Manipulation of inositol metabolism for improved plant survival under stress: a “network engineering approach”

Osmoprotection in plants under abiotic stresses: new insights into a classical phenomenon

“…Myo-inositol (cyclohexane hexol) is a sugar-like unique carbohydrate, which is critically important for a myriad of plant cellular processes (Valluru and Van den Ende 2011;Nisa et al 2016). Besides performing basic cellular functions, inositol is also found to contribute as an osmoprotectant for plant protection against abiotic stress (Sengupta et al 2012). Moreover, this compound is reported to control the transport of plant hormones such as auxins, membrane biogenesis, phytic acid biosynthesis, signal transduction, plant immunity and programed cell death (Hazra et al 2019).…”

“…It has been observed that under salinity stress, inositol functions in two ways: as a protectant against ROS and as a controller of cell water potential. Of the seven isomers of inositol, myo-inositol is the most abundant (Sengupta et al 2012). The glycosidic linkage present in inositol and its derivates (pinitol, galactinol, and ononitol) is not hydrolysis-labile and owing to this property, inositol derivatives are among the most stable compounds in the plant cell (Valluru and Ende 2011).…”

“…The biosynthesis of inositol is a two-step biochemical pathway that involves enzymatic conversion of d-glucose-6-P into myo-inositol-1-P mediated by myo-inositol-1-P synthase (Majumder et al 1997), followed by dephosphorylation of myo-inositol-1-P resulting in myo-inositol that further produces different inositol containing compounds such as phospholipids (Dastidar et al 2006). There is great potential to use genetic engineering to increase production of myo-inositol and its derivatives in transgenic crop plants which could thrive well under adverse environmental conditions (Sengupta et al 2012). For example, Nisa et al (2016) transferred GsMIPS2, the myo-inositol-1-phosphate synthase biosynthesis gene from Glycine soja (wild soybean) into Arabidopsis and observed increased tolerance of salt stress.…”

Combining Physiological and Metabolomic Analysis to Unravel the Regulations of Coronatine Alleviating Water Stress in Tobacco (Nicotiana tabacum L.)

“…Myo-inositol is the most abundant form of naturally existence isomers of inositols and imparts abiotic stress tolerance to plants. It also serves as the precursor of the synthetic route of the galactinol and raffinose family oligosaccharides (RFO), which may act as sugar signals in abiotic stresses, like glucose and fructose [50]. The increased level of myo-inositol may combat PEG-simulated osmotic stress due to its hydroxyl groups, which can generate a sphere of hydration around macromolecules [51].…”

Genome-wide analysis of Myo-inositol oxygenase gene family in tomato reveals their involvement in ascorbic acid accumulation

“…MI is also involved in different processes, including phosphatidylinositol (PtdIns) signaling pathway, cell wall biosynthesis, phytic acid biosynthesis, auxin storage, and transport, and the production of stress-related molecules [6]. In plants, MI is one of the most abundant forms of inositol [7] synthesized from glucose by the enzymes, L-myo-inositol 1-phosphate synthase (MIPS), and inositol monophosphate phosphatase (IMPase) [6]. The MI oxidation pathway (MIOP) consumes MI and considered a critical route for cell wall polysaccharide synthesis [5].…”