Management of infertile patients with chronic endometritis

Abstract

Introduction. Chronic endometritis complicates infertility management that sets the task of searching new approaches of treatment. Special attention is paid to the use of enzymatic drugs that improve repair processes. Аim. Тo evaluate the effect of the bovgialuronidasa azoxymer on the restoration of the morphofunctional state of the endometrium and receptor apparatus in infertile women with chronic endometritis. Materials and methods. Forty-seven reproductive age women who applied for infertility with chronic endometritis were examined. The general, somatic, and gynecological history assessment has been carried out. Complaints included the pain syndrome (100 %), discharge from the genital tract (100 %), and the pain during palpation and uterine traction (89.4 %). Paipel-biopsy was carried out with subsequent morphological and cultural study of the endometrium. The immunohistochemical analysis was carried out, and endometrial receptivity was studied. The middle M-echo was detected. Statistical processing was carried out using the Microsoft Exel application package (2010), STATISTICA 13.3 (USA, Tibco). Results. Diagnostic measures including cultural and morphological examination of the endometrium allows to verify chronic endometritis. The use of this protocol allows half of infertile women with chronic endometritis to achieve pregnancy. The use of bovgialuronidasa azoxymer increases rate of pregnancy on 23.9 %. Conclusion. Treatment under this protocol allows half of the patients with infertility due to chronic endometritis, including autoimmune one, to achieve pregnancy.