Mandatory notifications of type 1 diabetes incident cases in Chilean children, 2006 to 2014: A population‐based study

Garfias, Carolina; Borzutzky, Arturo; Ugarte, Maria F.; García, Hernán; Phingsthorn, Martin; García, Hernán G.

doi:10.1111/pedi.12937

Cited by 8 publications

(10 citation statements)

References 20 publications

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“…This rate of increase is substantially higher than the 3–5% seen in a number of high‐income countries over the last couple of decades . Similar rates though have been seen in other middle‐income countries – such as 13.4% in Chile, 12.0% in China and 12.8% in Bangladesh . It is possible that the impact of changing environmental triggers and factors important in T1D causation is occurring more quickly in some middle‐income countries.…”

Section: Discussionmentioning

confidence: 60%

Incidence, prevalence and mortality of diabetes in children and adolescents aged under 20 years in the Republic of Maldives

Majeed

Shiruhana

Maniam³

et al. 2019

J Paediatrics Child Health

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Aim: There is little published data on diabetes in youth in the Maldives. This study aimed to determine incidence, prevalence and mortality of diabetes in children and adolescents <20 years. Methods: Data on all known existing cases in 2009 and all new cases from 2009 to 2018 was collected from the Diabetes Society of the Maldives registry. Results: Thirty-nine subjects <20 years were known to have diabetes at the start of 2009 and 92 new cases were diagnosed from 2009 to 2018. Of the 92 new cases, 76 had type 1 diabetes (T1D), 15 type 2 diabetes (T2D) and one secondary diabetes. Of the 76 new T1D cases, 64 were diagnosed <15 years. Mean age of onset for T1D <20 years was 10 AE 4.6 years, with 42 (55.3%) female. Ten (13.2%) were diagnosed 0-4 years, 27 (35.5%) 5-9 years, 27 (35.5%) 10-14 years and 12 (15.8%) 15-19 years. Annual T1D mean incidence rates/per 100 000 subjects for <15/<20 years, respectively, increased from 3.6/2.7 in 2009 to 11.0/9.1 in 2018, representing 12.0%/13.0% annualised increases (P = 0.01 for both). T1D prevalence in 2018 for <15 and <20 years was 47.1/100 000 and 52.0/100 000, respectively. No young person with T1D died during this period, with a total of 262 patient-years of follow-up for T1D cases. The child with secondary diabetes died of other causes. Conclusion: T1D incidence in Maldives is higher than that reported from other South Asian countries, and an increasing trend was observed. T2D also occurs relatively frequently. A zero mortality rate was observed for children and young adults with T1D and T2D from 2009 to 2018.

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Section: Discussionmentioning

confidence: 60%

Incidence, prevalence and mortality of diabetes in children and adolescents aged under 20 years in the Republic of Maldives

Majeed

Shiruhana

Maniam³

et al. 2019

J Paediatrics Child Health

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“…1,2,9 Incidence is highest in northern-European-origin populations, and also some Arab populations in the Middle East and North Africa. [10][11][12] With respect to neighboring countries to Dominican Republic that have 0-14 y data, the identified incidence of 4.3 per 100,000 population was higher than Colombia and Bolivia (both 2.2), 13,14 and Mexico (3.2), 15 but substantially lower than Chile (13.9) 16 and Brazil (16.3). 17 The reasons for the wide variation in the region are unclear.…”

Section: Discussionmentioning

confidence: 99%

Incidence of type 1 diabetes in children in Dominican Republic, 2010–2019: A national collaborative study

