Management of extremity malignant fibrous histiocytoma: A 10-year experience

Chen, Kun Han; Chou, Ting Mao; Shieh, Shyh Jou

doi:10.1016/j.fjs.2014.06.003

Cited by 10 publications

(14 citation statements)

References 17 publications

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“…Imaging like Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) scans play a role in defining the extent of the disease and the treatment is mainly surgical. There may be a role for neoadjuvant/adjuvant radiotherapy [10]. This work has been reported in line with the SCARE criteria [11].…”

Section: Introductionmentioning

confidence: 74%

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Malignant fibrous histiocytoma, now referred to as Undifferentiated Pleomorphic Sarcoma: A Case Report of an unexpected histology of a subcutaneous lesion

Seomangal

Mahmoud

McGrath

2019

International Journal of Surgery Case Reports

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Section: Introductionmentioning

confidence: 74%

“…The main treatment of UPS remains complete surgical excision, with margins of at least 2 cm with a role for neoadjuvant/adjuvant radiotherapy and doxorubicin based chemotherapy [8,10].…”

Section: Discussionmentioning

confidence: 99%

Malignant fibrous histiocytoma, now referred to as Undifferentiated Pleomorphic Sarcoma: A Case Report of an unexpected histology of a subcutaneous lesion

Seomangal

Mahmoud

McGrath

2019

International Journal of Surgery Case Reports

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“…The general outcomes of extremity MFHs are superior to those of head and neck and retroperitoneal MFHs. According to a study conducted by Chen et al 41 , 5-year survival rate is 76.2%. Clinical outcomes of extremity MFHs are associated with multiple factors.…”

Section: Treatmentmentioning

confidence: 99%

Malignant fibrous histiocytoma of the right upper leg: A case report

et al. 2018

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Introduction. Malignant fibrous histiocytoma is a fast spreading pleomorphic sarcoma with a high malignant potential. Its spreading is characterized with local invasion and distant metastazes with early onset. Most common localisations of development are extremities, trunk and retroperitoneum. Given the line of rare case and specimen, lack of a clear etiology and mechanisms of this disease, as well as adequate histopathologic findings and intraoperative documentation, we presented current status, discuss putative etiology, histopathology with variant morphology, differential diagnosis and treatment modalities. Case report. We presented a 56-years-old female Serbian with tumor in the thigh that clinically resembles incapsulated hematoma. Computed tomography revealed intramuscular tumor with a heterodense structure and compression on surround tissue. Ex tempore biopsy specimen showed malignant potential of the tumor. Wide and radical excision of the nodule has been done, and definitive histopathological verification revealed malignant fibrous histiocytoma. Conclusion. Malignant fibrous histiocytoma is a most common type of soft tissue sarcomas in adults. Frequent localization is on lower extremities, and every rapidly enlarging nodule in this localization that on computed tomography is like incapsulated hematoma with necrotic zone should alert suspicion on presence of this type of sarcoma. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. III41007 and Grant no. III41010]

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“…We present this case of a high-grade posterior thigh undifferentiated pleomorphic sarcoma due to the rarity of the disease, the complication of diagnosis due to a patient history of thrombotic thrombocytopenic purpura, and the abnormally large size of the tumor at the time of excision. To our knowledge, this is one of the largest reported UPS that was successfully removed by radical excision [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Large Undifferentiated Pleomorphic Sarcoma of the Posterior Thigh

Allen

2019

Am J Case Rep

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Patient: Female, 62Final Diagnosis: Undifferentiated pleomorphic sarcomaSymptoms: Pain in the legMedication: —Clinical Procedure: Surgical excisionSpecialty: OncologyObjective:Rare diseaseBackground:Sarcomas account for less than 1% of all cancers. Undifferentiated Pleomorphic Sarcoma, formerly called Malignant Fibrous Histiocytoma, is a rare subtype identified by a lack specific immunohistochemical markers for a specific lineage of differentiation. These soft tissue tumors are aggressive and rapidly enlarge. Risk for metastasis increases almost linearly as the tumor increases in size, emphasizing the importance of early detection, treatment, and post-resection monitoring.Case Report:This article reports a case of a large undifferentiated pleomorphic sarcoma of the posterior thigh in a 62-year-old female. Given the patient’s history of thrombotic thrombocytopenic purpure, her initial mass was thought to be a hematoma following a hernia repair surgery. After diagnosis of undifferentiated pleomorphic sarcoma, she underwent radical excision revealing a 24×9.5×7cm lesion – one of the largest reported in the literature.Conclusions:Sarcomas are very rare soft tissue neoplasms, but they should not be excluded in a physician’s differentials when a patient presents with an enlarging soft tissue mass. Because sarcomas enlarge rapidly, delay in evaluation and management should be avoided and these patients should be quickly referred to a center specializing in sarcoma treatment. Magnetic Resonance Imaging (MRI) is the recommended initial imaging for all soft tissue masses of the extremities, trunk, and head and neck while Computed Tomography (CT) is the recommended imaging choice for retroperitoneal and visceral masses. After successful surgical excision with clean margins, patients should undergo serial monitoring by CT or MRI for surveillance of recurrence or late pulmonary metastases.

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Management of extremity malignant fibrous histiocytoma: A 10-year experience

Cited by 10 publications

References 17 publications

Malignant fibrous histiocytoma, now referred to as Undifferentiated Pleomorphic Sarcoma: A Case Report of an unexpected histology of a subcutaneous lesion

Malignant fibrous histiocytoma, now referred to as Undifferentiated Pleomorphic Sarcoma: A Case Report of an unexpected histology of a subcutaneous lesion

Malignant fibrous histiocytoma of the right upper leg: A case report

Large Undifferentiated Pleomorphic Sarcoma of the Posterior Thigh

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