Marchantin C: A potential anti-invasion agent in glioma cells

Shen, Jie; Li, Gang; Liu, Qinglin; He, Qiaowei; Gu, Jinhai; Shi, Yufeng; Lou, Hongxiang

doi:10.4161/cbt.9.1.10279

Cited by 32 publications

(19 citation statements)

References 21 publications

(31 reference statements)

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“…Bryophyte flavonoids are of great significance in research on phylogeny and metabolism [13–14]. Extracts from bryophytes which contain flavonoids have been investigated extensively for their potential pharmacological applications: cytotoxic, anticancer and antitumor [15–17], antifungal [18–19], antibacterial [20–21] and antioxidant activities, and their ability to inhibit AChE activity [22]. …”

Section: Introductionmentioning

confidence: 99%

Total flavonoid concentrations of bryophytes from Tianmu Mountain, Zhejiang Province (China): Phylogeny and ecological factors

et al. 2017

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The flavonoids in bryophytes may have great significance in phylogeny and metabolism research. However, to date there has been little research on bryophyte metabolites, especially flavonoids. To redress this somewhat, we determined flavonoid concentrations of bryophytes from Tianmu Mountain through a colorimetric assay and considered the factors influencing the results. This is the first time that the flavonoid contents of bryophytes have been examined in detail. The results revealed a range of total flavonoid concentrations in 90 samples collected from Tianmu Mountain from 1.8 to 22.3 mg/g (w/w). The total flavonoid contents of liverworts were generally higher than those of mosses; acrocarpous mosses had generally higher values than that of pleurocarpous mosses. The total flavonoid contents of bryophytes growing at lower light levels were general higher than those growing in full-sun. The total flavonoid contents of epiphytic bryophytes were highest, while those of aquatic bryophytes were the lowest. Total flavonoid contents of species growing at low-latitudes were much higher than those at high-latitude individuals. In conclusion, total flavonoid contents of bryophytes have some connection with plant phylogeny; more flavonoids might be contained in relatively primitive bryophytes. Meanwhile, the effects of ecological factors on total flavonoid contents of bryophytes exist; light and habitat (especially tree habitat and river habitat) might be representative factor.

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Section: Introductionmentioning

confidence: 99%

Total flavonoid concentrations of bryophytes from Tianmu Mountain, Zhejiang Province (China): Phylogeny and ecological factors

et al. 2017

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“…1), which was extracted from Asterella angusta, was found to inhibit the proliferation of human glioblastoma A172 cells. Further examination showed that marchantin C suppressed the migration and invasion of cancer cells through the inhibition of MMPs and Erk/MAPK signaling in human glioma T98G and U87 cells [5,6]. Another homolog of bisbibenzyl plagiochin E isolated from Marchantia polymorpha, was found to have the ability to reverse multidrug resistance (MDR) in K562/A02 cells [7].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of riccardin D on growth of human non-small cell lung cancer: In vitro and in vivo studies

Xue

Sun

et al. 2012

Lung Cancer

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“…The median life expectancy for glioma patients is approximately 14 months. A maximum of 5% of patients are alive 5 years after diagnosis despite multiple advanced treatments [Shen et al, ]. The morbidity of glioma is primarily due to its rapid growth, angiogenesis, and invasion throughout the brain [Furnari et al, ].…”

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confidence: 99%

Let‐7f Inhibits Glioma Cell Proliferation, Migration, and Invasion by Targeting Periostin

Yan

Han

Xue

et al. 2015

J of Cellular Biochemistry

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Glioma is one of the most aggressive and malignant tumor types. Despite advances in surgery, imaging, chemotherapy, and radiation, glioma patient prognosis remains poor. Glioma pathogenesis is an urgent problem that must be solved. MicroRNAs (miRNAs) are endogenous small non-coding RNAs that are key post-transcriptional regulators of gene expression. miRNA deregulation commonly occurs in human tumorigenesis. In the present study, the expression levels of Let-7f were down-regulated in both glioma tissues and glioma cells. The enhanced expression of Let-7f suppressed glioma cells proliferation, migration, and invasion via direct targeting perisotin oncogenic activity. Experiments with periostin siRNA or over-expression further suggest that Let-7f may serve as tumor suppressors through perisotin signal. These findings provide insights regarding the role and mechanism of Let-7f in regulating biological behavior of glioma cells via the Let-7f/periostin axis, and Let-7f may serve as a potential therapeutic target in glioma.

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Marchantin C: A potential anti-invasion agent in glioma cells

Cited by 32 publications

References 21 publications

Total flavonoid concentrations of bryophytes from Tianmu Mountain, Zhejiang Province (China): Phylogeny and ecological factors

Total flavonoid concentrations of bryophytes from Tianmu Mountain, Zhejiang Province (China): Phylogeny and ecological factors

Inhibitory effect of riccardin D on growth of human non-small cell lung cancer: In vitro and in vivo studies

Let‐7f Inhibits Glioma Cell Proliferation, Migration, and Invasion by Targeting Periostin

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