Mannitol: physiological functionalities, determination methods, biotechnological production, and applications

Chen, Ming; Zhang, Wenli; Wu, Hao; Guang, Cuie; Mu, Wanmeng

doi:10.1007/s00253-020-10757-y

Cited by 61 publications

(31 citation statements)

References 47 publications

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“…Mannitol is a naturally occurring six-carbon sugar alcohol that has a wide range of applications in the food and pharmaceutical industries due to its low metabolism and nonglycaemic index properties that make it less susceptible to oxidation in air. Mannitol is soluble in water and maintains good stability in aqueous solutions of acids/bases [31,32]. In addition, it is soluble in glycerol, pyridine, and aniline, but slightly soluble in ethanol.…”

Section: Introductionmentioning

confidence: 99%

A Novel Curcumin-Based Drug Powder Inhalation Medicine for Chronic Obstructive Pulmonary Disease

Shen

Jiang²,

Chen

et al. 2021

Bioinorganic Chemistry and Applications

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The dry powder inhaler is a new form of drug delivery that is widely used as an alternative to traditional drug delivery methods, addressing the shortcomings of traditional drug delivery methods and obtaining better therapeutic results. This mode of delivery is also one of the most rational ways to treat pulmonary diseases such as chronic obstructive pulmonary disease (COPD). Curcumin, a natural polyphenol, has been shown to be effective in the treatment of COPD. In this study, different concentrations of curcumin ethanol solution were spray dried with mannitol as a carrier to obtain dry powder particles with different particle size distribution for the preparation of curcumin dry powder inhaler. The solubility and physicochemical properties were further characterized by differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscopy. The characterization results showed that the product obtained in the experiment had reasonable particle size distribution and excellent solubility properties, which were positive for the treatment of COPD or other pulmonary diseases.

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Section: Introductionmentioning

confidence: 99%

A Novel Curcumin-Based Drug Powder Inhalation Medicine for Chronic Obstructive Pulmonary Disease

Shen

Jiang²,

Chen

et al. 2021

Bioinorganic Chemistry and Applications

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“…The reason is unclear, but unlikely due to osmotic stress, because of the facts that: (1) up to 0.4M NaCl or KCl fails to induce human CAMP gene in HT-29 cells, whereas different sugars do so readily ( Cederlund et al, 2013 ); (2) certain HDP genes such as AvBD14 are barely induced by any sugar even at 0.2M ( Figure 3 ); and (3) HDP genes such as CATHB1 are only induced by few, but not all, sugars ( Figures 2 , 3 ). Mannitol, a non-metabolizable and membrane-impermeable sugar alcohol ( Chen et al, 2020 ) induces chicken AvBD9 gene and also synergizes with butyrate in AvBD9 induction, similar to most other sugars, which is consistent with its ability to induce human CAMP gene ( Cederlund et al, 2013 ). Additionally, chickens produce maltase and sucrase to break down sucrose and maltose, respectively, but appear to lack lactase to break down and take up lactose ( Siddons, 1969 ; Siddons and Coates, 1972 ).…”

Section: Discussionmentioning

confidence: 56%

Synergistic Induction of Chicken Antimicrobial Host Defense Peptide Gene Expression by Butyrate and Sugars

et al. 2021

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Antimicrobial resistance is a major concern to public health demanding effective alternative strategies to disease control and prevention. Modulation of endogenous host defense peptide (HDP) synthesis has emerged as a promising antibiotic alternative approach. This study investigated a potential synergy between sugars and butyrate in inducing HDP gene expression in chickens. Our results revealed that sugars differentially regulated HDP expression in both gene- and sugar-specific manners in chicken HD11 macrophage cells. Among eight mono- and disaccharides tested, all were potent inducers of avian β-defensin 9 (AvBD9) gene (p<0.05), but only galactose, trehalose, and lactose obviously upregulated cathelicidin-B1 (CATHB1) gene expression. The expression of AvBD14 gene, on the other hand, was minimally influenced by sugars. Moreover, all sugars exhibited a strong synergy with butyrate in enhancing AvBD9 expression, while only galactose, trehalose, and lactose were synergistic with butyrate in CATHB1 induction. No synergy in AvBD14 induction was observed between sugars and butyrate. Although lactose augmented the expression of nearly all HDP genes, its synergy with butyrate was only seen with several, but not all, HDP genes. Mucin-2 gene was also synergistically induced by a combination of lactose and butyrate. Furthermore, lactose synergized with butyrate to induce AvBD9 expression in chicken jejunal explants (p<0.05). Mechanistically, hyper-acetylation of histones was observed in response to both butyrate and lactose, relative to individual compounds. Mitogen-activated protein kinase, NF-κB, and cyclic adenosine monophosphate signaling pathways were also found to be involved in butyrate- and lactose-mediated synergy in AvBD9 induction. Collectively, a combination of butyrate and a sugar with both HDP-inducing and barrier protective activities holds the promise to be developed as an alternative to antibiotics for disease control and prevention.

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“…Mannitol is a non-hygroscopic sugar alcohol derived from mannose and is naturally present in most species of brown seaweed [9]. It is a straight chain of six carbons with six hydroxyl groups with the chemical formula C6H14O6 [34,35]. The mannitol content in the fresh seaweed samples was significantly lower in June (7.1 ± 0.3% dry weight (dw)) when compared to the other two harvesting periods where similar results were obtained.…”

Section: Monosaccharide and Uronic Acid Compositionmentioning

confidence: 73%

Added Value of Ascophyllum nodosum Side Stream Utilization during Seaweed Meal Processing

et al. 2022

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Ascophyllum nodosum contains many valuable compounds, including polyphenols, peptides, and carotenoids that have been shown to exhibit biological activities. These compounds are not a priority ingredient in seaweed meal products for the current users. Hence, the aim of the study was to investigate the chemical and bioactive characteristics of A. nodosum as affected by seasonal variation and evaluate the potential benefits of alternative processing and the utilization of side streams for product development. The analysis of raw materials, press liquid, and press cake from alternative processing and the commercial seaweed meal at different harvesting periods indicated that the chemical composition is linked to the reproductive state of the algae. Phenolic content and ORAC activity increased following the seaweed’s fertile period, making alternative processing more promising in July and October compared to June. Several valuable ingredients were obtained in the press liquid, including polyphenols, which can be used in the development of new high-value bioactive products. The suggested alternative processing does not have a negative effect on the composition and quality of the current seaweed meal products. Hence, the extraction of valuable ingredients from the fresh biomass during the processing of seaweed meal could be a feasible option to increase the value and sustainability of seaweed processing.

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Mannitol: physiological functionalities, determination methods, biotechnological production, and applications

Cited by 61 publications

References 47 publications

A Novel Curcumin-Based Drug Powder Inhalation Medicine for Chronic Obstructive Pulmonary Disease

A Novel Curcumin-Based Drug Powder Inhalation Medicine for Chronic Obstructive Pulmonary Disease

Synergistic Induction of Chicken Antimicrobial Host Defense Peptide Gene Expression by Butyrate and Sugars

Added Value of Ascophyllum nodosum Side Stream Utilization during Seaweed Meal Processing

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