The coronavirus pandemic caused serious damage to most of the world's economies, and Russia is no exception. This means, that an effective mechanism, that will not only make up emersed losses but also achieve economic growth. The hypothesis of the study is the assumption, that the production orientation of the regions, based on industrial enterprises, actively using innovative digital technologies, will help overcome the emersed gap. The performed work, based on the methods of statistical and comparative analysis, using economic and mathematical devices, made it possible to confirm the previously stated assumptions about the existing dependence of the economic achievements of the regions on the level of work of enterprises, that actively use digital technologies. The spread of digital technologies depends on the innovative orientation of the regions, which is formed as a result of the focused actions of regional authorities and business.