The article is devoted to the problems of innovation implementation in a modern enterprise. The article reflects human resources' effective use in the conditions of instability of the external environment and personnel's irrational behaviour. The paper offers some psychological tools and principles of modern personnel policy of innovation implementation at the enterprise. The article proposes to use a new wage system based on the model of competencies with specific indicators of manifestation in professional activity, as a means of material stimulation of innovative activity at the enterprise. To effectively introduce innovations at the enterprise, the article suggests several areas of personnel work with personnel: training seminars on revealing to personnel the validity and practicality of innovative transformations taking place at the enterprise; identification of innovative generators among the staff, mentors who have an active, innovative work position, can promote the ideas of new innovative competencies, etc. The study results can be used by managers and employees of the HR management Department in practice when developing strategic and tactical measures for implementing and stimulating innovative processes at the enterprise.