Mangifera indica L. Leaf Extract Induces Adiponectin and Regulates Adipogenesis

Abstract

Natural bioactive compounds may be used in obese patients because of their ability to impact on various key mechanisms involved in the complex pathophysiological mechanisms of such condition. The aim of this study was to investigate the effect of a Mangifera indica L. leaf extract (MLE) on adipogenic differentiation of murine preadipocyte cells. 3T3-L1 cells were treated during their differentiation with various concentrations of (Mangifera indica L.) leaves extract (MLE) (750, 380, 150, 75 and 35 μg) in order to assess their lipid content, adiponectin production, expression profile of genes involved in lipid metabolism, oxidative stress and inflammation. Our results showed that MLE was particularly enriched in polyphenols (46.30 ± 0.083 mg/g) and that pharmacological treatment of cells resulted in a significant increase of adiponectin levels and reduction of intracellular lipid content. Consistently with these results, MLE resulted in a significant decrease of the expression of genes involved in lipid metabolism (FAS, PPARG, DGAT1, DGAT2, and SCD-1). In conclusion, our results suggest that MLE may represent a possible pharmacological tool for obese or metabolic syndrome patients.

Bio-Waste Products of Mangifera indica L. Reduce Adipogenesis and Exert Antioxidant Effects on 3T3-L1 Cells

“…A vast literature highlights how different parts of the plant (leaves, flowers and bark) and of the fruit (peel, pulp and seed) contain phytochemicals capable of exerting anti-inflammatory, anti-oxidant and anti-tumoral effects [ 20 , 21 , 22 , 23 ]. Furthermore, mango pulp and leaf extracts have been reported to inhibit adipogenesis in mouse 3T3-L1 cells and improve plasma levels of pro-inflammatory cytokines in obese patients [ 24 , 25 ]. The nutraceutical properties of mango are linked to the presence of a wide range of polyphenols, including mangiferin, gallic acid, gallotannins, quercetin, isoquercetin, ellagic acid and β-glucogallin [ 20 , 22 ].…”

Potential Therapeutic Activity of Mango (Mangifera indica L.) Leaves on Excess Consumption of Fructose in Rats

“…Mango leaves active constituents regulated fat metabolic pathways through controlling of different genes expression in rats causing an amelioration in fat deposition in the rat's body and correction of obesity markers and body weight. This is due to mango leaves fiber and polyphenolic active components that modulate the expression of transcriptional factors and enzymes related to adipogenesis [33][34][35].…”

“…Proinflammatory adipokines (such as TNF-α) and anti-inflammatory adipokines (i.e., adiponectin) are two types of cytokines. Adipocyte function is disrupted in obesity, with increased expression of proinflammatory adipokines and decreased expression of anti-inflammatory adipokines, resulting in a chronic, low-grade inflammatory state [35].…”

“…Mango leaves supplemented and treated rats showed decreased levels of pro-inflammatory cytokines as TNF-α and leptin with increasing anti-inflammatory adiponectin. This is attributed to anti-inflammatory characteristics of mango leaves active components including polyphenols and flavonoids making mango leaves as a good functional food for obese and metabolic syndrome individuals [35,29].…”

A review of the pharmacological effects of Anacardiaceae family on controlling lipid profile (dyslipidemia)

“…Fifteen species of the Anacardiaceae family were selected to be reviewed for their pharmacological effects on controlling the lipid profile of dyslipidemia. Those species are Anacardium occidentale [17][18][19][20][21], Buchanania lanzan Spreng [22], Lennea edulis [23], Mangifera indica [24][25][26][27][28], Pistacia atlantica [29], Pistacia khinjuk [30], Pistacia lentiscus [31][32][33], Pleiogynium timorense [34], Protorhus longifolia [35], Rhus coriaria [36][37][38][39][40], Rhus mysurensis Heyne [41], Rhus verniciflua [42], Schinus terebinthifolius [43], Semecarpus anacardium [44,45], and Spondias pinnata [46,47]. As those species are varied, their substances are different, leading to their variety of pharmacological effects.…”