Maoberry (<i>Antidesma bunius</i>) Improves Glucose Metabolism, Triglyceride Levels, and Splenic Lesions in High-Fat Diet-Induced Hypercholesterolemic Rats

Udomkasemsab, Arunwan; Ngamlerst, Chattraya; Kwanbunjun, Karunee; Krasae, Thanyaluk; Amnuaysookkasem, Krieangsak; Chunthanom, Pornprapha; Prangthip, Pattaneeya

doi:10.1089/jmf.2018.4203

Cited by 12 publications

(15 citation statements)

References 22 publications

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“…The present study has demonstrated a significantly altered lipid profile of HFD fed rats than control ones causing dyslipidemia along with elevate NEFA and glucose levels. These changes were also found by Guo et al, 2018 , Udomkasemsab et al, 2019 , Xia et al, 2019 . The hallmarks of dyslipidemia in obesity are elevated TGs in combination with elevated levels of the majority of small dense LDL-C as well as low HDL-C that was observed in HFD group.…”

Section: Discussionsupporting

confidence: 55%

Anti-obesity potential of Moringa olifera seed extract and lycopene on high fat diet induced obesity in male Sprauge Dawely rats

Kilany

Abdelrazek

Aldayel

et al. 2020

Saudi Journal of Biological Sciences

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Present research explored the anti-obesity effect of Moringa olifera seed oil extract and lycopene (LYC). Forty eight male Sprauge Dawely rats were divided equally into 6 groups. Group Ι (C) served as control, group ΙΙ (MC) was given Moringa olifera seed oil extract (800 mg/kg b.wt) for 8 weeks, group ΙΙΙ (LC) was given (20 mg/kg b.wt) LYC for 8 weeks, group ΙV (O) received high fat diet (HFD) for 20 weeks, group Ѵ (MO), was given HFD for 20 weeks and received (800 mg/kg b.wt) Moringa olifera seed oil extract for last 8 weeks and group ѴΙ (LO), received HFD for 20 weeks and was given (20 mg/kg b.wt) LYC for last 8 weeks. Hematology, lipid peroxidation and antioxidants, non-esterified fatty acids (NEFA), glucose, lipid profile, serum liver and kidney biomarkers, inflammatory markers, leptin, resistin and heart fatty acid binding protein (HFABP) were determined. Also histopathology for liver, kidney and aorta were performed besides immunohistochemistry (IHC) for aortic inducible nitric oxide synthase (iNOS). Administration of Moringa olifera seed oil extract and LYC significantly ameliorated the HFD induced hematological and metabolic perturbations as well as reduced leptin and resistin. Both treatments exerted these effects through promotion of antioxidant enzymes and reducing lipid peroxidation as well as inflammatory cytokines along with reduced iNOS protein expression. Administration of Moringa olifera seed oil extract and LYC have anti-obesity potential in HFD induced obesity in male Sprauge Dawely rats.

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Section: Discussionsupporting

confidence: 55%

Anti-obesity potential of Moringa olifera seed extract and lycopene on high fat diet induced obesity in male Sprauge Dawely rats

Kilany

Abdelrazek

Aldayel

et al. 2020

Saudi Journal of Biological Sciences

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“…This is consistent with the study of berry fruits that reported the highest amount of cyanidin and peonidin among all anthocyanins [35]. Previously, we have reported that Maoberry extracts are sources of many essential nutrients and high in antioxidants [9]. Other bioactive compounds in Maoberry fruit ( Antidesma bunius (L.) Spreng have been reported such as ascorbic acid, gallic acid, (−)-epicatechin, (+)-catechin, and cyanidin-3-O-glucoside [13, 36].…”

Section: Discussionsupporting

confidence: 91%

“…The environmental conditions are controlled in order to reduce or get rid of animal distress. Our previous studies reported that Maoberry extract could benefit against hypercholesterolemia and cardiovascular disease risk factors by antioxidant and anti-inflammation properties [8, 9]. The current study further demonstrates the contributions of Maoberry extract on fat metabolism in liver tissue.…”

