Mannheimia haemolytica serotype 1 and Pasteurella trehalosi serotype 10 culture supernatants contain fibrinogen-binding proteins

Pathogenesis and Pathology of Bovine Pneumonia

“…Fibrinogen-binding proteins have been identified. 21 Neuraminidase and sialoglycoprotease modify cell surfaces and may enhance bacterial adhesion. M haemolytica LPS has typical endotoxic and proinflammatory properties, causes vasculitis, and complexes with LKT enhancing LKT receptor production and augmenting LKT activity.…”

“…38 Fibrinogen-binding proteins have been identified. 21 Adhesion to epithelial surfaces could be mediated by the two OmpA molecules expressed in B trehalosi. 39 Identification of pathogenic bacteria at necropsy depends on many factors, including type and number of antimicrobial treatments, extent of tissue decomposition, sample collection, holding, and shipping methods, transit time to laboratory, and method of bacterial detection.…”

Efficacy of a multivalent modified-live virus vaccine containing a Mannheimia haemolytica toxoid in calves challenge exposed with Bibersteinia trehalosi

“…21 Fibrinogen-binding proteins have been found in supernatants of both M haemolytica and B trehalosi, and evaluation of western blots has revealed that the fibrinogen molecules are of a similar size. 22 A protease has been identified in B trehalosi that is similar to a protease in M haemolytica. For both organisms, prechallenge sera neutralizes protease activity, which results in lower lung lesion scores and suggests an immune response to protease is important in protection against both B trehalosi and M haemolytica.…”

The Results of the Selection of Mannheimia Haemolytica’s New Strain “Kl-Viev” for the Production of Specific Prevention Agents for Manheimia of Large and Small Cattle

“…В нашем случае, в связи с биологическими особенностями Mannheimia haemolytica, восприимчивыми к заражению являются исключительно жвачные животные, при этом воспроизвести инфекцию, а соответственно и определить иммуногенную активность, достаточно сложно, так как лабораторные животные сложно поддаются инфицированию. Именно данная особенность обуславливает выбор метода контроля активности посредством определения титра антител [4,6,7,8,11,14].…”