Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression

Saito‐Sasaki, Natsuko; Sawada, Yu; Mashima, Emi; Yamaguchi, Takashi; Ohmori, Shun; Yoshioka, Haruna; Haruyama, Sanehito; Okada, Etsuko; Nakamura, Motonobu

doi:10.1038/s41598-018-23623-9

Cited by 41 publications

(37 citation statements)

References 27 publications

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“…For example, resolvin E1 and resolvin E3 alleviated allergic airway inflammation by inhibiting the production of IL-17A ( 19 , 20 ). Maresin 1 reduced IL-17A production by γδ TCRmid + and CD4 + T cells in imiquimod-induced skin inflammation ( 47 ). Thus, our findings indicated that IL-17A might get involved in the alternative function of MCTR1 on LPS-induced cardiac injury.…”

Section: Discussionmentioning

confidence: 99%

γδ T/Interleukin-17A Contributes to the Effect of Maresin Conjugates in Tissue Regeneration 1 on Lipopolysaccharide-Induced Cardiac Injury

Yang¹,

Li²,

Li³

et al. 2021

Front. Immunol.

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The mechanisms underlying sepsis-induced cardiomyopathy (SIC) remain poorly understood, and there are no specific therapeutics for SIC. We investigated the effects of maresin conjugates in tissue regeneration 1 (MCTR1) on SIC and explored its potential mechanisms. The experiments were conducted using an endotoxemia model induced by lipopolysaccharide (LPS). Mice were given MCTR1 intravenously 6 h after LPS stimulation. Echocardiography was performed to assess cardiac function 12 h after LPS administration. Treatment with MCTR1 significantly enhanced cardiac function and reduced LPS-induced increase of mRNA expression levels of inflammation cytokines. Transcriptomic analysis indicated that MCTR1 inhibited neutrophil chemotaxis via the IL-17 signaling pathway. We confirmed that MCTR1 reduced the expressions of neutrophil chemoattractants and neutrophil infiltration in the LPS-stimulated hearts. MCTR1 also resulted in a considerable reduction in IL-17A production mainly derived from γδ T cells. Moreover, our results provided the first evidence that neutralizing IL-17A or depletion of γδ T cells markedly decreased neutrophil recruitment and enhanced cardiac function in LPS-induced cardiac injury. These results suggest that MCTR1 alleviates neutrophil infiltration thereby improves cardiac function in LPS-induced cardiac injury via the IL-17 signaling pathway. Thus, MCTR1 represented a novel therapeutic strategy for patients with SIC.

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Section: Discussionmentioning

confidence: 99%

γδ T/Interleukin-17A Contributes to the Effect of Maresin Conjugates in Tissue Regeneration 1 on Lipopolysaccharide-Induced Cardiac Injury

Yang¹,

Li²,

Li³

et al. 2021

Front. Immunol.

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“…The impact of bioactive substances present in HRO on pro-inflammatory and anti-inflammatory mediators implicated in psoriasis, has been previously studied (16)(17)(18)(19). Although the mechanism of action of HRO in psoriasis is unknown, lipid mediators derived from DHA have demonstrated anti-inflammatory effects in animal disease models, including suppression of IL-17A (20).…”

Section: Discussionmentioning

confidence: 99%

A Randomized, Double-blind, Placebo-controlled Clinical Study to Investigate the efficacy of Herring Roe Oil for treatment of Psoriasis

Tveit

Brokstad²,

Berge³

et al. 2020

Acta Derm Venereol

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The effect of herring roe oil capsules was tested in patients with psoriasis. This study demonstrates a positive effect on psoriasis. Disease severity is important when determining the appropriate treatment of psoriasis patients. In recent years, several new drugs have become available for the treatment of severe psoriasis whereas there have been few treatment advances for patients with milder psoriasis. This study demonstrates promise for herring roe oil as a safe treatment option in patients with non-severe psoriasis.The effect of omega-3 polyunsaturated fatty acid supplements in patients with psoriasis vulgaris has previously been investigated, but interventions varied in source, composition, dose, administration route and duration of treatment. The observed beneficial effects in patients with psoriasis vulgaris using herring roe oil as a dietary supplement prompted this investigation. This randomised, double-blind and placebo-controlled study was designed and performed to explore the efficacy and safety of herring roe oil supplementation in 64 patients with plaque psoriasis (ClinicalTrials.gov: NCT03359577). The primary end-point was comparing the change in mean Psoriasis Area Severity Index (PASI) scores in the herring roe oil treatment group and the placebo group from baseline to week 26. In the intention-to-treat population, a statistically significant improvement in the mean PASI score was observed with herring roe oil compared to placebo at 26 weeks. In the recruited patient group, the measured improvement was greatest in patients with a PASI score from 5.5-9.9 at baseline.

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“…EPA suppresses the production of TNF-α and IL-1β, and inflammatory lipid mediators, such as PGE2 and LTB4 [ 57 ]. Patients with psoriasis exhibit a lower intake of ω-3 fatty acids compared with healthy controls [ 10 ], and the metabolites of ω-3 fatty acids, resolvin E1, resolvin D1, and Maresin 1, exert anti-inflammatory actions in imiquimod-induced psoriasis-like skin inflammation in mice [ 58 , 59 , 60 ]. Impaired skin inflammation was also observed in approximately 80% of patients with psoriasis using fish oil supplements [ 61 ].…”

Section: Daily Lifestyle and Inflammatory Skin Diseasesmentioning

confidence: 99%

Daily Lifestyle and Inflammatory Skin Diseases

Sawada

Saito‐Sasaki

Mashima

et al. 2021

IJMS

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Throughout life, it is necessary to adapt to the Earth’s environment in order to survive. A typical example of this is that the daily Earth cycle is different from the circadian rhythm in human beings; however, the ability to adapt to the Earth cycle has contributed to the development of human evolution. In addition, humans can consume and digest Earth-derived foods and use luxury materials for nutrition and enrichment of their lives, as an adaptation to the Earth’s environment. Recent studies have shown that daily lifestyles are closely related to human health; however, less attention has been paid to the fact that obesity due to excessive energy intake, smoking, and alcohol consumption contributes to the development of inflammatory skin diseases. Gluten or wheat protein, smoking and alcohol, sleep disturbance, and obesity drive the helper T (Th)1/Th2/Th17 immune response, whereas dietary fiber and omega-3 fatty acids negatively regulate inflammatory cytokine production. In this review, we have focused on daily lifestyles and the mechanisms involved in the pathogenesis of inflammatory skin diseases.

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Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression

Cited by 41 publications

References 27 publications

γδ T/Interleukin-17A Contributes to the Effect of Maresin Conjugates in Tissue Regeneration 1 on Lipopolysaccharide-Induced Cardiac Injury

γδ T/Interleukin-17A Contributes to the Effect of Maresin Conjugates in Tissue Regeneration 1 on Lipopolysaccharide-Induced Cardiac Injury

A Randomized, Double-blind, Placebo-controlled Clinical Study to Investigate the efficacy of Herring Roe Oil for treatment of Psoriasis

Daily Lifestyle and Inflammatory Skin Diseases

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