Mapping the potential of thiolated pluronic based nanomicelles for the safe and targeted delivery of vancomycin against staphylococcal blepharitis

Jahan, Faryal; Zaman, Shahiq uz; Arshad, Rabia; Tabish, Tanveer A.; Naseem, Abbas Ali; Shahnaz, Gul

doi:10.1016/j.jddst.2020.102220

Cited by 16 publications

(17 citation statements)

References 32 publications

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“…The characteristic peaks of HA 35 were observed in PU2‐nHA and PU2‐nHA‐VA at 2θ = 32°, and 33°, accompanied by some lower intensity peaks located at 2θ = 26°, 46.5°, and 49°, and others that corroborate the presence of HA are located at 2θ = 34° and 39.5°. VA characteristic peaks vanished in the composites showing that the drug lost its crystallinity during formulation development and remained in an amorphous form inside the membranes as can be seen in other VA‐polymer formulations 36 …”

Section: Resultsmentioning

confidence: 65%

Polyurethane electrospun membranes with hydroxyapatite‐vancomycin for potential application in bone tissue engineering and drug delivery

Vásquez-López

Castillo‐Ortega

Chan-Chan

et al. 2021

J of Applied Polymer Sci

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The purpose of this study is to evaluate the drug delivery behavior and other properties of electrospun composite membranes for potential use in tissue engineering. Tecoflex® (PU1), and a lab‐made polyurethane (PU2) were studied. They were mixed with nano‐hydroxyapatite (PU1‐nHA and PU2‐nHA) and vancomycin (PU1‐VA and PU2‐VA) or mixed with both, nHA and VA (PU1‐nHA‐VA and PU2‐nHA‐VA). Scanning electron microscopy showed a porous structure in all the electrospun membranes with smooth fibers in PU1 and its composites with sizes in the range of 0.6–0.9 μm and nanoparticles of HA, both, adhered and embedded on the PU fibers were observed. nHA and VA affected the thermal and mechanical behavior of composites. Elastic modulus, cytotoxicity, and kinetic release were affected by the PU and nHA. Cell viability up to 75% showed that all membrane extracts are not cytotoxic while microbial inhibition activity was observed in PU1‐VA, PU1‐nHA‐VA, and PU2‐VA.

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Section: Resultsmentioning

confidence: 65%

Polyurethane electrospun membranes with hydroxyapatite‐vancomycin for potential application in bone tissue engineering and drug delivery

Vásquez-López

Castillo‐Ortega

Chan-Chan

et al. 2021

J of Applied Polymer Sci

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“…HA-CIP-SNEDDS showed cell viability of 96% at increased drug concentrations as compared to the CIP SNEDDS showing a 65% statistical significance ( p < 0.05). Therefore, the safety profile of the HA-CIP SNEDDS is owed to the addition of biocompatible, biodegradable, and entero-protective HA [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection

et al. 2021

Self Cite

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Ciprofloxacin (CIP), a potent anti-bacterial agent of the fluroquinolone family, shows poor solubility and permeability, thus leading to the development of intracellular pathogens induced multi-drug resistance and biofilms formation. To synergistically improve the biopharmaceutical parameters of CIP, a hyaluronic acid (FDA approved biocompatible polymer) functionalized self-nano emulsifying drug delivery system (HA-CIP-SNEDDS) was designed in the present study. SNEDDS formulations were tested via solubility, droplet size, zeta potential, a polydispersity index, thermodynamic stability, surface morphology, solid-state characterization, drug loading/release, cellular uptake, and biocompatibility. The final (HA-CIP-SNEDDS) formulation exhibited a mean droplet size of 50 nm with the 0.3 poly dispersity index and negative zeta potential (−11.4 mV). HA-based SNEDDS containing CIP showed an improved ability to permeate goat intestinal mucus. After 4 h, CIP-SNEDDS showed a 2-fold and HA-CIP-SNEDDS showed a 4-fold permeation enhancement as compared to the free CIP. Moreover, 80% drug release of HA-CIP-SNEDDS was demonstrated to be superior and sustained for 72 h in comparison to free CIP. However, anti-biofilm activity of HA-CIP-SNEDDS against Salmonella typhi was higher than CIP-SNEDDS and free CIP. HA-CIP-SNEDDS exhibited increased biocompatibility and improved oral pharmacokinetics as compared to free CIP. Taken together, HA-CIP-SNEDDS formulation seems to be a promising agent against Salmonella typhi with a strong targeting potential.

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“…The thermal behavior of pure gum sample (PM) and modified gum (TRM) was studied by using a differential scanning calorimetry. Sample (1.01 mg) was crimped in a standard pan and heated in a temperature range of 30–450 °C at a heating rate 15 K per minute in a nitrogen atmosphere in differential scanning calorimeter (Perkin Elemer) [ 29 ].…”

Section: Methodsmentioning

confidence: 99%

Improved Mucoadhesion, Permeation and In Vitro Anticancer Potential of Synthesized Thiolated Acacia and Karaya Gum Combination: A Systematic Study

Munot

Kandekar²,

Rikame³

et al. 2022

Molecules

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Thiolation of polymers is one of the most appropriate approaches to impart higher mechanical strength and mucoadhesion. Thiol modification of gum karaya and gum acacia was carried out by esterification with 80% thioglycolic acid. FTIR, DSC and XRD confirmed the completion of thiolation reaction. Anticancer potential of developed thiomer was studied on cervical cancer cell lines (HeLa) and more than 60% of human cervical cell lines (HeLa) were inhibited at concentration of 5 µg/100 µL. Immobilized thiol groups were found to be 0.8511 mmol/g as determined by Ellman’s method. Cytotoxicity studies on L929 fibroblast cell lines indicated thiomers were biocompatible. Bilayered tablets were prepared using Ivabradine hydrochloride as the model drug and synthesized thiolated gums as mucoadhesive polymer. Tablets prepared using thiolated polymers in combination showed more swelling, mucoadhesion and residence time as compared to unmodified gums. Thiol modification controlled the release of the drug for 24 h and enhanced permeation of the drug up to 3 fold through porcine buccal mucosa as compared to tablets with unmodified gums. Thiolated polymer showed increased mucoadhesion and permeation, anticancer potential, controlled release and thus can be utilized as a novel excipient in formulation development.

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Mapping the potential of thiolated pluronic based nanomicelles for the safe and targeted delivery of vancomycin against staphylococcal blepharitis

Cited by 16 publications

References 32 publications

Polyurethane electrospun membranes with hydroxyapatite‐vancomycin for potential application in bone tissue engineering and drug delivery

Polyurethane electrospun membranes with hydroxyapatite‐vancomycin for potential application in bone tissue engineering and drug delivery

A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection

Improved Mucoadhesion, Permeation and In Vitro Anticancer Potential of Synthesized Thiolated Acacia and Karaya Gum Combination: A Systematic Study

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