Mapping of the Phenol Sulfotransferase Gene (STP) to Human Chromosome 16p12.1-p11.2 and to Mouse Chromosome 7

Dooley, Thomas P.; Obermoeller, R. D.; Leiter, Ed; Chapman, Harold D.; Falany, Charles N.; Deng, Zuoming; Siciliano, Michael J.

doi:10.1006/geno.1993.1494

Cited by 60 publications

(14 citation statements)

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“…More recently, genetic linkage of the SULT1A locus and a predisposition to autism spectrum disorders (ASD) has been reported (Dooley et al, 1993;Kumar et al, 2008;Weiss et al, 2008). Furthermore, individuals with ASD have decreased expression of SULT1A isoforms in platelets and in the gastrointestinal tract (Waring et al, 1996;Waring and Klovrza, 2000;Whiteley and Shattock, 2002;Kern et al, 2004).…”

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confidence: 99%

Expression and Localization of Cytosolic Sulfotransferase (SULT) 1A1 and SULT1A3 in Normal Human Brain

Salman

Kadlubar²,

Falany³

2009

Drug Metab Dispos

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ABSTRACT:Cytosolic sulfotransferases (SULTs) are a family of Phase II drugmetabolizing enzymes that catalyze the transfer of a sulfonate group from 3-phosphoadenosine 5-phosphosulfate to endogenous and xenobiotic compounds. Several SULT isoform messages have been detected in the human brain; however, protein expression patterns have not been characterized. Immunoblot analysis of the SULT1A1 and 1A3 isoforms was carried out with cytosolic fractions isolated from superior temporal gyrus, hippocampus, cerebellum, occipital pole, frontal pole, and temporal pole regions of normal adult human brains. SULT1A1 expression was highest in cytosolic fractions isolated from cerebellum, occipital, and frontal lobes, whereas, SULT1A3 expression was highest in cytosol from superior temporal gyrus, hippocampus, and temporal lobe. SULT1A1 and SULT1A3 immunoreactivities were found in both neurons and glial cells by immunohistochemical analysis in all brain regions studied. SULT1A1 is known to catalyze the metabolism of small phenols, whereas SULT1A3 sulfates catecholamine neurotransmitters. Because SULT1A1 and 1A3 have distinct substrate specificities, the differences in expression pattern and cellular localization of the SULT1A isoforms are probably associated with the distribution and function of their selective substrates in the different brain regions.

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confidence: 99%

Expression and Localization of Cytosolic Sulfotransferase (SULT) 1A1 and SULT1A3 in Normal Human Brain

Salman

Kadlubar²,

Falany³

2009

Drug Metab Dispos

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“…Recently, human phenol ST genes, SULT1A1 (alias STP1), SULT1A2 (alias STP2) and SULT1A3 (alias STM) were assigned to the same region on chromosome 16p12.1→ p11.2 , whereas the mouse phenol ST gene, Stp1 was mapped to mouse chromosome 7 (Dooley et al, 1993). These phenol ST genes appear to be orthologous in the three species .…”

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confidence: 99%

Chromosome assignments of rat phenol sulfotransferase ST1A1 and ST1C1 genes (<i>Sult1a1</i> and <i>Sult1c1</i>) by fluorescence in situ hybridization

Nagai¹,

Satoh

Usui³

et al. 1999

Cytogenet Genome Res

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“…and the thermolabile, or monoamine-pre ferring ("M") form (gene symbols STP and STM. respectively) have been mapped to human chromosome 16 (Dooley et al, 1993;Aksoy et al. 1994a).…”

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confidence: 99%

Dehydroepiandrosterone sulfotransferase gene (STD): localization to human chromosome band 19q13.3

Otterness

Mohrenweiser

Brandriff

et al. 1995

Cytogenet Genome Res

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Mapping of the Phenol Sulfotransferase Gene (STP) to Human Chromosome 16p12.1-p11.2 and to Mouse Chromosome 7

Cited by 60 publications

References 0 publications

Expression and Localization of Cytosolic Sulfotransferase (SULT) 1A1 and SULT1A3 in Normal Human Brain

Expression and Localization of Cytosolic Sulfotransferase (SULT) 1A1 and SULT1A3 in Normal Human Brain

Chromosome assignments of rat phenol sulfotransferase ST1A1 and ST1C1 genes (<i>Sult1a1</i> and <i>Sult1c1</i>) by fluorescence in situ hybridization

Dehydroepiandrosterone sulfotransferase gene (STD): localization to human chromosome band 19q13.3

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