Section: Discussionsupporting

confidence: 76%

“…Previous reports suggest that fruits rich in flavonoids and phenolic acids have been shown to improve the features of NAFLD, such as oxidative stress, dyslipidemia, liver steatosis, and inflammation in rodents [10–12]. Our previous study reported the health benefits of Maoberry around four to sixteen portions a day could against in hypercholesterolemia and progression of cardiac tissue deterioration in rats [8, 9]. Supplement rats with Maoberry might be somehow useful on fat metabolism in liver tissues.…”

Section: Introductionmentioning

confidence: 97%

“…Simple steatosis can progress to nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and ultimately hepatocellular carcinoma [6]. Consumption of a high fat diet causes increasing body weight and enlargement of internal organs, including the liver, as well as dyslipidemia and obesity in rats [7–9]. Feeding high fat diet to rats were able to attribute characteristics hypercholesterolemia which is relevance to human biology [8–12].…”

Section: Introductionmentioning

confidence: 99%

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The potential of antioxidant-rich Maoberry (Antidesma bunius) extract on fat metabolism in liver tissues of rats fed a high-fat diet

Ngamlerst

Udomkasemsab

Kongkachuichai

et al. 2019

BMC Complement Altern Med

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BackgoundObesity and dyslipidemia are major risk factors associated with non-alcoholic fatty liver disease (NAFLD). NAFLD refers to the accumulation of fat in more than 5% of the liver without alcohol consumption. NAFLD is the most common liver disease and is rapidly becoming a global public health problem. Maoberry (Antidesma bunius) is a fruit rich in antioxidants, especially phenolic compounds, which are reported to have benefits for patients with NAFLD.MethodsWe evaluated the effect of Maoberry extract on fat metabolism in liver tissues of high fat diet–induced rats. Five (5) groups (n = 12) of male Sprague-Dawley (SD) rats were divided into those given a high fat diet with no treatment (HF), different dosages of Maoberry extracts (0.38 [ML], 0.76 [MM) and 1.52 [MH] g/kg body weight) and 10 mg/kg statin (STAT). The rats were fed a high fat diet for 4 weeks to induce obesity and subsequently continued more for 12 weeks with treatments of Maoberry extracts or STAT. The levels of triglyceride, liver enzymes, oxidative stress and inflammation markers, triglyceride synthesis regulators, and pathology of the liver in high fat diet-induced rats were investigated.ResultsFeeding Maoberry extract in MH groups resulted in decreasing levels of serum alanine aminotransferase (ALT), liver triglyceride, liver thiobarbituric acid reactive substances (TBARS) and mRNA expression of tumour necrosis factor (TNF)-α, interleukin (IL)-6, glycerol-3-phosphate acyltransferase (GPAT)-1 and acetyl-coenzyme A carboxylase (ACC) compared with the HF group (P < 0.05). Moreover, histopathological study of the liver showed reduced fat droplets in the Maoberry extract treatment groups, especially in MH groups and STAT treatment groups.ConclusionsThe improvements of fat metabolism in liver tissues of rats fed a high-fat diet were observed in Maoberry extracts treatment groups. The underline mechanism that link to fat metabolism might be through the process accompanied with down-regulated the gene expression of key enzymes of lipid production, antioxidant activity, and anti-inflammation properties of Maoberry extracts which contains high levels of phenolic and flavonoid compounds.

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Approaches for modifying cellular cholesterol levels and their application to mechanistic studies: Examples from the ion channel field

Rosenhouse‐Dantsker¹,

Slayden²,

Bukiya³

2022

Cholesterol

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Maoberry (Antidesma bunius) Improves Glucose Metabolism, Triglyceride Levels, and Splenic Lesions in High-Fat Diet-Induced Hypercholesterolemic Rats

Cited by 12 publications

References 22 publications

Anti-obesity potential of Moringa olifera seed extract and lycopene on high fat diet induced obesity in male Sprauge Dawely rats

Anti-obesity potential of Moringa olifera seed extract and lycopene on high fat diet induced obesity in male Sprauge Dawely rats

The potential of antioxidant-rich Maoberry (Antidesma bunius) extract on fat metabolism in liver tissues of rats fed a high-fat diet

Approaches for modifying cellular cholesterol levels and their application to mechanistic studies: Examples from the ion channel field

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