Manipulating exciton dynamics of thermally activated delayed fluorescence materials for tuning two-photon nanotheranostics

Abstract

Exciton dynamics can be manipulated rationally in the design of TADF materials for nanotheranostics. Regulating the ΔEST and f promises efficient energy flow for tailoring balances between singlet oxygen generation and fluorescence emission.

Review of nanotheranostics for molecular mechanisms underlying psychiatric disorders and commensurate nanotherapeutics for neuropsychiatry: The mind knockout

“…Implementing the novel concept of nanotechnology in neuroscience by using newly designed nanotheranostics and nanotherapeutics are the recent trends and new avenues for treating neurological and mental disorders. Some of them can act all together as nanotheranostics and nanotherapeutics, and such abilities very well appreciated and implemented in diagnosis and therapy 67 . These strategies gained a lot of scientific interest and must implement for the diagnosis of neuropsychiatry.…”

Molecular Design of Highly Efficient Heavy‐Atom‐Free Triplet BODIPY Derivatives for Photodynamic Therapy and Bioimaging

“…Recently, the concept of tuning the energy gap between the lowest singlet excited state and the lowest triplet state (Δ E ST ) to harvest triplet excited state has been introduced to the field of PS, and these PSs are constructed based on twisted donor–acceptor (D–A) systems with small Δ E ST to facilitate the ISC process; however, the low molar extinction coefficients of these PSs in the visible region still need to be addressed . Along with this issue, the manipulation of Δ E ST for balancing ROS generation and fluorescence emission should be considered to develop PSs with excellent dual‐functionality . Taking the abovementioned factors into account, we envisage that a promising molecular design approach to heavy‐atom‐free BODIPY PSs for image‐guided PDT can be achieved by considering the following aspects: 1) A triplet BODIPY with a suitable Δ E ST value and large molar extinction coefficient in the visible region can be realized by connecting a donor and BODIPY acceptor via a phenyl linker to construct a twisted D‐BODIPY structure; 2) the twisted conformation of the target D–BODIPY structures may reduce the intermolecular π–π interaction, avoiding serious ACQ effects; 3) far‐red/near‐infrared emissive BODIPYs with a large Stokes shift can be obtained based on D‐BODIPY structures through a twisted intramolecular charge‐transfer (TICT) transition …”

A 9-fluorenyl substitution strategy for aromatic-imide-based TADF emitters towards efficient and stable sky blue OLEDs with nearly 30% external quantum efficiency

“…3,4 This near unity IQE can be achieved by exploiting triplet excitons via efficient reverse intersystem crossing (RISC), in which a necessary small energy gap (DE ST ) between the lowest singlet (S 1 ) and triplet (T 1 ) states is required. [5][6][7] A small DE ST that can be controlled by the twisted donor (D) and acceptor (A) moieties of TADF molecules is beneficial to triplet excitons up-conversion to S 1 states. 8 The effective separation between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) can be garnered by the structural distortion of D/A.…”