Morla¹,

Ibrahim

James

et al. 2022

Pediatric Diabetes

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The Dominican Republic has no recent data on type 1 diabetes (T1D) incidence in children. Therefore, a study was undertaken to determine this in persons aged <15 years (y). Data were collected on all new T1D diagnoses between 2010–2019 from the four institutions caring for children with T1D. Diagnosis was made according to standard criteria. No secondary ascertainment source was available. The trend and the effect of age and sex of T1D incidence was analyzed using Poisson regression. A total of 1224 new cases of T1D were diagnosed <15 y; mean ± standard deviation (range) 122 ± 12 (96–135) cases per year. Age at T1D diagnosis was 8.8 ± 3.7 y, with a significant female preponderance (n = 708, 57.8%, p < 0.001). When examined per 5‐y age group, cases were consistently highest in 10–14 y, and lowest in 0–4 y in all study years. Mean crude T1D annual incidence was 4.3 (95% CI 3.5–5.1) per 100,000 population. There was no significant difference between incidence across the country's three departments (regions): Southeast (4.4 [3.4–5.7]/100,000 population), North (4.1 [2.9–5.6]), and Southwest (3.9 [2.4–5.9]). Mean standardized annual incidence was 4.1 (4.1–4.2) per 100,000 population, with no significant trend of increase over the study period. The incidence of T1D in children aged <15 y is relatively low in Dominican Republic, but consistent with the limited data from other countries in the region. However, the incidence is eight times higher than the previous estimate during 1995–1999. Ongoing surveillance is warranted.

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“…According to a 2019 International Diabetes Federation, the global prevalence of Diabetes is 463 million people and 578 million people will be affected by 2030 (1). Furthermore, Type 1 DM (T1DM) incidence has increased worldwide over the last decades (2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

Urinary Extracellular Vesicles as a Source of NGAL for Diabetic Kidney Disease Evaluation in Children and Adolescents With Type 1 Diabetes Mellitus

Ugarte

Santapau

Gallardo³

et al. 2022

Front. Endocrinol.

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BackgroundTubular damage has a role in Diabetic Kidney Disease (DKD). We evaluated the early tubulointerstitial damage biomarkers in type-1 Diabetes Mellitus (T1DM) pediatric participants and studied the correlation with classical DKD parameters.MethodsThirty-four T1DM and fifteen healthy participants were enrolled. Clinical and biochemical parameters [Glomerular filtration Rate (GFR), microalbuminuria (MAU), albumin/creatinine ratio (ACR), and glycated hemoglobin A1c (HbA1c)] were evaluated. Neutrophil gelatinase-associated lipocalin (NGAL), Hypoxia-inducible Factor-1α (HIF-1α), and Nuclear Factor of Activated T-cells-5 (NFAT5) levels were studied in the supernatant (S) and the exosome-like extracellular vesicles (E) fraction from urine samples.ResultsIn the T1DM, 12% had MAU >20 mg/L, 6% ACR >30 mg/g, and 88% had eGFR >140 ml/min/1.72 m2. NGAL in the S (NGAL-S) or E (NGAL-E) fraction was not detectable in the control. The NGAL-E was more frequent (p = 0.040) and higher (p = 0.002) than NGAL-S in T1DM. The T1DM participants with positive NGAL had higher age (p = 0.03), T1DM evolution (p = 0.03), and serum creatinine (p = 0.003) than negative NGAL. The NGAL-E correlated positively with tanner stage (p = 0.0036), the median levels of HbA1c before enrollment (p = 0.045) and was independent of ACR, MAU, and HbA1c at the enrollment. NFAT5 and HIF-1α levels were not detectable in T1DM or control.ConclusionUrinary exosome-like extracellular vesicles could be a new source of early detection of tubular injury biomarkers of DKD in T1DM patients.

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Mandatory notifications of type 1 diabetes incident cases in Chilean children, 2006 to 2014: A population‐based study

Cited by 8 publications

References 20 publications

Incidence, prevalence and mortality of diabetes in children and adolescents aged under 20 years in the Republic of Maldives

Incidence, prevalence and mortality of diabetes in children and adolescents aged under 20 years in the Republic of Maldives

Incidence of type 1 diabetes in children in Dominican Republic, 2010–2019: A national collaborative study

Urinary Extracellular Vesicles as a Source of NGAL for Diabetic Kidney Disease Evaluation in Children and Adolescents With Type 1 Diabetes Mellitus

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