Mannose-targeted mesoporous silica nanoparticles for photodynamic therapy

Brevet, David; Gary‐Bobo, Magali; Raehm, Laurence; Richeter, Sébastien; Hocine, Ouahiba; Amro, Kassem; Loock, Bernard; Couleaud, Pierre; Frochot, Céline; Morére, Alain; Maillard, Philippe; Garcia, Marcel; Durand, Jean‐Olivier

doi:10.1039/b900427k

Cited by 235 publications

(165 citation statements)

References 25 publications

Supporting

Mentioning

160

Contrasting

Unclassified

Order By: Relevance

“…More importantly, the external surface of MSNs can be modified with tumor-recognition molecules to increase the active targetability through the receptor-mediated endocytosis. Several well-known targeting molecules, such as folate [21], mannose [22], hyaluronic acid [23], arginine-glycineaspartate (RGD) [24], and lactobionic acid [25] have been conjugated to MSNs successfully, resulting in significantly enhanced antitumor efficiency.…”

Section: Introductionmentioning

confidence: 99%

Lactosaminated mesoporous silica nanoparticles for asialoglycoprotein receptor targeted anticancer drug delivery

Quan¹,

Pan²,

Wang³

et al. 2016

Nano Online

View full text Add to dashboard Cite

Background: Mesoporous silica nanoparticles (MSNs) have several attractive properties as a drug delivery system, such as ordered porous structure, large surface area, controllable particle size as well as interior and exterior dual-functional surfaces. The purpose of this study was to develop novel lactosaminated mesoporous silica nanoparticles (Lac-MSNs) for asialoglycoprotein receptor (ASGPR) targeted anticancer drug delivery.

show abstract

Section: Introductionmentioning

confidence: 99%

Lactosaminated mesoporous silica nanoparticles for asialoglycoprotein receptor targeted anticancer drug delivery

Quan¹,

Pan²,

Wang³

et al. 2016

Nano Online

View full text Add to dashboard Cite

show abstract

“…The St ö ber procedure, which is known to generate amorphous SiNPs of a controlled size [121] , the reverse microemulsion (water-in-oil) method, and recently direct microemulsion (oil-in-water) procedure [122,123] , and the sol-gel method have all been applied to design nanoparticles for PDT applications. Both noncovalent encapsulation and covalent conjugation have been used as methods for the immobilization of the PS inside or on the surface of the SiNPs [122] . Noncovalent encapsulation is the most frequently described method, whereas covalent linkage of the PS appears to be more effi cient, as no release of the PS from the nanoparticles occurs.…”

Section: Silica-based Nanoparticlesmentioning

confidence: 99%

Can nanotechnology potentiate photodynamic therapy?

Huang¹,

Sharma

Dai³

et al. 2012

Nanotechnology Reviews

126

View full text Add to dashboard Cite

Photodynamic therapy (PDT) uses the combination of nontoxic dyes and harmless visible light to produce reactive oxygen species that can kill cancer cells and infectious microorganisms. Due to the tendency of most photosensitizers (PS) to be poorly soluble and to form nonphotoactive aggregates, drug-delivery vehicles have become of high importance. The nanotechnology revolution has provided many examples of nanoscale drug-delivery platforms that have been applied to PDT. These include liposomes, lipoplexes, nanoemulsions, micelles, polymer nanoparticles (degradable and nondegradable), and silica nanoparticles. In some cases (fullerenes and quantum dots), the actual nanoparticle itself is the PS. Targeting ligands such as antibodies and peptides can be used to increase specifi city. Gold and silver nanoparticles can provide plasmonic enhancement of PDT. Two-photon excitation or optical upconversion can be used instead of one-photon excitation to increase tissue penetration at longer wavelengths. Finally, after sections on in vivo studies and nanotoxicology, we attempt to answer the title question, " can nanotechnology potentiate PDT ? "

