Management of <i>Helicobacter pylori</i> Infection: A Comparison between Korea and the United States

Kim, Sung Eun; Hwang, Joo Ha

doi:10.5009/gnl210224

Cited by 7 publications

(4 citation statements)

References 37 publications

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“…Contrarily, persistent atrophic gastritis and cancer are brought on by low gastric acid output. [73][74][75][76][77][78][79] Patients with H. pylori infection had significantly higher levels of acid production and duodenal ulceration, suggesting that acid plays a crucial role in developing gastric mucosal ulcers. It has been demonstrated that a low pH (very acidic pH) enhances NF-kB binding caused by H. pylori.…”

Section: Chemistryselectmentioning

confidence: 99%

“…Antrum‐predominant gastritis and duodenal ulcers are more likely to occur in people with high gastric acid output. Contrarily, persistent atrophic gastritis and cancer are brought on by low gastric acid output [73–79] . Patients with H. pylori infection had significantly higher levels of acid production and duodenal ulceration, suggesting that acid plays a crucial role in developing gastric mucosal ulcers.…”

Section: Gastro‐protective Activities Of a Marmaelosmentioning

confidence: 99%

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Evaluating the Anti‐Gastric Ulcer Activity ofAegle marmelos: A Brief Review

et al. 2023

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Gastric ulcer is a deep hole in the stomach wall that penetrates the entire mucosa. About 10 % of the world population suffers from gastrointestinal tract disorders frequently known as gastric ulcers. Synthetic drugs are used to prevent gastric ulcers by suppressing the formation of gastric acid or stopping bacterial infections, however, these synthetic drugs have a number of harmful effects. Therefore, drug candidates with improved potency and minimal toxicity are crucial for the treatment and management of gastric ulcers. Recently, there has been a lot of interest in the medicinal potential of plants and their ability to treat gastric ulcers. There is an urgent need for herbal remedies to treat ulcers, and Aegle marmelos presents a better option due to scientifically proven antibacterial and antiulcer properties. In this context, A. marmelos highlights various benefits including anti-inflammatory and antioxidant properties. It is well known that every component of A. marmelos has therapeutic and medical use. The two main causes of stomach ulcers are Helicobacter pylori and NSAIDs. A. marmelos shows strong antioxidant and antiulcer effects and guard against H. pylori-caused ulcers on the stomach mucosa by inhibiting secretory factors and activating antioxidant processes.

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Section: Chemistryselectmentioning

confidence: 99%

Section: Gastro‐protective Activities Of a Marmaelosmentioning

confidence: 99%

Evaluating the Anti‐Gastric Ulcer Activity ofAegle marmelos: A Brief Review

et al. 2023

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“…Global comparison of the proportion of antimicrobial-resistant Helicobacter pylori strains. Data were obtained from reports published since 2012 [45][46][47][48][49][50][51][52][53][54]. Multidrug-resistant strains were defined as those resistant to at least two antimicrobial agents.…”

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confidence: 99%

Optimizing Helicobacter pylori Treatment: An Updated Review of Empirical and Susceptibility Test-Based Treatments

et al. 2023

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As the rate of discovery of drug-resistant Helicobacter pylori cases increases worldwide, the relevant societies have updated their guidelines for primary eradication regimens. A promising strategy against drug-resistant H. pylori is tailored therapy based on the results of an antibiotic susceptibility test; however, it is difficult to apply this strategy to all cases. Although culture-based antibiotic susceptibility tests can assess resistance to any antimicrobial agent, their greatest disadvantage is the time required to draw a conclusion. In contrast, molecular-based methods, such as polymerase chain reaction, can rapidly determine the presence of resistance, although a single test can only test for one type of antimicrobial agent. Additionally, the limited availability of facilities for molecular-based methods has hindered their widespread use. Therefore, low-cost, minimally invasive, simple, and effective primary regimens are needed. Several studies have compared the efficacy of the latest primary eradication regimens against that of tailored therapies, and their results have shaped guidelines. This article reviews the latest research on empirical and tailored treatments for H. pylori infections. Evidence for the superiority of tailored therapy over empirical therapy is still limited and varies by region and treatment regimen. A network meta-analysis comparing different empirical treatment regimens showed that vonoprazan triple therapy provides a superior eradication effect. Recently, favorable results towards vonoprazan dual therapy have been reported, as it reached eradication levels similar to those of vonoprazan triple therapy. Both vonoprazan dual therapy and tailored therapy based on antibiotic susceptibility tests could contribute to future treatment strategies.

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“…While the cure for H. pylori after treatment can be assessed using the 13C-urea breath test (UBT) or stool antigen test at least 4 weeks after treatment, until recently, guided therapy necessitated endoscopic diagnosis with biopsy-based methods that required the intervention of gastroenterologists [ 10 ]. The recent development and excellent performance of several real-time PCR techniques to detect Helicobacter pylori infection and clarithromycin resistance mutations in non-invasive samples (patient stool) provide general practitioners with a tool that can be used in routine diagnostic situations [ 11 ].…”

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confidence: 99%