…”

“…Additionally, Abdul & Lilik (2020) demonstrated that professional ethics influence auditor performance, a finding supported by Putri and Novita (2020). Conversely, Luh et al (2019) concluded that professional ethics have a negative effect. These contrasting results highlight the need for further investigation.…”

Reproductive Outcomes and Fertility Preservation Strategies in Women with Malignant Ovarian Germ Cell Tumors after Fertility Sparing Surgery

“…MOGCT is a rare disease that typically present in the teenage years. On the other hand, MOCGT in pregnancy are rare and better maternal and fetal outcomes are the results of a multi-disciplinary comprehensive approach [76]. The tumor is always unilateral and chemo-sensitive.…”