show abstract

mentioning

confidence: 99%

“…Due to the recognized biosafety and easy synthesis of materials, silica-based NPs occupy a prominent status in biomedical research. In recent years, mesoporous silica NPs have attracted increasing attention for optical imaging, magnetic resonance imaging, photodynamic therapy and targeted drug delivery [19][20][21][22][23][24].Liposomes are biologically derived vesicles composed of an aqueous core surrounded by a phospholipid bilayer [25]. These vesicles have been designed and utilized as vehicles for drugs, genetic material or imaging agents [26].…”

mentioning

confidence: 99%

A Flow Cytometry‐based Method for the Screening of Nanomaterial‐induced Reactive Oxygen Species Production in Leukocytes Subpopulations in Whole Blood

Kermanizadeh

Jantzen

Brown

et al. 2017

Basic Clin Pharma Tox

View full text Add to dashboard Cite

To date, the use and translation of nanomedicine from the laboratory to the clinic has been relatively slow. Among other issues, one of the reasons for this tardiness is the lack of the availability of quick and reliable toxicity tools for the screening of nanomaterials (NMs). In this investigation, we apply a flow cytometry-based method for the detection of nanomaterialinduced oxidative stress by measurement of reactive oxygen species production in specific leukocyte subpopulations in human whole blood. The screening of a panel of relevant nanomedical-associated materials (liposomes, silica, iron oxide and functionalized single-walled carbon nanotubes) demonstrated that only the carbon nanotubes induced oxidative stress in human circulating leukocytes. In summary, we apply and corroborate a flow cytometry-based method for the simple and effective measurement of NM-induced oxidative stress in human blood subpopulations after realistic and relevant exposure scenarios which is extremely useful in future toxicological applications.The rapid development of nanotechnology goes hand in hand with concerns about the potential adverse effects of nanomaterial (NM) exposure on human health and the environment. In addition, the apparent knowledge gaps in our understanding of the interaction between NMs and cells, their transformation and their eventual fate in different biological systems mean that hazard assessment is very challenging.Nanomedicine is defined as the application and utilization of nanotechnology to medicine and human health, in particular with regard to the diagnosis and treatment of disease. Over the last two decades, a wide range of NMs with varying size, shape, charge and other physicochemical characteristics are tailored to determine specific function, resulting in desirable optical, electronic, magnetic and biological attributes. The current nanomedicine applications mainly include vehicles for targeted drug delivery, NM platforms for biomedical imaging and therapeutic applications for treating clinical diseases [1,2]. Despite these promising medical applications, the safety concern for NMs is a key determinant factor in the assessment of their clinical potential. Therefore, it is imperative to implement risk reduction strategies for all materials proposed for medical applications. The same physicochemical characteristics that make NMs desirable for medical applications might contribute to their potential adverse effects -particle size and surface properties can largely influence the bioavailability, transport, biotransformation, cellular uptake and toxicity of the material in question [3,4].Iron oxide nanoparticles (NPs) can exhibit a unique form of superparamagnetism which is highly useful and desirable in biomedicine for several medical applications, principally relating to imaging and drug delivery to the central nervous system and various tumours [5,6]. This property is believed to be size-dependent and only occurs at around 10-20 nm [7]. Iron oxide is one of the few NMs with current clin...

show abstract

Mannose-targeted mesoporous silica nanoparticles for photodynamic therapy

Abstract: Functionalisation of MSN with mannose for PDT applications dramatically improved the efficiency of PDT on breast cancer cells.

Cited by 235 publications

References 25 publications

Lactosaminated mesoporous silica nanoparticles for asialoglycoprotein receptor targeted anticancer drug delivery

Lactosaminated mesoporous silica nanoparticles for asialoglycoprotein receptor targeted anticancer drug delivery

Can nanotechnology potentiate photodynamic therapy?

A Flow Cytometry‐based Method for the Screening of Nanomaterial‐induced Reactive Oxygen Species Production in Leukocytes Subpopulations in Whole Blood

Contact Info

Product

Resources

About