Management, functional outcomes and survival in a French multicentric series of 118 adult patients with cerebellar glioblastoma

Rapid Brainstem Infiltration of a Cerebellar Glioblastoma

“…In a recent study, Picart et al found that the functional outcomes did not correlate with brainstem infiltration and recommended performing an extensive tumor resection when possible [7]. After total or subtotal resection, the functional outcomes correlated with age and cerebellar hemispheric tumor location [7]. The overall median survival of cerebellar and supratentorial glioblastoma is very similar, approximately eight to nine months [8][9][10][11][12].…”

“…The histomolecular profile of cerebellar glioblastoma appears to be different from that of supratentorial gliomas. Cerebellar glioblastoma has no IDH1/2 gene mutations but can harbor an H3 K27M mutation in 10-25% of cases [7,[13][14][15]. Hong et al detected a mutation of IDH1 in two patients with cerebellar glioblastoma who previously had supratentorial anaplastic IDH-mutant gliomas and concluded that some cerebellar glioblastomas are metastasis from supratentorial tumors that spread to the infratentorial area via cerebrospinal fluid pathways or tumor cell migration [16].…”

“…The presence of leptomeningeal disease in cerebellar glioblastoma results in markedly decreased OS and PFS as well [ 1 ]. In a recent study, Picart et al found that the functional outcomes did not correlate with brainstem infiltration and recommended performing an extensive tumor resection when possible [ 7 ]. After total or subtotal resection, the functional outcomes correlated with age and cerebellar hemispheric tumor location [ 7 ].…”

“…Cerebellar glioblastoma is more frequently associated with neurofibromatosis type I [4]. Primary cerebellar glioblastoma with brainstem invasion occurs in 20-33% of the cases [5][6][7]. Although it is recognized that a cerebellar glioblastoma can infiltrate the brainstem, how rapidly this can be accomplished has been unreported.…”

Molecular Characterization of Adult Tumors Diagnosed as Cerebellar Glioblastomas Identifies Subgroups Associated With Prognosis

“…14,15 For this study, adults with cerebellar tumors diagnosed as GBMs based on the WHO 2007 classification between 2003 and 2017 were identified from the FBTDB and the Club de Neuro-Oncologie of the Société Française de Neurochirurgie. 16,17 Inclusion criteria were: (1) age 18 years and above at diagnosis; (2) tumor epicenter located in the cerebellum with a brainstem infiltration ≤ 5 mm; and (3) surgical management between November 1, 2003, and August 1, 2017. Exclusion criteria were: (1) the presence of a supratentorial or medullar tumor larger than the cerebellar tumor; and (2) recurrent tumors.…”