Maniwamycins: new quorum-sensing inhibitors against Chromobacterium violaceum CV026 were isolated from Streptomyces sp. TOHO-M025

Fukumoto, Atsushi; Murakami, Chikana; Anzai, Yojiro; Kato, Fumio

doi:10.1038/ja.2015.126

Cited by 34 publications

(48 citation statements)

References 27 publications

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“…The unremitting discovery of antibiotics showed a promising prospect for the bacterial infections, but also resulted in the serious resistance of antibiotics. Bacteria have evolved a variety of resistance mechanisms [1,2]. Quorum sensing (QS) is the regulation of gene expression in response to fluctuations in cell-population density among diverse bacterial species [3].…”

Section: Introductionmentioning

confidence: 99%

“…The EtOAc extract of the fermentation broth of this fungus showed obvious QS inhibitory activity against Chromobacterium violaceum CV026. Subsequent chemical investigation on the EtOAc extract of the fermentation broth had led to the isolation of five new compounds, named altertoxins VIII-XII (1)(2)(3)(4)(5), as well as a known one, cladosporol I (6) [10] (Figure 1). All of the new compounds showed obvious QS inhibitory activities.…”

Section: Introductionmentioning

confidence: 99%

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Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33

et al. 2020

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Five new perylenequinone derivatives, altertoxins VIII–XII (1–5), as well as one known compound cladosporol I (6), were isolated from the fermentation broth of the marine-derived fungus Cladosporium sp. KFD33 from a blood cockle from Haikou Bay, China. Their structures were determined based on spectroscopic methods and ECD spectra analysis along with quantum ECD calculations. Compounds 1–6 exhibited quorum sensing inhibitory activities against Chromobacterium violaceum CV026 with MIC values of 30, 30, 20, 30, 20 and 30 μg/well, respectively.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33

et al. 2020

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“…In recent years, natural resources from plants and microorganisms have received attention as sources of bacterial QS inhibitors26. Known compounds that have been demonstrated to inhibit the bacterial QS system include p -coumaric acid from garlic extract27, methyl eugenol from Cuminum cyminum 28, baicalein from Scutellaria baicalensis 29, curcumin from Curcuma longa 30, maniwamycins from Streptomyces sp 31,. unidentified secondary metabolites from marine Streptomyces 32, furanosesterterpenes from the marine sponge Ircinia felix 33, sesqui- and triterpenoids from the liverwort Lepidozia chordulifera 34, and unidentified components from edible mushrooms3536.…”

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confidence: 99%

A diketopiperazine factor from Rheinheimera aquimaris QSI02 exhibits anti-quorum sensing activity

Sun

Dai

Sun

et al. 2016

Sci Rep

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An ethyl acetate (EtOAc) extract isolated from the marine bacterium, Rheinheimera aquimaris QSI02, was found to exhibit anti-quorum sensing (anti-QS) activity. A subsequent bioassay-guided isolation protocol led to the detection of an active diketopiperazine factor, cyclo(Trp-Ser). Biosensor assay data showed that the minimum inhibitory concentration (MIC) of cyclo(Trp-Ser) ranged from 3.2 mg/ml to 6.4 mg/m for several microorganisms, including Escherichia coli, Chromobacterium violaceum CV026, Pseudomonas aeruginosa PA01, Staphylococcus aureus, and Candida albicans. Additionally, sub-MICs of cyclo(Trp-Ser) decreased the QS-regulated violacein production in C. violaceum CV026 by 67%. Furthermore, cyclo(Trp-Ser) can decrease QS-regulated pyocyanin production, elastase activity and biofilm formation in P. aeruginosa PA01 by 65%, 40% and 59.9%, respectively. Molecular docking results revealed that cyclo(Trp-Ser) binds to CviR receptor more rigidly than C6HSL with lower docking energy −8.68 kcal/mol, while with higher binding energy of −8.40 kcal/mol than 3-oxo-C12HSL in LasR receptor. Molecular dynamics simulation suggested that cyclo(Trp-Ser) is more easy to bind to CviR receptor than natural signaling molecule, but opposite in LasR receptor. These results suggest that cyclo(Trp-Ser) can be used as a potential inhibitor to control QS systems of C. violaceum and P. aeruginosa and provide increased the understanding of molecular mechanism that influences QS-regulated behaviors.

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“…Antibiotic compound that produced by S. prasinopilosus was identified as maniwamycins [37], it antibiotic were found to be azoxy substances and showed broad antifungal spectra. Fukumoto [38] found that maniwamycins is able to inhibit violacein synthesis, which is controlled by quorum sensing in Chromobacterium violaceum. Similarly, isolate S. prasinopilosus PN-TN2 also interferes with the quorum sensing process in S. marcescens so that although the growth of bacteria was not inhibited but they cannot synthesize the red pigment (prodigiosin) which is an important virulence factor and produced by quorum sensing process.…”

Section: Molecular Identification Of Potential Actinomycetesmentioning

confidence: 99%

Antimicrobial Production by an Actinomycetes Isolated from The Termite Nest

Krishanti¹,

Zulfina

Wikantyoso

et al. 2018

J.Trop.Life.Science

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Actinomycetes are Gram positive bacteria that have been detected in diverse ecological niches. Their member species are known to be a main source of various bioactive compounds. The discovery of Actinomycetes from diverse and unexplored resources has also been linked to increased opportunities to obtain novel bioactive compounds. Insect nest material is being investigated as a new source of novel antimicrobial producing Actinomycetes, which could be harnessed for therapeutic potential. A total of 10 Actinomycetes isolates were collected from the nest of Nasutitermes sp. in Pananjung Pangandaran Nature Reserve. These isolates were evaluated for antimicrobial activity against the challenge bacteria (Eschericia coli, Staphylococcus aureus, Bacillus subtilis, Serratia marcescens) and fungi (Fomitopsis palustris, Fusarium oxysporum, Trichoderma viridae) by dual culture method. The result revealed that several isolates were active against fungi and bacteria. Isolate Pn-TN2 showed the highest level of antibacterial inhibition and the highest antifungal inhibition with Inhibition Rate value more than 80%. By morphological and 16S rRNA gene sequence analysis strongly suggested that the isolate Pn-TN2 belonged to Streptomyces prasinopilosus. We suggested that termite nest is a potential source of bioactive strains of cultivable Actinomycetes for future biotechnological needs. active compounds for further biotechnology application in the medical, pharmaceutical, and agricultural fields.

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Maniwamycins: new quorum-sensing inhibitors against Chromobacterium violaceum CV026 were isolated from Streptomyces sp. TOHO-M025

Cited by 34 publications

References 27 publications

Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33

Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33

A diketopiperazine factor from Rheinheimera aquimaris QSI02 exhibits anti-quorum sensing activity

Antimicrobial Production by an Actinomycetes Isolated from The Termite Nest

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