Mapping the Surface Characteristics of Polystyrene Microtiter Wells by a Multimode Scanning Force Microscopy Approach

Allen, Stephanie; Connell, Simon D.; Chen, X.; Davies, John A.; Davies, Martyn C.; Dawkes, Adrian; Roberts, Clive J.; Tendler, Saul J. B.; Williams, Philip M.

doi:10.1006/jcis.2001.7800

Cited by 7 publications

(5 citation statements)

References 49 publications

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“…Local variations in adhesion may also allow identification of surface contaminants [1176][1177][1178][1179], the study of the influence of surface topography [625,701,1180] and roughness [1179] on adhesion, or the monitoring of surface heterogeneity during production steps of PEO layer grafted to a glass surface [1181].…”

Section: Force Volume Modementioning

confidence: 99%

Force measurements with the atomic force microscope: Technique, interpretation and applications

Butt

Cappella

Kappl

2005

Surface Science Reports

3,242

2,949

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Section: Force Volume Modementioning

confidence: 99%

Force measurements with the atomic force microscope: Technique, interpretation and applications

Butt

Cappella

Kappl

2005

Surface Science Reports

3,242

2,949

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Section: Introductionmentioning

confidence: 99%

“…In this paper we have attempted to investigate important fluid properties such as contact angle and interfacial tension on a submicrometer scale using the AFM. Nanometer-sized liquid droplets of a volatile hydrocarbon oil (predominantly C17−C18 hydrocarbons) had previously been found on the surface of manufactured polystyrene components, , and this characterized system was used to develop the technique and test its applicability. No effort was made to alter the physical properties of the oil to facilitate investigation by AFM, and all measurements were made in ambient or aqueous buffer conditions.…”

Section: Introductionmentioning

confidence: 99%

Investigating the Interfacial Properties of Single-Liquid Nanodroplets by Atomic Force Microscopy

et al. 2002

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The interaction of a liquid with a surface is of fundamental importance to many areas of scientific research. Information on the properties of liquids at surfaces at the microscopic scale is also required to elucidate the mechanisms behind macroscopic observations. In this study, the atomic force microscope (AFM) was employed in various complementary modes of operation to investigate the properties of nanometerscale oil droplets existing on a polystyrene surface. Force curve mapping was used to gently probe the surface of the fluid droplets, and through automated analysis of the force curves the true topography and microscopic contact angle of the droplets were extracted. The contact angle was found to be 13 ( 2°, which is in excellent agreement with values obtained from macroscopic measurements. A discrepancy between these values and contact angle values obtained from tapping mode images were attributed to deformation of the soft interface. The resultant phase contrast mechanisms in the liquid tapping mode images are discussed and are attributed to energy dissipated in the deformable oil-water interface. The interfacial tension of this oil-water junction was then measured using the AFM and again found to be in close agreement with theory and macroscopic measurement. Finally, using the above information, the force exerted on the sample by a scanning tapping tip in fluid was derived and compared with forces experienced during tapping mode imaging in air. The presented data thus demonstrate the complementary nature of the employed imaging modes for the investigation of liquid interfaces and illustrate the benefits of a combined surface analytical approach for their characterization. We also highlight the ability of AFM to both measure interfacial properties and investigate the topography of the underlying substrate at the nanometer scale, indicating its potential to improve the understanding of the effect of surface topography on such properties.

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“…The domes appeared darker than flat surface, indicating that the dome is more energy dissipative than the flat surface 39. It can be postulated that the domes consisted of disordered solids which thereby exhibited higher energy dissipation than their flat crystalline counterparts 45…”

Section: Resultsmentioning

confidence: 99%

Water Sorption Induced Transformations in Crystalline Solid Surfaces: Characterization by Atomic Force Microscopy

Chen

Haugstad

et al. 2010

Journal of Pharmaceutical Sciences

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Mapping the Surface Characteristics of Polystyrene Microtiter Wells by a Multimode Scanning Force Microscopy Approach

Cited by 7 publications

References 49 publications

Force measurements with the atomic force microscope: Technique, interpretation and applications

Force measurements with the atomic force microscope: Technique, interpretation and applications

Investigating the Interfacial Properties of Single-Liquid Nanodroplets by Atomic Force Microscopy

Water Sorption Induced Transformations in Crystalline Solid Surfaces: Characterization by Atomic Force Microscopy

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